Group leader: Thierry Bal

Homeostasis, Perception and States (HOPES)

In brief

Sensory perception, selective attention or perceptual awareness are intimately linked to the states of neuronal assemblies during wake and sleep; presumably depending on the level, frequencies and localizations of synchronized/de-synchonized activities, and may rely for their establishment and maintenance on plasticity homeostasis at various scales, from the synapse to the system. We study selected questions concerning these broad issues, by bringing together neurophysiologists with expertise on a large variety of techniques applied at scales ranging from the single synapse to dendrites, cells and systems, in vitro and in vivo.

The emphasis is on cortical structures (visual, entorhinal, insular); their various states of activity (oscillations vs asynchronous irregular states); their link to cognitive functions, with emphasis on visual perception, including their relationships with the claustrum (a thin structure reciprocally and topographically connecting all cortical areas, and hypothesized to amplify or adjust their level of excitability or of oscillations). Computational modeling, via daily basis collaboration with other ICN teams, is combined with our experimental studies.

In the initial stage of visual perception, visual information collected at the retina, flows through the thalamus to the primary visual cortical area (V1) where it interacts with horizontal inputs intrinsic to V1, feedback inputs coming from higher-order brain areas, and sub-cortical inputs such as from the claustrum or modulatory inputs which are known to regulate brain states. The aim of our work carried in vivo in higher mammals (cat and marmoset) is to better understand how visual information is processed through the interplay between feed-forward and feedback visual cortical areas both in the absence of attention-related processes (i.e. under anesthesia) but also in the awake attentive brain. It is also to explore the still largely unknown role of cortico-claustral reciprocal connections, which could be involved in attention, salience detection or state-dependant oscillation regulation.

Our approaches in vitro in thalamic and cortical brain slices, and in cell culture, are complementary to the in vivo and modeling explorations of neuronal networks and synaptic plasticity, in various sensory systems and brain states in the department of Integrative and Computational Neuroscience. Our recent findings range from demonstrating homeostatic synaptic plasticity in vertebrates preparations, to testing theories on the cellular mechanisms of attention using artificial conductance injection in biological neurons. Our goal is to explore the excitability and state-dependent dynamics of thalamic and cortical neurons and circuits, and more recently the claustrum, from the synapse and dendritic branches, up to the whole network.
The originality is the use of “active networks” in brain slices, in which neurons are examined within a more natural synaptically active environment that mimics sleep-wake states and their transitions. We have used and pioneered novel strategies to monitor the magnetic field produced by biological cells, and the voltage in axon and dendrites of individual neurons with high spatial and temporal resolution.

Latest in vitro results

We proposed a mechanism for selective attention in thalamic neurons using a neuron-machine interface (dynamic-clamp). (Behuret et al., Frontiers in Neural Circuits, 2015; Behuret et al., PLoS Comput. Biol., 2013, collaboration with Y. Frégnac).

First demonstration in vertebrate of synaptic homeostasis of the neuromuscular transmission (Ouanounou et al., eLife, 2016).

Magnetrodes: First demonstration of magnetic field recording in biological cells using the Giant Magneto Resistance effect (GMR). Collaboration with the CEA. (Barbieri et al., Scientific Report, 2016).

We tested the theory that extracellular medium around neurons has non-ohmic properties (which may impact on the understanding of extracellular recordings such as EEG or LFP). (Gomes et al., Biophys. J., 2016, collaboration with A. Destexhe).

