Institut NeuroPSI - UMR9197
CNRS Université Paris-Saclay
Campus CEA Saclay
Saclay, FRANCE
Dr. Luc Estebanez
Research Scientist
Sensori-motor Integration & Plasticity
luc.estebanez cnrs.fr
+33(0)1 69 82 34 60, room 3119
ORCID : 0000-0001-6253-7637
X-Twitter : @LucEstebanez
Research interests
How can large and complex streams of artificial, direct inputs to the brain be integrated in the context of a brain-machine interface? To explore the “grammar” of the brain, we have developed a brain-machine interface in head-fixed mice, based on the readout of electrophysiological activity in the primary motor cortex, while feedback is provided to the mice using distributed, spatially and temporally patterned optogenetic stimulations of the surface of the primary somatosensory cortex. This is a team effort with three doctoral students – Aamir Abbasi, Dorian Goueytes and Henri Lassagne – and in collaboration with Valérie Ego-Stengel.
Based on this experimental device, we study the impact of the spatio-temporal structure of cortical stimulations on their integration into motor control. With PhD students Edouard Ferrand and Zineb Hayatou, I extend this work through the recent development of a miniaturized mouse forelimb prosthesis, which will allow us to explore the impact of artificial feedback in the context of the control of a neuroprosthesis, as well as study the embodiment of this prosthesis.
In parallel to these efforts to understand the rules of artificial input integration and their impact on neuroprosthetics, we are exploring an innovative strategy towards the motor control of neuroprostheses via a readout in real-time of the mesoscale cortical wave dynamics, using genetically encoded calcium probe imaging in mice. This is work that I am carrying with post-doctoral researcher Anton Dogadov and doctoral student Clément Picard, in collaboration with Isabelle Ferezou and Valérie Ego-Stengel.
Funding
This research is supported by the Foundation for Brain Research (FRC), the Foundation for Medical Research (FRM), the French National Agency for Research (ANR, JCJC funding), the CNRS (80|Prime funding) , the 3DS Foundation, and Université Paris-Saclay (I-Code and H-Code funding).
Journal articles
2023
- ref_biblio
- Aamir Abbasi, Henri Lassagne, Luc Estebanez, Dorian Goueytes, Daniel Shulz, et al.. Brain-machine interface learning is facilitated by specific patterning of distributed cortical feedback. Science Advances , 2023, 9 (38), pp.eadh1328. ⟨10.1126/sciadv.adh1328⟩. ⟨hal-04220009⟩
- Accès au texte intégral et bibtex
-
2022
- ref_biblio
- Dorian Goueytes, Henri Lassagne, Daniel Shulz, Valérie Ego-Stengel, Luc Estebanez. Learning in a closed-loop brain-machine interface with distributed optogenetic cortical feedback. Journal of Neural Engineering, 2022, 19 (6), pp.066045. ⟨10.1088/1741-2552/acab87⟩. ⟨hal-03915216v2⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Henri Lassagne, Dorian Goueytes, Daniel Shulz, Luc Estebanez, Valérie Ego-Stengel. Continuity within the somatosensory cortical map facilitates learning. Cell Reports, 2022, 39 (1), pp.110617. ⟨10.1016/j.celrep.2022.110617⟩. ⟨hal-03633778⟩
- Accès au texte intégral et bibtex
-
2018
- ref_biblio
- Aamir Abbasi, Dorian Goueytes, Daniel E. Shulz, Valérie Ego-Stengel, Luc Estebanez. A fast intracortical brain–machine interface with patterned optogenetic feedback. Journal of Neural Engineering, 2018, 15 (4), pp.046011. ⟨10.1088/1741-2552/aabb80⟩. ⟨hal-02061575⟩
- Accès au bibtex
-
- ref_biblio
- Luc Estebanez, Isabelle Ferezou, Valérie Ego-Stengel, Daniel E. Shulz. Representation of Tactile Scenes in the Rodent Barrel Cortex. Neuroscience, 2018, 368, pp.81-94. ⟨10.1016/j.neuroscience.2017.08.039⟩. ⟨hal-02061511⟩
