Animal behaviour PSI-CO
The NeuroPSI animal behaviour platform, PSI-CO, provides NeuroPSI as well as external teams, a set of behavioural tests adapted to aquatic and rodent models.
For more information or to request a quote, please contact Cynthia FROC.
Our complete and innovative battery of tests will allow you to explore spontaneous behaviours (locomotion, exploration), anxiety-like behaviours, social behaviours, and various cognitive functions (learning, memory, risk-taking …) in your study models.
Our platform has several areas dedicated to the study of behavioural phenotypes, which are equipped with various behavioural setups, coupled with cameras and ANY-maze or Viewpoint video monitoring software.
To meet the needs of neuroscience experimenters, surgery rooms, injection rooms and perfusion rooms are also available. The aquatic section also offers housing options adaptable to many species such as Danio rerio, Oryzias latipes and cichlids.
Teleost fishes have a behavioural repertoire which is relatively similar to that of mammals and birds, and which is better and better described in the literature. The use of fish in neuroscience has the advantage of a large availability of genetic tools that make them the models of choice today (e.g. zebrafish). These neurogenetic approaches, combined with our expertise, will allow you to understand better the mechanisms underlying the behaviours of interest in your experimental models.
Rodents are the most widely used model organisms in neuroscience. They offer many advantages, in large part because they are physiologically similar to humans. The availability of multiple complementary behavioural approaches for analysing the same cognitive/behavioural parameter allows for a robust interpretation of the experimental results.
Cynthia FROC – Engineer, CNRS
Alessandro ALUNNI – Researcher, CNRS
Glenn DALLÉRAC – Researcher, CNRS
Roseline POIRIER – Associate Professor, UPSaclay
LThe services offered by the PSI-CO platform will be adapted to your needs and your model.
For aquatic and rodent models, three categories of tests are available:
- Studies of spontaneous behaviours (motor skills, locomotion, exploration, anxiety, etc.)
- Tests based on social behaviours (social interactions, aggressiveness, etc.)
- Cognitive tests (conditioning, different types of memory, decision making, etc.)
- Measurement of locomotor activity in adults and larvae
- Passive avoidance in adults
- Decision making in a choice test in adults
- Alternation in T-maze
- Spatial learning by visual discrimination
- Associative learning: Matching-to-sample and Delay-Matching-to-sample
- Measurement of aggression in adults (Mirror test)
- Sociability test in adults and larvae (shoaling test in larvae)
Motor and spontaneous behaviours
- Locomotion and motor coordination test in Rotarod
- Elevated cross maze.
- Morris pool (mouse or rat)
- Object recognition tests
- Contextual or indicative conditioned fear test
- Passive avoidance test
- Prepulse inhibition
- Intellicage (mouse)
- Customized tests (e.g. resident-intruder in open field)
Behavioural Brain Research
Solal Bloch, Cynthia Froc, Anaïs Pontiggia, Kei Yamamoto
Existence of working memory in teleosts : Establishment of the delayed matching-to-sample task in adult zebrafish
Prog Neuropsychopharmacol Biol Psychiatry
Lange M, Froc C, Grunwald H, Norton WHJ, Bally-Cuif L
Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity
Bhattarai P, Thomas AK, Cosacak MI, Papadimitriou C, Mashkaryan V, Froc C, Reinhardt S, Kurth T, Dahl A, Zhang Y, Kizil C
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain
Lange M, Neuzeret F, Fabreges B, Froc C, Bedu S, Bally-Cuif L, Norton WH
Inter-individual and inter-strain variations in zebrafish locomotor ontogeny