We used voltage sensitive dye imaging (VSD) to probe dendritic and axonal activities in neurons, and we installed the technique in NeuroPSI. (Casale et al;, J. Neuroscience, 2015)

Latest in vivo results

We propose that long-range horizontal synaptic connections in the primary visual cortex constitute the neural correlate of a perceptual bias in speed detection. (Gerard-Mercier et al. , J. Neuroscience, 2016)

We demonstrate the hidden complexity behind the Simple or Complex nature of receptive fields in the primary visual cortex that relies on the imbalance between the weights of the Simple-like and Complex-like synaptic contributions. (Fournier et al., J. Neuroscience, 2014)

The functional properties of the primary visual cortex network, as measured from the receptive field estimates, are not fixed, but instead adapt to the statistical properties of the visual input. (Fournier et al., Nature Neuroscience, 2011)

Selected publications

  • Gilles Ouanounou, Baux Gérard and Thierry Bal, A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission, eLife 5: (2016) DOI: 10.7554/eLife.12190
  • Florian Gerard-Mercier, Pedro Carelli, Marc Pananceau, Xoana Troncoso and Yves Frégnac, Synaptic Correlates of Low-Level Perception in V1, Journal of Neuroscience 36 : 3925–3942, (2016) DOI: 10.1523/JNEUROSCI.4492-15.2016
  • Sébastien Béhuret, Charlotte Deleuze and Thierry Bal, Corticothalamic Synaptic Noise as a Mechanism for Selective Attention in Thalamic Neurons, Frontiers in Neural Circuits 9 : 11633, (2015) DOI: 10.3389/fncir.2015.00080
  • Amanda Casale, Amanda Foust, Thierry Bal and David A. McCormick, Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties, Journal of Neuroscience 35 : 15555, (2015) DOI: 10.1523/JNEUROSCI.1467-13.2015
  • Fournier, J., Monier, C., Levy, M., Marre, O., Sári, K., Kisvárday, Z. F., & Frégnac, Y. (2014). Hidden complexity of synaptic receptive fields in cat V1. The Journal of Neuroscience, 34(16), 5515–5528. DOI: 10.1523/JNEUROSCI.0474-13.2014
  • Fournier, J., Monier, C., Pananceau, M., & Frégnac, Y. (2011). Adaptation of the simple or complex nature of V1 receptive fields to visual statistics. Nature Neuroscience, 14(8), 1053–1060. DOI: 10.1038/nn.2861
  • Jakob Wolfart, Damien Debay, Gwendal Le Masson, Alain Destexhe and Thierry Bal, Synaptic background activity controls spike transfer from thalamus to cortex, Nat Neurosci 8 : 1760-7, (2005) DOI: 10.1038/nn1591
  • Gwendal Le Masson, Sylvie Renaud-Le Masson, Damien Debay and Thierry Bal, Feedback inhibition controls spike transfer in hybrid thalamic circuits, Nature 417 : 854-8, (2002) DOI: 10.1038/nature00825
Peer-reviewed Articles

2020

  • Trang-Anh E Nghiem, Núria Tort-Colet, Tomasz Górski, Ulisse Ferrari, Shayan Moghimyfiroozabad, Jennifer S Goldman, Bartosz Teleńczuk, Cristiano Capone, Thierry Bal, Matteo di Volo, Alain Destexhe. Cholinergic Switch between Two Types of Slow Waves in Cerebral Cortex. Cereb. Cortex, 30, 3451–3466. (2020)

2017

  • Tomasz Gorski, R Veltz, M Galtier, Hélissande Fragnaud and Bartosz Telenczuk, Inverse correlation processing by neurons with active dendrites, bioRxiv (2017)
  • Claude Bedard, Jean-Marie Gomes, Thierry Bal, Alain Destexhe. A framework to reconcile frequency scaling measurements, from intracellular recordings, local-field potentials, up to EEG and MEG signals. J Integr Neurosci. ;16(1):3-18. Review. (2017)