- Accès au texte intégral et bibtex
-
- ref_biblio
- Matías Goldin, Evan R. Harrell, Luc Estebanez, Daniel E. Shulz. Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2. Nature Communications, 2018, 9 (1), pp.4053. ⟨10.1038/s41467-018-06585-4⟩. ⟨hal-02193426⟩
- Accès au bibtex
-
- ref_biblio
- Maria Eugenia Vilarchao, Luc Estebanez, Daniel E. Shulz, Isabelle Ferezou. Supra-barrel Distribution of Directional Tuning for Global Motion in the Mouse Somatosensory Cortex. Cell Reports, 2018, 22 (13), pp.3534-3547. ⟨10.1016/j.celrep.2018.03.006⟩. ⟨hal-02061541⟩
- Accès au texte intégral et bibtex
-
2017
- ref_biblio
- Luc Estebanez, Diana Hoffmann, Birgit Voigt, James F.A. Poulet. Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching. Cell Reports, 2017, 20 (2), pp.308-318. ⟨10.1016/j.celrep.2017.06.044⟩. ⟨hal-02061522⟩
- Accès au bibtex
-
- ref_biblio
- Christiane Wetzel, Simone Pifferi, Cristina Picci, Caglar Gök, Diana Hoffmann, et al.. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neuroscience, 2017, 20 (2), pp.209-218. ⟨10.1038/nn.4454⟩. ⟨hal-02061440⟩
- Accès au bibtex
-
2016
- ref_biblio
- Luc Estebanez, Julien Bertherat, Daniel E. Shulz, Laurent Bourdieu, Jean-Francois Leger. A radial map of multi-whisker correlation selectivity in the rat barrel cortex. Nature Communications, 2016, 7, pp.13528. ⟨10.1038/ncomms13528⟩. ⟨hal-01403564⟩
- Accès au bibtex
-
2015
- ref_biblio
- Luc Estebanez, James F.A. Poulet, Jens Kremkow. Matching Cell Type to Function in Cortical Circuits. Neuron, 2015, 87 (2), pp.249-251. ⟨10.1016/j.neuron.2015.06.039⟩. ⟨hal-02060698⟩
- Accès au bibtex
-
2014
- ref_biblio
- Luc Estebanez, Sami El Boustani, Alain Destexhe, Daniel Shulz. [What the whiskers tell the tactile brain].. Médecine/Sciences, 2014, 30 (1), pp.93-8. ⟨10.1051/medsci/20143001019⟩. ⟨hal-01055316⟩
- Accès au bibtex
-
- ref_biblio
- Jean-Sébastien Jouhanneau, Leiron Ferrarese, Luc Estebanez, Nick J. Audette, Michael Brecht, et al.. Cortical fosGFP Expression Reveals Broad Receptive Field Excitatory Neurons Targeted by POm. Neuron, 2014, 84 (5), pp.1065-1078. ⟨10.1016/j.neuron.2014.10.014⟩. ⟨hal-02066075⟩
- Accès au bibtex
-
2012
- ref_biblio
- Francesca Anselmi, Julien Bertherat, Luc Estebanez, Marcel van 'T Hoff, Kathleen Zylbersztejn. An interdisciplinary learning experience in neuro-optics.. Journal of Physiology - Paris, 2012, 106 (3-4), pp.58-61. ⟨10.1016/j.jphysparis.2012.01.002⟩. ⟨hal-00850605⟩
- Accès au bibtex
-
- ref_biblio
- Luc Estebanez, Sami El Boustani, Alain Destexhe, Daniel Shulz. Correlated input reveals coexisting coding schemes in a sensory cortex.. Nature Neuroscience, 2012, 15 (12), pp.1691-9. ⟨10.1038/nn.3258⟩. ⟨hal-00850571⟩
- Accès au bibtex
-
2011
- ref_biblio
- Julie Le Cam, Luc Estebanez, Vincent Jacob, Daniel Shulz. Spatial structure of multiwhisker receptive fields in the barrel cortex is stimulus dependent.. Journal of Neurophysiology, 2011, 106 (2), pp.986-98. ⟨10.1152/jn.00044.2011⟩. ⟨hal-00635975⟩
- Accès au bibtex
-
2010
- ref_biblio
- Vincent Jacob, Luc Estebanez, Julie Le Cam, Jean-Yves Tiercelin, Patrick Parra, et al.. The Matrix: a new tool for probing the whisker-to-barrel system with natural stimuli.. Journal of Neuroscience Methods, 2010, 189 (1), pp.65-74. ⟨10.1016/j.jneumeth.2010.03.020⟩. ⟨hal-00502608⟩
- Accès au bibtex
-
Theses
2011
- ref_biblio
- Luc Estebanez. Characterization of the sensory processings in the barrel cortex of the anaesthetized rat.. Neurobiology. Ecole Normale Supérieure de Paris - ENS Paris, 2011. English. ⟨NNT : ⟩. ⟨tel-00696553⟩
- Accès au texte intégral et bibtex
-
