Group leader: Cyrille Vaillend

Cognition, Plasticity & Neuropathologies

In brief

Our team investigates the molecular and cellular mechanisms responsible for cognitive dysfunction in neurodevelopmental (Intellectual Disability, Coffin-Lowry Syndrome, Duchenne muscular dystrophy) and neurodegenerative diseases (Alzheimer). Our multidisciplinary approach in rodent models is complemented by preclinical explorations of treatments induced by environmental modifications, pharmacological and gene therapies.

Our research is based on an integrative, multi-scale and translational approach aimed at
(1) refining our understanding of the molecular and cellular mechanisms underlying brain plasticity and cognitive processes,
(2) identifying the multiple determinants and risk factors (genetic, developmental, metabolic) that contribute to their deterioration and drive neuronal network dysfunction in animal models of neurodevelopmental (Intellectual Disability, Coffin-Lowry Syndrome, Duchenne muscular dystrophy) and neurodegenerative diseases (Alzheimer’s disease) and
(3) exploring the potential of genetic, pharmacological and behavioral rescue strategies holding realistic prospects for therapeutic perspectives. This research program capitalizes on our expertise in plasticity and cognition mechanisms to dissect the brain functional organization and neuronal mechanisms underlying high-level functions (cognition, emotion, executive functions) that go awry in these pathologies. Our multidisciplinary approach is based on classical and new rodent models and encompass behavioral studies (motor, emotional, cognitive, social and executive functions), characterization of brain plasticity (synaptic and structural plasticity, adult neurogenesis) and of multiple determinants contributing to these diseases, such as the neurogenetic, developmental, non-neuronal (glial, vascular) and metabolic factors, complemented with in vivo brain imaging, biochemistry and cell signaling, confocal imaging, molecular biology, neurosurgery, gene therapy, pharmacology… Our projects are in framed within a highly collaborative international context that includes interactions with clinicians.

Selected publications

  • Belmaati-Cherkaoui M, Vacca O, Izabelle C, Boulay AC, Boulogne C, Gillet C, Barnier JV, Rendon A, Cohen-Salmon M and Vaillend C. Dp71 contribution to the molecular scaffold anchoring aquaporine-4 channels in brain macroglial cells. Glia. 2020 Nov 28. DOI: 10.1002/glia.23941
  • Castillon C, Gonzalez L, Dominichini F, Guyon S, Da Silva K, Durand C, Lestaevel P, Vaillend C, Laroche S, Barnier JV, Poirier R. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. Human Molecular Genetics. 2020 Jan 16. pii: ddz296. DOI: 10.1093/hmg/ddz296
  • Su M, Naderi K, Samson N, Youssef I, Fülöp L, Bozso Z, Laroche S, Delatour B, Davis S. Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology. Mol Neurobiol. 2019 Jan 25. DOI: 10.1007/s12035-019-1475-8
  • Chaalal A, Poirier R, Blum D, Laroche S, Enderlin V (2019) Thyroid hormone supplementation restores spatial memory, hippocampal markers of neuroinflammation, plasticity-related signalling molecules and b-amyloid peptide load in hypothyroid rats. Mol Neurobiol, 56(1):722-735. DOI: 10.1007/s12035-018-1111-z
  • Vaillend C, Chaussenot R. (2017) Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. Hum Mol Genet, 26(6):1041-1055. DOI: 10.1093/hmg/ddx013
  • Goyenvalle A, Griffith G, Babbs A, El Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. (2015) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med. 21(3):270-5. DOI: 10.1038/nm.3765


• Serrano C, Dos Santos M, Kereselidze D, Beugnies L, Lestaevel P, Poirier R, Durand C. Targeted Dorsal Dentate Gyrus or Whole Brain Irradiation in Juvenile Mice Differently Affects Spatial Memory and Adult Hippocampal Neurogenesis. Biology (Basel). 2021 Mar 4;10(3):192. doi: 10.3390/biology10030192.

• Joly F, Jeckel P, Kriebel M, Raut S, El Massioui N, Vaillend C, Johnson LR, Volkmer H, Doyère V. Disruption of Amygdala Tsc2 in Adolescence Leads to Changed Prelimbic Cellular Activity and Generalized Fear Responses at Adulthood in Rats. Cereb Cortex. 2022 Feb 12:bhab506. doi: 10.1093/cercor/bhab506.

• Relizani K, Echevarría L, Zarrouki F, Gastaldi C, Dambrune C, Aupy P, Haeberli A, Komisarski M, Tensorer T, Larcher T, Svinartchouk F, Vaillend C, Garcia L, Goyenvalle A. Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides. Nucleic Acids Res. 2022 Jan 11;50(1):17-34.doi: 10.1093/nar/gkab1199.


• Saoudi A, Zarrouki F, Sebrié C, Izabelle C, Goyenvalle A, Vaillend C. Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy. Dis Model Mech. 2021 Sep 1;14(9):dmm049028. doi: 10.1242/dmm.049028.

• Magne N, Rousseau V, Duarte K, Poëa-Guyon S, Gleize V, Mutel A, Schmitt C, Castel H, Idbaih A, Huillard E, Sanson M, Barnier JV. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. Cell Oncol (Dordr). 2021 Sep 22. doi: 10.1007/s13402-021-00635-8.