2016

  • V Vilmont, B Cadot, Gilles Ouanounou and ER Gomes, A system for studying mechanisms of neuromuscular junction development and maintenance. Development 143 : 2464-77, (2016)
  • Gilles Ouanounou, Baux Gérard and Thierry Bal, A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission, eLife 5 : , (2016)
  • Jean-Marie Gomes, Claude Bedard, Silvana Valtcheva, Matthew Nelson, Vitalia Khokhlova, Pierre Pouget, Laurent Venance, Thierry Bal and Alain Destexhe, Intracellular Impedance Measurements Reveal Non-ohmic Properties of the Extracellular Medium around Neurons, Biophysical Journal 110 : 234-246, (2016)
  • Yann Zerlaut, Bartosz Telenczuk, Charlotte Deleuze, Thierry Bal, Gilles Ouanounou and Alain Destexhe, Heterogeneous firing rate response of mouse layer V pyramidal neurons in the fluctuation-driven regime, The Journal of Physiology 594 : 3791-3808, (2016)
  • Francesca Barbieri, Vincent Trauchessec, Laure Caruso, Josué Trejo-Rosillo, Bartosz Telenczuk, Elodie Paul, Thierry Bal, Alain Destexhe, Claude Fermon, Myriam Pannetier-Lecoeur and Gilles Ouanounou, Local recording of biological magnetic fields using Giant Magneto Resistance-based microprobes, Scientific Reports 6 : Article number : 39330, (2016)

2015

  • R Araoz, Gilles Ouanounou, BI Iorga, A Goudet, D Alili, M Amar, E Benoit, J Molgo and D Servent, The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors., Toxicol Sci 147 : 156-67, (2015)
  • Amanda Casale, Amanda Foust, Thierry Bal and David A. McCormick, Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties, Journal of Neuroscience 35 : 15555, (2015)
  • Sébastien Béhuret, Charlotte Deleuze and Thierry Bal, Corticothalamic Synaptic Noise as a Mechanism for Selective Attention in Thalamic Neurons, Frontiers in Neural Circuits 9 : 11633, (2015)

2014

  • J.F Gomez-Gonzalez, Alain Destexhe and Thierry Bal, Application of Active Electrode Compensation to Perform Continuous Voltage-Clamp Recordings with Sharp Microelectrodes, Journal of Neural Engineering 11 : 056028, (2014)

2013

  • Sébastien Béhuret, Charlotte Deleuze, Leonel Gomez-Sena, Yves Frégnac and Thierry Bal, Cortically-Controlled Population Stochastic Facilitation as a Plausible Substrate for Guiding Sensory Transfer across the Thalamic Gateway, PLOS Computational biology, 2013, PLOS computational biology 9 : e1003401, (2013)

2012

  • Claude Bedard, Sébastien Béhuret, Charlotte Deleuze, Thierry Bal and Alain Destexhe, Oversampling method to extract excitatory and inhibitory conductances from single-trial membrane potential recordings. , Journal of Neuroscience Methods : , (2012)
  • Charlotte Deleuze, D Francois, Sébastien Béhuret, Gérard Sadoc, Hee-Sup Shin, Victor N. Uebele, John J. Renger, Régis C. Lambert, Nathalie Leresche and Thierry Bal, T-Type Calcium Channels Consolidate Tonic Action Potential Output of Thalamic Neurons to Neocortex, Journal of Neuroscience 32 (35) : 12228–12236, (2012)

2011

  • B Rouzaire-Dubois, Gilles Ouanounou and JM Dubois, Relationship between extracellular osmolarity, NaCl concentration and cell volume in rat glioma cells., Gen Physiol Biophys 30 : 162-6, (2011)
  • Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe, Comparison of different neuron models to conductancebased post-stimulus time histograms obtained in cortical pyramidal cells using dynamic-clamp in vitro, Biological Cybernetics 105(2) : 167-180, (2011)
  • A Tscherter, François David, T Ivanova, Charlotte Deleuze, John J. Renger, Victor N. Uebele, Thierry Bal, Nathalie Leresche and Régis C. Lambert, Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics, J Physiol (London) 589 : 1707-1724, (2011)

2010

  • S Schlumberger, Gilles Ouanounou, E Girard, M Sasaki, H Fuwa, MC Louzao, LM Botana, E Benoit and J Molgo, The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells., Toxicon 56 : 785-91, (2010)

