Institut NeuroPSI - UMR9197
CNRS Université Paris-Saclay
Campus CEA Saclay
Saclay, FRANCE
Dr. Luc Estebanez
Research Scientist
Sensori-motor Integration & Plasticity
luc.estebanez cnrs.fr
+33(0)1 69 82 34 60, room 3119
ORCID : 0000-0001-6253-7637
Twitter : @LucEstebanez
Research interests
How can large and complex streams of artificial, direct inputs to the brain be integrated in the context of a brain-machine interface? To explore the “grammar” of the brain, we have developed a brain-machine interface in head-fixed mice, based on the readout of electrophysiological activity in the primary motor cortex, while feedback is provided to the mice using distributed, spatially and temporally patterned optogenetic stimulations of the surface of the primary somatosensory cortex. This is a team effort with three doctoral students – Aamir Abbasi, Dorian Goueytes and Henri Lassagne – and in collaboration with Valérie Ego-Stengel.
Based on this experimental device, we study the impact of the spatio-temporal structure of cortical stimulations on their integration into motor control. With PhD students Edouard Ferrand and Zineb Hayatou, I extend this work through the recent development of a miniaturized mouse forelimb prosthesis, which will allow us to explore the impact of artificial feedback in the context of the control of a neuroprosthesis, as well as study the embodiment of this prosthesis.
In parallel to these efforts to understand the rules of artificial input integration and their impact on neuroprosthetics, we are exploring an innovative strategy towards the motor control of neuroprostheses via a readout in real-time of the mesoscale cortical wave dynamics, using genetically encoded calcium probe imaging in mice. This is work that I am carrying with post-doctoral researcher Anton Dogadov and doctoral student Clément Picard, in collaboration with Isabelle Ferezou and Valérie Ego-Stengel.
Funding
This research is supported by the Foundation for Brain Research (FRC), the Foundation for Medical Research (FRM), the French National Agency for Research (ANR, JCJC funding), the CNRS (80|Prime funding) , the 3DS Foundation, and Université Paris-Saclay (I-Code and H-Code funding).
Journal articles
2022
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- Dorian Goueytes, Henri Lassagne, Daniel Shulz, Valérie Ego-Stengel, Luc Estebanez. Learning in a closed-loop brain-machine interface with distributed optogenetic cortical feedback. Journal of Neural Engineering, 2022, 19 (6), pp.066045. ⟨10.1088/1741-2552/acab87⟩. ⟨hal-03915204⟩
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- Dorian Goueytes, Henri Lassagne, Daniel Shulz, Valérie Ego-Stengel, Luc Estebanez. Learning in a closed-loop brain-machine interface with distributed optogenetic cortical feedback. Journal of Neural Engineering, 2022, 19 (6), pp.066045. ⟨10.1088/1741-2552/acab87⟩. ⟨hal-03915216⟩
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- Henri Lassagne, Dorian Goueytes, Daniel Shulz, Luc Estebanez, Valérie Ego-Stengel. Continuity within the somatosensory cortical map facilitates learning. Cell Reports, 2022, 39 (1), pp.110617. ⟨10.1016/j.celrep.2022.110617⟩. ⟨hal-03633778⟩
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2018
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- Aamir Abbasi, Dorian Goueytes, Daniel E. Shulz, Valérie Ego-Stengel, Luc Estebanez. A fast intracortical brain–machine interface with patterned optogenetic feedback. Journal of Neural Engineering, 2018, 15 (4), pp.046011. ⟨10.1088/1741-2552/aabb80⟩. ⟨hal-02061575⟩
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- Luc Estebanez, Isabelle Ferezou, Valérie Ego-Stengel, Daniel E. Shulz. Representation of Tactile Scenes in the Rodent Barrel Cortex. Neuroscience, 2018, 368, pp.81-94. ⟨10.1016/j.neuroscience.2017.08.039⟩. ⟨hal-02061511⟩
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- Matías Goldin, Evan R. Harrell, Luc Estebanez, Daniel E. Shulz. Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2. Nature Communications, 2018, 9 (1), pp.4053. ⟨10.1038/s41467-018-06585-4⟩. ⟨hal-02193426⟩
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- Maria Eugenia Vilarchao, Luc Estebanez, Daniel E. Shulz, Isabelle Ferezou. Supra-barrel Distribution of Directional Tuning for Global Motion in the Mouse Somatosensory Cortex. Cell Reports, 2018, 22 (13), pp.3534-3547. ⟨10.1016/j.celrep.2018.03.006⟩. ⟨hal-02061541⟩
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2017
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- Luc Estebanez, Diana Hoffmann, Birgit Voigt, James F.A. Poulet. Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching. Cell Reports, 2017, 20 (2), pp.308-318. ⟨10.1016/j.celrep.2017.06.044⟩. ⟨hal-02061522⟩
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- Christiane Wetzel, Simone Pifferi, Cristina Picci, Caglar Gök, Diana Hoffmann, et al.. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neuroscience, 2017, 20 (2), pp.209-218. ⟨10.1038/nn.4454⟩. ⟨hal-02061440⟩