• Morice E, Enderlin V, Gautron S, Laroche S. Contrasting Functions of Mitogen- and Stress-activated Protein Kinases 1 and 2 in Recognition Memory and In Vivo Hippocampal Synaptic Transmission. Neuroscience. 2021 May 21;463:70-85. doi: 10.1016/j.neuroscience.2021.03.004

• Baudouin L, Adès N, Kanté K, Czarnecki A, Bachelin C, Baskaran A, Langui D, Millécamps A, Gurchenkov B, Velut Y, Duarte K, Barnier JV, Nait Oumesmar B, Bouslama-Oueghlani L. Co-culture of exogenous oligodendrocytes with unmyelinated cerebella: Revisiting ex vivo models and new tools to study myelination. Glia. 2021 Aug;69(8):1916-1931. doi: 10.1002/glia.24001

• Barboni MTS, Liber AMP, Joachimsthaler A, Saoudi A, Goyenvalle A, Rendon A, Roger JE, Ventura DF, Kremers J, Vaillend C. Altered visual processing in the mdx52 mouse model of Duchenne muscular dystrophy. Neurobiol Dis. 2021 May;152:105288. doi: 10.1016/j.nbd.2021.105288

• Belmaati Cherkaoui M, Vacca O, Izabelle C, Boulay AC, Boulogne C, Gillet C, Barnier JV, Rendon A, Cohen-Salmon M, Vaillend C. Dp71 contribution to the molecular scaffold anchoring aquaporine-4 channels in brain macroglial cells. Glia. 2021 Apr;69(4):954-970. doi: 10.1002/glia.23941


• Belmaati-Cherkaoui M, Vacca O, Izabelle C, Boulay AC, Boulogne C, Gillet C, Barnier JV, Rendon A, Cohen-Salmon M and Vaillend C. Dp71 contribution to the molecular scaffold anchoring aquaporine-4 channels in brain macroglial cells. Glia. 2020 Nov 28. doi: 10.1002/glia.23941
• Hendriksen JGM, Thangarajh M, Kan HE, Muntoni F; ENMC 249th workshop study group. 249th ENMC International Workshop: The role of brain dystrophin in muscular dystrophy: Implications for clinical care and translational research, Hoofddorp, The Netherlands, November 29th-December 1st 2019 [published online ahead of print, 2020 Aug 15]. Neuromuscul Disord. 2020;S0960-8966(20)30554-X. doi: 10.1016/j.nmd.2020.08.357
• Briatore F, Pregno G, Di Angelantonio S, Frola E, De Stefano EM, Vaillend C, Sassoè-Pognetto M, Patrizi A. Dystroglycan mediates clustering of essential GABAergic components in cerebellar Purkinje cells. Frontiers in Molecular Neuroscience. 2020. Vol 13, Article 164. doi: 10.3389/fnmol.2020.00164.
• Brignol TN, Mornet D, Montañez C, Ventura DF, Vaillend C, Rendón A. What is the ocular phenotype associated with a single exon 78 deletion in Duchenne muscular dystrophy? Letter to the editor. Journal of Human Genetics. 2020. 10.1038/s10038-020-0755-5.
• Aupy P, Zarrouki F, Sandro Q, Gastaldi C, Budez, P-O, Mamchaoui K, Garcia L, Vaillend C and Goyenvalle A. Long term efficacy of AAV9-U7 snRNA-mediated exon 51 skipping in mdx52 mice. Mol Ther Methods Clin Dev. 2020;17:1037‐1047. 10.1016/j.omtm.2020.04.025
• Barboni MTS, Vaillend C, Joachimsthaler A, Liber AMP, Khabou H, Roux MJ, Vacca O, Vignaud L, Dalkara D, Guillonneau X, Ventura DF, Rendon A, Kremers J. Rescue of defective electroretinographic responses in Dp71-null mice with AAV-mediated reexpression of Dp71. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):11. 10.1167/iovs.61.2.11
• Duarte K, Heide S, Poëa-Guyon S, Rousseau V, Depienne C, Rastetter A, Nava C, Attié-Bitach T, Razavi F, Martinovic J, Moutard ML, Cherfils J, Mignot C, Héron D, Barnier JV. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration. Neurobiol Dis. 2020 Mar; 136:104709. 10.1016/j.nbd.2019.104709
• Castillon C, Gonzalez L, Dominichini F, Guyon S, Da Silva K, Durand C, Lestaevel P, Vaillend C, Laroche S, Barnier JV, Poirier R. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. Human Molecular Genetics. 2020 Jan 16. pii: ddz296. 10.1093/hmg/ddz296


