Eye movements in Autism: a window into the disorder? Impaired function in the sodium channel gene SCN2A is a major risk factor for autism spectrum disorder.

Wang and colleagues show that heterozygous loss of SCN2A in the cerebellum alters reflexive eye movements in both mouse and man and that a translatable gene therapy rescues such movements in mouse.

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD. Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ.

Article published in NeuronAccess to the manuscript