Group leader : Guy Bouvier

SensoMotion – Motion and Perception

In brief

How does our movement affect sensory processing and perception? As we move, our brain needs to continuously decide if the incoming sensory information was generated by our own actions, or some external change in the environment. The brain must distinguish if a sound or a visual cue has been generated ourself, or triggered by an incoming danger. Thus, to form an accurate representation of the world it is critical that the brain distinguishes between self- and externally-generated sensory stimuli. In other words, what we perceive is not necessarily what we see or hear, as the brain interprets sensory information by using our movement and position in space. Our lab aims at understanding the neuronal circuits and computations underlying sensory processing during self-motion, providing new insights into sensory integration during ethological behavior. To achieve this goal, we use cutting edge approaches that combines neuronal tracing, optogenetic manipulations, 2-photon imaging (calcium and voltage) and extracellular high-density silicon probe recordings in awake behaving mice, servo-controlled head motion, eye tracking, and theorical analysis.

RESEARCH

In progress.

MEMBERS

Team leader

Guy Bouvier, Research Scientist
Sensomotion

PUBLICATIONS

2022

Reply to Piochon et al.: NMDARs in Purkinje cells are not involved in parallel fiber-Purkinje cell synaptic plasticity or motor learning. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Schonewille M, Girasole AE, De Zeeuw CI, Bouvier G. PMID 35193965; DOI: 10.1073/pnas.2120480119

2021

NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning. Proc Natl Acad Sci U S A. 2021 09 14; 118(37). Schonewille M, Girasole AE, Rostaing P, Mailhes-Hamon C, Ayon A, Nelson AB, Triller A, Casado M, De Zeeuw CI, Bouvier G. PMID 34507990; DOI: 10.1073/pnas.2102635118

2020

Head Movements Control the Activity of Primary Visual Cortex in a Luminance-Dependent Manner. Neuron. 2020 11 11; 108(3):500-511.e5. Bouvier G, Senzai Y, Scanziani M. PMID 32783882; DOI: 10.1016/j.neuron.2020.07.004
Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning. Nat Neurosci. 2020 07; 23(7):892-902. Cho KKA, Davidson TJ, Bouvier G, Marshall JD, Schnitzer MJ, Sohal VS. PMID 32451483; DOI: 10.1038/s41593-020-0647-1

2018

Cerebellar learning using perturbations. Elife. 2018 11 12; 7. Bouvier G, Aljadeff J, Clopath C, Bimbard C, Ranft J, Blot A, Nadal JP, Brunel N, Hakim V, Barbour B. PMID 30418871; DOI: 10.7554/eLife.31599
Towards resolving the presynaptic NMDA receptor debate. Curr Opin Neurobiol. 2018 08; 51:1-7. Bouvier G, Larsen RS, Rodríguez-Moreno A, Paulsen O, Sjöström PJ. PMID 29454833; DOI: 10.1016/j.conb.2017.12.020

2016

Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron. 2016 Oct 19; 92(2):435-448. de Frutos CA, Bouvier G, Arai Y, Thion MS, Lokmane L, Keita M, Garcia-Dominguez M, Charnay P, Hirata T, Riethmacher D, Grove EA, Tissir F, Casado M, Pierani A, Garel S. PMID 27693257; DOI: 10.1016/j.neuron.2016.09.020
Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. Cell Rep. 2016 Apr 05; 15(1):104-116. Bouvier G, Higgins D, Spolidoro M, Carrel D, Mathieu B, Léna C, Dieudonné S, Barbour B, Brunel N, Casado M. PMID 27052175; DOI: 10.1016/j.celrep.2016.03.004
Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. J Physiol. 2016 Feb 15; 594(4):915-36. Ly R, Bouvier G, Szapiro G, Prosser HM, Randall AD, Kano M, Sakimura K, Isope P, Barbour B, Feltz A. PMID 26627919; DOI: 10.1113/JP271623

2015

Presynaptic NMDA receptors: Roles and rules. Neuroscience. 2015 Dec 17; 311:322-40. Bouvier G, Bidoret C, Casado M, Paoletti P. PMID 26597763; DOI: 10.1016/j.neuroscience.2015.10.033
Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. J Neurosci. 2015 Aug 19; 35(33):11482-99. Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ. PMID 26290228; DOI: 10.1523/JNEUROSCI.3655-14.2015
Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons. Front Synaptic Neurosci. 2015; 7:1. Bidoret C, Bouvier G, Ayon A, Szapiro G, Casado M. PMID 25750623; DOI: 10.3389/fnsyn.2015.00001

2013

T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20302-7. Ly R, Bouvier G, Schonewille M, Arabo A, Rondi-Reig L, Léna C, Casado M, De Zeeuw CI, Feltz A. PMID 24277825; DOI: 10.1073/pnas.1311686110
Persistent posttetanic depression at cerebellar parallel fiber to Purkinje cell synapses. PLoS One. 2013; 8(7):e70277. Bergerot A, Rigby M, Bouvier G, Marcaggi P. PMID 23922966; DOI: 10.1371/journal.pone.0070277