• Vaillend C , Zarrouki F, Vacca O. (2019) Gene therapy for central nervous system in Duchenne muscular dystrophy. Book Chapter 24 in Muscle Gene Therapy Second Edition, edited by Dongsheng Duan and Jerry R. Mendell, Springer books.
• Martucci LL, Amar M, Chaussenot R, Benet G, Bauer O, de Zélicourt A, Nosjean A, Launay JM, Callebert J, Sebrié C, Galione A, Edeline JM, de la Porte S, Fossier P, Granon S, Vaillend C, Cancela JM. (2019) A multiscale analysis in CD38(-/-) mice unveils major prefrontal cortex dysfunctions. FASEB J., 33(5):5823-5835.
• Su M, Naderi K, Samson N, Youssef I, Fülöp L, Bozso Z, Laroche S, Delatour B, Davis S. Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology. Mol Neurobiol. 2019 Jan 25. doi:10.1007/s12035-019-1475-8. [Epub ahead of print] PubMed PMID : 30684218.
• Souttou S, Benabdesselam R, Siqueiros-Marquez L, Sifi M, Deliba M, Vacca O, Charles-Messance H, Vaillend C, Rendon A, Guillonneau X, Dorbani-Mamine L. (2019) Expression and localization of dystrophins and β-dystroglycan in the hypothalamic supraoptic nuclei of rat from birth to adulthood. Acta Histochem, 121(2):218-226. Epub 2018 Dec 28.
• Chaussenot R, Amar M, Fossier P, Vaillend C. (2019) Dp71-Dystrophin Deficiency Alters Prefrontal Cortex Excitation-Inhibition Balance and Executive Functions. Mol Neurobiol, 56(4):2670-2684. Epub 2018 Jul 27.
• Chaalal A, Poirier R, Blum D, Laroche S, Enderlin V (2019) Thyroid hormone supplementation restores spatial memory, hippocampal markers of neuroinflammation, plasticity-related signalling molecules and b-amyloid peptide load in hypothyroid rats. Mol Neurobiol, 56(1):722-735. Epub 2018 May 23.


• Helleringer R, Le Verger D, Li X, Izabelle C, Chaussenot R, Belmaati-Cherkaoui M, Dammak R, Decottignies P, Daniel H, Galante M, Vaillend C (2018) Cerebellar synapse properties and cerebellum-dependent motor and non-motor performance in Dp71-null mice. Dis Model Mech. 11(7).
• Castillon C, Lunion S, Desvignes N, Hanauer A, Laroche S, Poirier R (2018). Selective alteration of adult hippocampal neurogenesis and impaired spatial pattern separation performance in the RSK2-deficient mouse model of Coffin-Lowry syndrome. Neurobiol Dis, 115:69-81.
• Aragón J, González-Reyes M, Romo-Yáñez J, Vacca O, Aguilar-González G, Rendón A, Vaillend C, Montañez C. (2018) Dystrophin Dp71 Isoforms Are Differentially Expressed in the Mouse Brain and Retina : Report of New Alternative Splicing and a Novel Nomenclature for Dp71 Isoforms. Mol Neurobiol, 55(2):1376-1386. Epub 2017 Jan 27.


• Relizani K, Griffith G, Echevarría L, Zarrouki F, Facchinetti P, Vaillend C, Leumann C, Garcia L, Goyenvalle A. (2017) Efficacy and safety profile of tricyclo-DNA antisense oligonucleotides in Duchenne muscular dystrophy mouse model. Molecular Therapy • Nucleic Acids, 8:144-157.
• Vaillend C, Chaussenot R. (2017) Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. Hum Mol Genet, 26(6):1041-1055.
• Maglorius Renkilaraj MR, Baudouin L, Wells CM, Doulazmi M, Wehrlé R, Cannaya V, Bachelin C, Barnier JV, Jia Z, Nait Oumesmar B, Dusart I, Bouslama-Oueghlani L (2017) The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation. Neurobiol Dis ; 98:137-148.


• S. Franchi, V. Astro, R. Macco, D. Tonoli, J.-V. Barnier, M. Botta, I de Curtis (2016) Identification of a protein network driving neuritogenesis of MGE-derived GABAergic interneurons. Frontiers Cell Neurosci, 10:289.
• Miranda R, Laroche S, Vaillend C (2016) Reduced neuronal density in the CA1 anterodorsal hippocampus of the mdx mouse. Neuromuscul Disord ; 26(11) : 775-781.
• Pérez-Núñez R, Barraza N, Gonzalez-Jamett A, Cárdenas AM, Barnier JV, Caviedes P. (2016) Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome : Consequences on Cell Process Formation and Extension. Neurotox Res ;30(1):76-87.
• Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H, Davis S (2016) Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer’s Disease. J Alzheimers Dis. , 51(4):1157-1173.
• Allerborn, M. A., Gros, A., Messaoudi, B., Gervasoni, D., Garcia, S., Thevenet, M., Laroche, S., Veyrac, A. and Ravel, N. (2016). A Novel Task for Studying Memory of Occasional Events in Rats. Bio-protocol 6(5) : e1740.


• Gros A, Veyrac A, Laroche S. [Brain and memory : new neurons to remember]. Biol Aujourdhui. 2015 ;209(3):229-48. French.
• Miranda R, Nagapin F, Bozon B, Laroche S, Aubin T, Vaillend C (2015) Altered social behavior and ultrasonic communication in the dystrophindeficient mdx mouse model of Duchenne muscular dystrophy. Molecular Autism. 6 :60.
• Chaussenot R, Edeline JM, Le Bec B, El Massioui N, Laroche S, Vaillend C. (2015) Cognitive dysfunction in the dystrophin-deficient mouse model of Duchenne muscular dystrophy : A reappraisal from sensory to executive processes. Neurobiol Learn Mem. 124:111-22.
• Veyrac A, Allerborn M, Gros A, Michon F, Raguet L, Kenney J, Godinot F, Thevenet M, Garcia S, Messaoudi B, Laroche S, Ravel N. (2015) Memory of occasional events in rats : individual episodic memory profiles, flexibility, and neural substrate. J Neurosci. 35(19):7575-86.
• Goyenvalle A, Griffith G, Babbs A, El Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. (2015) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med. 21(3):270-5.
• Morel N, Poëa-Guyon S (2015) The membrane domain of vacuolar H(+)ATPase : a crucial player in neurotransmitter exocytotic release. Cell Mol Life Sci. ;72(13):2561-73.


• Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Enderlin E. (2014) PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments. Hippocampus, 24(11) : 1381-1393.pubmed
• Veyrac A, Besnard A, Caboche J, Davis S, Laroche S. (2014) The transcription factor zif268/egr1, brain plasticity and memory. Progress in Molecular Biology and Translational Science, 122 : 89-129. doi : 10.1016/B978-0-12-420170-5.00004-0.pubmed
• Bae S.E, Wright I.K, Wyse C, Samson-Desvignes N, Le Blanc P, Laroche S., Hazlerigg D.G, Johnston J.D. (2014) Regulation of MT1 melatonin receptor expression by gonadotrophin-releasing hormone (GnRH) and early growth response factor-1 (Egr-1) : in vivo and in vitro studies. PLoS One, 9(3) : e90056. doi:10.1371/journal.pone. 0090056.pubmed
• Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G (2014) Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes ;63(1):203-15.
• Morel N, Poëa-Guyon S, Ammar MR, Vitale N (2014) [V-ATPase is a pH sensor controlling vesicular membrane fusion]. Med Sci (Paris) ;30(6-7):631-3.


• Penke Z, Morice E, Veyrac A, Gros A, Chagneau C, LeBlanc P, Samson N, Baumgärtel K, Mansuy IM, Davis S, Laroche S (2013) Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory. Phil. Trans. R. Soc. B, 369(1633) : 20130159.
• Besnard A, Caboche J, Laroche S. (2013) Recall and Reconsolidation of Contextual Fear Memory : Differential Control by ERK and Zif268 Expression Dosage. PLoS One, 8(8):e72006.
• Morice E, Farley S, Poirier R, Dallerac G, Chagneau C, Pannetier S, Hanauer A, Davis S, Vaillend C, Laroche S. (2013) Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiol. Disease, 58 : 156-168.
• Veyrac A, Gros A, Bruel-Jungerman E, Rochefort C, Kleine Borgmann FB, Jessberger S, Laroche S. (2013) Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning. Proc. Natl. Acad. Sci. USA., 110(17):7062-7.pubmed
• Delon-Martin C, Plailly J, Fonlupt P, Veyrac A, Royet JP. (2013) Perfumers’ expertise induces structural reorganization in olfactory brain regions. Neuroimage. 68:55-62.
• Vianello S, Yu H, Voisin V, Haddad H, He X, Foutz AS, Sebrié C, Gillet B, Roulot M, Fougerousse F, Perronnet C, Vaillend C, Matecki S, Escolar D, Bossi L, Israël M, de la Porte S. (2013) Arginine butyrate : a therapeutic candidate for Duchenne muscular dystrophy. FASEB J., 27(6):2256-69.
• Besnard A, Laroche S, Caboche J (2013) Comparative dynamics of MAPK/ERK signalling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and retrieval. Brain Structure and Function, 219(1):415-30.
• Poëa-Guyon S, Ammar MR, Erard M, Amar M, Moreau AW, Fossier P, Gleize V, Vitale N, Morel N (2013) The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery. J Cell Biol ;203(2):283-98.
• Poëa-Guyon S, Pasquier H, Mérola F, Morel N, Erard M (2013) The enhanced cyan fluorescent protein : a sensitive pH sensor for fluorescence lifetime imaging. Anal Bioanal Chem ;405(12):3983-7.


• Gleize V., Boisselier B., Marie Y., Poëa-Guyon S., Sanson S., Morel N., (2012). The renal v-ATPase a4 subunit is expressed in specific subtypes of human gliomas. Glia, 60(6):1004-12.
• Dubos A., Combeau G., Bernardinelli Y., Barnier J-V., Hartley O., Gaertner H., Boda B., Muller D. (2012) Alteration of synaptic network dynamics by the intellectual disability protein PAK3. Journal of Neuroscience, Jan 11 ; 32(2):519 –527.
• G. Combeau, P. Kreis, F. Domenichini, M. Amar, P. Fossier, V. Rousseau, and J.V. Barnier, (2012) The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity. J. Biol. Chem. 287 : 30084-30096.
• Rey NL, Sacquet J, Veyrac A, Jourdan F, Didier A. (2012) Behavioral and cellular markers of olfactory aging and their response to enrichment. Neurobiol Aging. 33(3):626.e9-626.e23.pubmed
• Besnard A, Caboche J, Laroche S. (2012) Reconsolidation of memory : a decade of debate. Progress in Neurobiology, 99 : 61-80.
• Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Miranda HV, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H. (2012) Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol. Aging, 33 : 1122e23-39.
• Perronnet C, Chagneau C, Le Blanc P, Samson-Desvignes N, Mornet D, Laroche S, De La Porte S, Vaillend C. (2012) Upregulation of brain utrophin does not rescue behavioral alterations in dystrophin-deficient mice. Human Molecular Genetics, 21 : 2263-2276.
• Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, Derubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joëls M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ. (2012) Cognitive dysfunction in psychiatric disorders : characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discov. 11(2):141-68.