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2016
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- Luc Estebanez, Julien Bertherat, Daniel E. Shulz, Laurent Bourdieu, Jean-Francois Leger. A radial map of multi-whisker correlation selectivity in the rat barrel cortex. Nature Communications, 2016, 7, pp.13528. ⟨10.1038/ncomms13528⟩. ⟨hal-01403564⟩
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2015
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- Luc Estebanez, James F.A. Poulet, Jens Kremkow. Matching Cell Type to Function in Cortical Circuits. Neuron, 2015, 87 (2), pp.249-251. ⟨10.1016/j.neuron.2015.06.039⟩. ⟨hal-02060698⟩
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2014
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- Luc Estebanez, Sami El Boustani, Alain Destexhe, Daniel Shulz. [What the whiskers tell the tactile brain].. médecine/sciences, 2014, 30 (1), pp.93-8. ⟨10.1051/medsci/20143001019⟩. ⟨hal-01055316⟩
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- Jean-Sébastien Jouhanneau, Leiron Ferrarese, Luc Estebanez, Nick J. Audette, Michael Brecht, et al.. Cortical fosGFP Expression Reveals Broad Receptive Field Excitatory Neurons Targeted by POm. Neuron, 2014, 84 (5), pp.1065-1078. ⟨10.1016/j.neuron.2014.10.014⟩. ⟨hal-02066075⟩
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2012
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- Francesca Anselmi, Julien Bertherat, Luc Estebanez, Marcel van 'T Hoff, Kathleen Zylbersztejn. An interdisciplinary learning experience in neuro-optics.. Journal of Physiology - Paris, 2012, 106 (3-4), pp.58-61. ⟨10.1016/j.jphysparis.2012.01.002⟩. ⟨hal-00850605⟩
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- Luc Estebanez, Sami El Boustani, Alain Destexhe, Daniel Shulz. Correlated input reveals coexisting coding schemes in a sensory cortex.. Nature Neuroscience, 2012, 15 (12), pp.1691-9. ⟨10.1038/nn.3258⟩. ⟨hal-00850571⟩
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2011
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- Julie Le Cam, Luc Estebanez, Vincent Jacob, Daniel Shulz. Spatial structure of multiwhisker receptive fields in the barrel cortex is stimulus dependent.. Journal of Neurophysiology, 2011, 106 (2), pp.986-98. ⟨10.1152/jn.00044.2011⟩. ⟨hal-00635975⟩
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2010
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- Vincent Jacob, Luc Estebanez, Julie Le Cam, Jean-Yves Tiercelin, Patrick Parra, et al.. The Matrix: a new tool for probing the whisker-to-barrel system with natural stimuli.. Journal of Neuroscience Methods, 2010, 189 (1), pp.65-74. ⟨10.1016/j.jneumeth.2010.03.020⟩. ⟨hal-00502608⟩
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Conference papers
2019
- ref_biblio
- Dorian Goueytes, Aamir Abbasi, Henri Lassagne, Daniel Shulz, Luc Estebanez, et al.. Control of a robotic prosthesis simulation by a closed-loop intracortical brain-machine interface. 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), Mar 2019, San Francisco, France. pp.183-186, ⟨10.1109/NER.2019.8716885⟩. ⟨hal-02998804⟩
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2008
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- Luc Estebanez, Julie Le Cam, Vincent Jacob, Daniel Shulz. Generation of complex tactile scenes with a novel stimulator applied to the study of barrel cortex sensory integration.. 6th forum of European Neuroscience, 2008, Geneve, Switzerland. pp.en cours. ⟨hal-00381820⟩
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- Julie Le Cam, Vincent Jacob, Luc Estebanez, Daniel Shulz. Diversity of spatio-temporal receptive fields in the barrel cortex studied with a 25 piezoelectric actuators device.. 6th forum of European Neuroscience, 2008, Geneve, Switzerland. pp.en cours. ⟨hal-00381826⟩
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Poster communications
2021
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- Sophie Hubatz, Luc Estebanez, Fan Yang, Thomas Deneux, Guillaume Hucher, et al.. A sensorimotor task to seek neuronal signatures of tactile sensory prediction in the mouse primary somatosensory cortex. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03324366⟩
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Theses
2011
- ref_biblio
- Luc Estebanez. Characterization of the sensory processings in the barrel cortex of the anaesthetized rat.. Neurobiology. Ecole Normale Supérieure de Paris - ENS Paris, 2011. English. ⟨NNT : ⟩. ⟨tel-00696553⟩
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Preprints, Working Papers, ...
2020
- ref_biblio
- Aamir Abbasi, Luc Estebanez, Dorian Goueytes, Henri Lassagne, D. E Shulz, et al.. Cortical closed-loop brain-machine interface requires biomimetic sensory feedback. 2020. ⟨hal-02998734⟩
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