• Thevenot E, Moreau AW, Rousseau V, Combeau G, Domenichini F, Jacquet C, Goupille O, Amar M, Kreis P, Fossier P, Barnier JV, (2011). p21-activated Kinase 3 (PAK3) Protein Regulates Synaptic Transmission through Its Interaction with the Nck2/Grb4 Protein Adaptor. The Journal of Biological Chemistry, 286(46):40044–59.
• Veyrac A, Wang G, Baum MJ, Bakker J. (2011) The main and accessory olfactory systems of female mice are activated differentially by dominant versus subordinate male urinary odors. Brain Res. 1402:20-29.
• Veyrac A, Wang G, Baum MJ, Bakker J. (2011) CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.PLoS One. 2011 ;6(10):e23721.
• Penke Z., Chagneau C., Laroche S. (2011) Contribution of Egr1/zif268 to Activity-Dependent Arc/Arg3.1 Transcription in the Dentate Gyrus and Area CA1 of the Hippocampus. Front Behav Neurosci. 5:48.
• Dallérac G., Perronnet C., Chagneau C., Leblanc-Veyrac P., Samson N., Peltekian E., Danos O., Garcia L., Laroche S., Billard J.M., Vaillend C. (2011) Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse. Neurobiol. Disease, 43(3):635-641.
• Miranda R., Nudel U., Laroche S., Vaillend C. (2011) Altered presynaptic ultrastructure in excitatory hippocampal synapses of mice lacking dystrophins Dp427 or Dp71. Neurobiol. Disease, 43 : 134-141.
• Cheval H., Chagneau C., Levasseur G., Veyrac A., Faucon-Biguet N., Laroche S., Davis S. (2011) Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory. Hippocampus, 22(3):631-42.


• Moreau A. W., Amar M., Le Roux N., Morel N., Fossier P., (2010) Serotoninergic Fine-Tuning of the Excitation-Inhibition Balance in Rat Visual Cortical Networks. Cerebral Cortex,20 : 456-467.
• Valluet A., Hmitou I., Davis S., Druillennec S., Larcher M., Laroche S., Eychène A. (2010) B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS One, 5(12) : e15272. doi:10.1371/ journal.pone.0015272.pubmed
• Davis S, Renaudineau S, Poirier R, Poucet B, Save E, Laroche S. (2010) The formation and stability of recognition memory : what happens upon recall ? Front Behav Neurosci. 19 ;4:177. 1-11. doi : 10.3389/fnbeh.2010.00177pubmed
• Laroche S. (2010) Cellular and molecular mechanisms of memory. Biol. Aujourd’hui, 204 : 93-102pubmed
• Medvedev NI, Popov VI, Dallerac G, Davies HA, Laroche S, Kraev I, Rodriguez-Arellano J, Doyère V, Stewart MG. (2010) Alterations in synaptic curvature in the dentate gyrus following induction of LTP, LTD, and treatment with the NMDA receptor antagonist CPP, Neuroscience, 171 : 390-397.pubmed
• Brock O, Keller M, Veyrac A, Douhard Q, Bakker J. (2010) Short term treatment with estradiol decreases the rate of newly generated cells in the subventricular zone and main olfactory bulb of adult female mice. Neuroscience, 166(2) : 368-376.pubmed
• Vaillend C, Perronnet C, Ros C, Gruszczynski C, Goyenvalle A, Laroche S, Danos O, Garcia L, Peltekian E. (2010) Rescue of a dystrophin-like protein by exon skipping in vivo restores GABAA-receptor clustering in the hippocampus of the mdx mouse. Molecular therapy Advance Online publication, doi:10.1038/mt.2010.134.pubmed
• Perronnet C, Vaillend C. (2010) Dystrophins, utrophins and associated scaffolding complexes : Role in mammalian brain and implications for therapeutic strategies. Journal of Biomedicine and Biotechnology, Article ID 849426. doi:10.1155/2010/849426.pubmed
• Ghenimi N., Alfos S, Redonnet A., Higueret P., Pallet V., Enderlin V. (2010) Adult-onset hypothyroidism induces the amyloidogenic pathway of APP processing in the rat hippocampus. J. Neuroendocrinol., in press, doi : 10.1111/j.1365-2826.2010.02002.x.pubmed
• Medvedev N.I., Popov V.I., Rodriguez Arellano J.J, Dallérac G, Davies H.A., Gabbott P.L, Laroche S., Kraev, I.V, Doyère V., Stewart M.G. (2010) The NMDA receptor antagonist CPP alters synapse and spine structure and impairs LTP and LTD induced morphological plasticity in dentate gyrus of the awake rat. Neuroscience, 165 : 1170-1181.pubmed
• Languille S, Richer P, Hars B. (2010) Abrupt emergence of long-lasting memory in the pre-weanling rat. Behav. Brain Res., 207 : 515-519.


• Kreis P., Barnier J.-V., (2009) PAK signalling in neuronal physiology, Cellular Signalling, 21(3) : 384-93.
• Veyrac A, Sacquet J, Nguyen V, Marien M, Jourdan F, Didier A. (2009) Novelty determines the effects of olfactory enrichment on memory and neurogenesis through noradrenergic mechanisms. Neuropsychopharmacology. 34(3) : 786-795.pubmed
• Bovetti S, Veyrac A, Peretto P, Fasolo A, De Marchis S. (2009) Olfactory enrichment influences adult neurogenesis modulating GAD67 and plasticity-related molecules expression in newborn cells of the olfactory bulb. PLoS One. 4(7) : e6359.pubmed
• Vallortigara J., Chassande O., Higueret P., Enderlin V. (2009) The normalization of adult-onset hypothyroidism-related hypoexpression of synaptic plasticity target genes in striatum. J. Neuroendocrinol., 21 : 49-56.pubmed
• Beauvieux MC., Ghenimi Rahab N., Raffard G., Enderlin V., Pallet V., Higueret P., Gallis JL. (2009) The Early Decrease in N-Acetyl Aspartate / Glutathione, a Brain Health Marker, Induced by Vitamin A Deprivation in Rat is Reversed by Retinoic Acid. The Open Magnetic Resonance Journal, 2 : 71-79.
• Bruel-Jungerman E., Veyrac A., Dufour F., Horwood J., Laroche S., Davis S. (2009) Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. PLoS One, 4(11) : e7901.pubmed
• Renaudineau S., Poucet B., Laroche S., Davis S., Save E. (2009) Impaired long term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1. Proc. Natl. Acad. Sci USA., 106 : 11771-11775.pubmed
• Languille S, Richer P, Hars B. (2009) Approach memory turns to avoidance memory with age. Behav. Brain Res., 202 : 278-284.pubmed
• Coureaud G, Languille S, Schaal B, Hars B. (2009) Pheromone-induced olfactory memory in newborn rabbits : Involvement of consolidation and reconsolidation processes. Learning & Memory, 16 : 470-473.pubmed
• Languille S., Davis S., Richer P., Alcacer C., Laroche S., Hars B. (2009) ERK activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis. Eur. J. Neurosci., 30 : 1923-1930.pubmed
• Daoud F, Candelario-Martínez A, Billard JM, Avital A, Khelfaoui M, Rozenvald Y, Guegan M, Mornet D, Jaillard D, Nudel U, Chelly J, Martínez-Rojas D, Laroche S, Yaffe D, Vaillend C. (2009) Role of mental retardation-associated dystrophin-gene product Dp71 in excitatory synapse organization, synaptic plasticity and behavioral functions. PLoS One. 4(8):e6574.pubmedabstract
• Miranda R., Sébrié C., Degrouard J., Gillet B., Jaillard D., Laroche S., Vaillend C. (2009) Reorganization of inhibitory synapses and increased PSD length of perforated-excitatory synapses in hippocampal area CA1 of dystrophin-deficient mdx mice. Cerebral Cortex. 19(4):876-88pubmedabstract


• Kreis P., Rousseau V., Thévenot E., Combeau G., Barnier J.-V., (2008) The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties., Journal of Neurochemistry, 106(3) : 1184-97.
• Vallortigara J., Alfos S., Micheau J., Higueret P., Enderlin V. (2008). T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior. Neurobiology of Disease 31, 378–385.
• Soulé J., Penke Z., Alme M.N., Kanhema T., Laroche S., Bramham C.R. (2008) Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. Neural Plasticity. In Press.pubmed
• Chardonnet S., Le Marechal P., Cheval H., Le Caer J.P., Decottignies P., Laprevote O., Laroche S., Davis S. (2008) Large-scale study of phosphoproteins involved in long-term potentitation in the rat dentate gyrus in vivo. Eur. J. Neurosci. 27 : 2985-2998.
• Poirier R., Cheval H., Mailhes C., Garel S., Charnay P., Davis S., Laroche S. (2008) Distinct functions of Egr gene family members in cognitive processes. Frontiers in Neuroscience 2 : 47-55.pubmed
• Languille S, Richer P, Hars B. (2008) The temporal dynamics of consolidation and reconsolidation decrease during post-natal development. Learning & Memory., 15 : 434-442.pubmed
• Vaillend C., Poirier R., Laroche S. (2008) Genes, Plasticity and Mental Retardation. Behav. Brain Res. 192 : 88-105.pubmed


• Kreis P., Thévenot E., Rousseau V., Boda B., Muller D., Barnier J.-V., (2007) The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway., The Journal of Biological Chemistry, 282(29) : 21497-506.
• Poirier R., Cheval H., Mailhes C., Charnay P., Davis S., Laroche S. (2007) Paradoxical role of an Egr transcription factor family member, Egr2/Krox20, in learning and memory. Front. Behav. Neurosci. 1 : 1-12.pubmed
• Chardonnet S., Decottignies P., Amar L., Le Caer J.P., Davis S., Laroche S., Le Maréchal P. (2007) New mortalin and histidyl tRNA synthetase isoforms point out a pitfall in proteomic analysis of Egr1 genetically modified mice. Proteomics, 7 : 289-298.pubmed
• Bruel-Jungerman E., Rampon C., Laroche S. (2007) Adult hippocampal neurogenesis, synaptic platicity and memory : Facts and hypotheses. Rev. Neurosci. 18 : 93-114.pubmed
• Sipos E., Kurunczi A., Kasza A., Horváth J., Felszeghy K., Laroche S., Toldi J., Párducz A., Penke B., Penke Z. (2007) ß-Amyloid pathology in the entorhinal cortex of rats induces memory deficits : implications for Alzheimer’s disease. Neuroscience, 147 : 28-36.pubmed
• Bruel-Jungerman E., Davis S., Laroche S. (2007) Brain Plasticity Mechanisms and Memory : A Party of Four. Neuroscientist, 13(5) : 492-505.pubmed
• Poirier R, Jacquot S., Vaillend C., Soutthiphong AA., Libbey M., Davis S., Laroche S., Hanauer A., Welzl H., Lipp, HP. Wolfer DP. (2007) Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior. Behav Genetics, 37 : 31-50.pubmed


• Poëa-Guyon S., Amar M., Fossier P., Morel N., (2006) Alternative splicing controls neuronal expression of v-ATPase subunit a1 and sorting to nerve terminals., Journal of Biological Chemistry, 281(25) : 17164-72.
• Romano D., Pertuit M., Rasolonjanahary R., Barnier J.-V., Magalon K., Enjalbert A., Gerard C., (2006) Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/Akt pathway in pituitary cells, Endocrinology, 147(12) : 6036-45.
• Boucheron C., Alfos S., Enderlin V., Husson M., Pallet V., Jaffard R., Higueret P. (2006). Age-related effects of ethanol consumption on triiodothyronine and retinoic acid nuclear receptors, neurogranin and neuromodulin expression levels in mouse brain. Neurobiology of Aging 27, 1326-1334.
• Husson M., Enderlin V., Delacourte A., Alfos S., Ghenimi N., Pallet V., Higueret P. (2006). Retinoic acid normalizes the nuclear receptors mediated hypoexpression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats. Neurobiology of Disease 23, 1-10
• Bruel-Jungerman E., Davis S., Rampon C. and Laroche S. (2006) Long-term potentiation enhances neurogenesis in the adult dentate gyrus. J. Neurosci., 26 : 5888-5893.pubmed
• Horwood J.M., Dufour F., Laroche S., Davis S. (2006) Signalling mechanisms mediated by the PI3 kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur. J. Neurosci., 23 : 3375-3384.pubmed
• Laroche S. (2006) Mécanismes cellulaires et moléculaires de la mémoire. Epilepsies, 18 : 15-20.
• Bliss T.V.P., Collingridge G.L., Laroche S. (2006) ZAP and ZIP, a story to forget. Science, 313 : 1058-1059.pubmed
• Davis S. and Laroche S. (2006) MAP kinase/ERK signalling and memory stabilisation : a review. Gene, Brain Behav., 5 : 61-72.pubmed


• Féart C., Vallortigara J., Higueret D., Gatta B., Tabarin A., Enderlin V., Higueret P., Pallet V. (2005). Decreased expression of retinoid nuclear receptors (RARα and RARγ) mRNA determined by real-time quantitative RT-PCR in peripheral blood mononuclear cells of hypothyroid patients. Journal of Molecular Endocrinology 34, 849-858.
• Féart C., Mingaud F., Enderlin V., Husson M., Alfos S., Higueret P., Pallet V. (2005). Differential effect of retinoic acid and triiodothyronine on the age-related hypo-expression of neurogranin in rat. Neurobiology of Aging 26, 729-738.
• Bruel-Jungerman E., Laroche S. & Rampon C. (2005) New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur. J. Neurosci., 21 : 513-521.pubmed


• Vaillend C., Billard J.M. & Laroche S. (2004) Impaired long-term spatial and recognition memory and enhanced CA1 hippocampal LTP in the dystrophin-deficient Dmdmdx mouse. Neurobiol. Disease, 17 : 10-20.pubmed
• Gruest N., Richer P. & Hars B. (2004) Memory consolidation and reconsolidation in the rat pup require protein synthesis. J. Neurosci., 24 : 10488-10492.pubmed
• Gruest N, Richer P, Hars B. Emergence of long term memory for conditioned aversion in the rat fetus. Developmental Psychobiology.pubmed
• O’Connor, V., Genin, A., Davis, S., Karishma, K.K., Doyère, V., De Zeeuw, C.I., Sanger, G., Hunt, S.P., Richter-Levin, G., Mallet, J., Laroche, S., Bliss, T.V.P. & French, P.J. (2004) Differential amplification of intron containing transcripts reveals LTP-associated upregulation of specific Pde10A phosphodiesterase splice variants. J. Biol. Chem.pubmed
• Mezey, S., Doyère, V., De Souza, I., Harrison, E., Cambon, K., Kendal, C., Davies, H., Laroche, S. & Stewart, M. (2004) Long-term synaptic morphometry changes after induction of LTP and LTD in the dentate gyrus of awake rats are not simply mirror phenomena. Eur. J. Neurosci.pubmed


• Rousseau V., Goupille O., Morin N., Barnier J.-V., (2003) A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases., The Journal of Biological Chemistry, 278(6) : 3912-20.
• Morel N., (2003) Neurotransmitter release : the dark side of the vacuolar-H+ATPase., Biology of the Cell, 95(7) : 453-7.
• Morel N., Dedieu J.-C., Philippe J.-M., (2003) Specific sorting of the a1 isoform of the V-H+ATPase a subunit to nerve terminals where it associates with both synaptic vesicles and the presynaptic plasma membrane., Journal of Cell Science, 116(23) : 4751-62.
• Castell X., Cheviron N., Barnier J.-V., Diebler M.-F., (2003) Exploring the regulation of the expression of ChAT and VAChT genes in NG108-15 cells : implication of PKA and PI3K signaling pathways., Neurochemical Research, 28(3-4) : 557-64.
• Bozon B., Davis S. and Laroche S. A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron. 2003, 40 : 695-701.pubmed
• Stéphan, A., Laroche, S. and Davis, S. 2003 ; Learning deficits and dysfunctional synaptic plasticity induced by aggregated amyloid deposits in the dentate gyrus are rescued by chronic treatment with indomethacin. Eur. J. Neurosci., 17 : 1921-1927.pubmed
• Kelly A., Laroche S. and Davis S. 2003 ; Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory, J. Neurosci., 12 : 5354-5360.pubmed
• Davis S, Bozon B, Laroche S. How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning ? Behav. Brain Res. 2003 ; 142 : 17-30.pubmed
• Génin A, French P, Doyère V, Davis S, Errington ML, Maroun M, Stean T, Truchet B, Webber M, Wills T, Richter-Levin G, Sanger G, Hunt SP, Mallet J, Laroche S, Bliss TVP, O’Connor V. LTP but not seizure is associated with up-regulation of AKAP-150. Eur. J. Neurosci. 2003 ; 17 : 331-340.pubmed
• Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Phil. Trans. R. Soc. 2003 ; 358 : 805-814.pubmed
• Davis S, Laroche S. What can rodent models tell us about cognitive decline in Alzheimer’s disease. Mol. Neurobiol. 2003 ; 27 : 249-276.pubmed


• Morel N., Philippe J.-M., (2002) La libération des neuromédiateurs : le double jeu de la V-ATPase. [Neurotransmitter release : the dark side of the V-ATPase], M/S • Medecine sciences, 18(11) : 1121-5.
• Philippe J.-M., Dubois J.-M., Rouzaire-Dubois B., Cartron P.-F., Vallette F., Morel N., (2002) Functional expression of V-ATPases in the plasma membrane of glial cells., Glia, 37(4) : 365-73.
• Vaillend C, Billard, JM. Facilitated CA1 hippocampal synaptic plasticity in dystrophin-deficient mice : Role for GABAA receptors ? Hippocampus. 2002 ; 12(6) : 713-717.pubmed
• Dutar P, Vaillend C, Viollet C, Billard JM, Potier B, Carlo AS, Ungerer A, Epelbaum J. Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice. Neuroscience. 2002 ; 112(2):455-66.pubmed
• Vaillend C, Mason SE, Cuttle MF, Alger BE. Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na(+)-K(+)-ATPases in the rat CA1 hippocampal region. J. Neurophysiol. 2002 ; 88(6):2963-2978.pubmed
• Vaillend C, Rampon C, Davis S, Laroche S. Gene control of synaptic plasticity and memory formation : Implications for diseases and therapeutic strategies. Curr. Mol. Med. 2002 ; 2(7):613-628.pubmed
• Bozon B, Davis S, Laroche S. Regulated transcription of the immediate early gene Zif268 : mechanisms and gene dosage-dependent function in synaptic plasticity and memory formation. Hippocampus. 2002 ; 12(5):570-577.pubmed
• Salin H, Maurin Y, Davis S, Laroche S, Mallet J, Dumas S. Spatio-temporal heterogeneity and cell-specificity of long-term potentiation-induced mRNA expression in the dentate gyrus in vivo. Neuroscience 2002 ;110(2):227-236.pubmed
• Stéphan A, Davis S, Salin H, Dumas S, Mallet J, Laroche S. Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity. Hippocampus. 2002 ; 12 : 55-62.pubmed


• Laroche S. Cellular and molecular mechanisms of memory. J. Soc. Biol. 2001 ;195(4):363-373.pubmed
• Genin A, Davis S, Meziane H, Doyère V, Jeromin A, Roder J, Mallet J, Laroche S. Regulated expression of the neuronal calcium sensor-1 gene during long-term potentiation in the dentate gyrus in vivo. Neuroscience. 2001 ;106(3):571-7.pubmed
• Stéphan A, Laroche S, Davis S. Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J Neurosci. 2001 Aug 1 ;21(15):5703-14.pubmed
• French PJ, O’Connor V, Jones MW, Davis S, Errington ML, Voss K, Truchet B, Wotjak C, Stean T, Doyère V, Maroun M, Laroche S, Bliss TVP. Subfield-specific immediate early gene expression associated with hippocampal long-term potentiation in vivo. Eur J Neurosci. 2001 Mar ;13(5):968-76.pubmed
• Jones MW, Errington ML, French PJ, Fine A, Bliss TV, Garel S, Charnay P, Bozon B, Laroche S, Davis S. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci. 2001 Mar ;4(3):289-96.pubmed
• Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ. Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces. Neuron. 2001 Dec 6 ;32(5):911-926.pubmed


• Laroche S. Cellular and molecular approaches to memory storage. Therapie. 2000 Jul-Aug ;55(4):461-6. Review.pubmed
• Davis S, Salin H, Helme-Guizon A, Dumas S, Stéphan A, Corbex M, Mallet J, Laroche S. Dysfunctional regulation of alphaCaMKII and syntaxin 1B transcription after induction of LTP in the aged rat. Eur J Neurosci. 2000 Sep ;12(9):3276-82.pubmed
• Laroche S, Davis S, Jay TM. Plasticity at hippocampal to prefrontal cortex synapses : dual roles in working memory and consolidation. Hippocampus. 2000 ;10(4):438-46. Review.pubmed
• Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J Neurosci. 2000 Jun 15 ;20(12):4563-72.pubmed
• Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci. 2000 Mar ;3(3):238-44.pubmed
• Viollet C, Vaillend C, Videau C, Bluet-Pajot MT, Ungerer A, L’Heritier A, Kopp C, Potier B, Billard J, Schaeffer J, Smith RG, Rohrer SP, Wilkinson H, Zheng H, Epelbaum J. Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice. Eur J Neurosci. 2000 Oct ;12(10):3761-70.pubmed