2009

  • B Rouzaire-Dubois, Gilles Ouanounou, S O’Regan and JM Dubois, Sodium-dependent activity of aquaporin-1 in rat glioma cells : a new mechanism of cell volume regulation., Pflugers Arch 457 : 1187-98, (2009)
  • JM Dubois, Gilles Ouanounou and B Rouzaire-Dubois, The Boltzmann equation in molecular biology., Prog Biophys Mol Biol 99 : 87-93, (2009)
  • Sami El Boustani, Olivier Marre, Sébastien Béhuret, Pierre Baudot, Pierre Yger, Thierry Bal, Alain Destexhe and Yves Frégnac, Network-state modulation of power-law frequency-scaling in visual cortical neurons, PLoS Computational Biology 5: : e10005519, (2009)
  • Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe, Extracting synaptic conductances from single membrane potential traces, Neuroscience 158 : 545-552, (2009)
  • Martin Pospischil, Zuzanna Piwkowska, Thierry Bal and Alain Destexhe, Characterizing neuronal activity by describing the membrane potential as a stochastic process, Journal of Physiology > Paris 103 : 98-106, (2009)

2008

  • Barbara Beyer, Charlotte Deleuze, Verity A. Letts, Connie L. Mahaffey, Rebecca M. Boumil, Timothy A. Lew, John R. Huguenard and Wayne N. Frankel, Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4, Hum Mol Genet 17 : 1738-1749, (2008)
  • Martin Pospischil, Maria Toledo-Rodriguez, Cyril Monier, Zuzanna Piwkowska, Thierry Bal, Yves Frégnac, Henry Markram and Alain Destexhe, Minimal Hodgkin–Huxley type models for different classes of cortical and thalamic neurons, Biological Cybernetics 99 : 427-441, (2008)
  • Romain Brette, Zuzanna Piwkowska, Cyril Monier, Michelle Rudolph, Julien Fournier, Manuel Levy, Yves Frégnac, Thierry Bal and Alain Destexhe, High-Resolution Intracellular Recordings Using a Real-Time Computational Model of the Electrode, Neuron 59 : 379-391, (2008)
  • R Kharrat, D Servent, E Girard, Gilles Ouanounou, M Amar, R Marrouchi, E Benoit and J Molgo, The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity., J Neurochem 107 : 952-63, (2008)

2007

  • Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe, Calculating event-triggered average synaptic conductances from the membrane potential, J Neurophysiol 97 : 2544-52, (2007)
  • Zuzanna Piwkowska, Martin Pospischil, Romain Brette, Julia Sliwa, Michelle Rudolph, Thierry Bal and Alain Destexhe, Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation, Journal of Neuroscience Methods 169 : 302-322, (2007)
  • Martin Pospischil, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe, Inhibitory conductance dynamics in cortical neurons during activated states, Neurocomputing 70 : 1602-1604, (2007)
  • Romain Brette, Zuzanna Piwkowska, Michelle Rudolph, Thierry Bal and Alain Destexhe, A nonparametric electrode model for intracellular recording, Neurocomputing 70 : 1597-1601, (2007)

2006

  • Mathilde Badoual, Quan Zou, Andrew Davison, Michelle Rudolph, Thierry Bal, Yves Frégnac and Alain Destexhe, Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity, Int J Neural Syst 16 : 79-97, (2006)
  • Charlotte Deleuze and John R. Huguenard, Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus : potential roles in synchronization and sensation, J Neurosci 26 : 8633-45, (2006)

2005

  • Charlotte Deleuze, M Runquist, H Orcel, A Rabie, G Dayanithi, G Alonso and Nicolas Hussy, Structural difference between heteromeric somatic and homomeric axonal glycine receptors in the hypothalamo-neurohypophysial system, Neuroscience 135 : 475-83, (2005)
  • Mathilde Badoual, Michelle Rudolph, Zuzanna Piwkowska, Alain Destexhe and Thierry Bal, High discharge variability in neurons driven by current noise, Neurocomputing 65 : 493-498, (2005)
  • Jakob Wolfart, Damien Debay, Gwendal Le Masson, Alain Destexhe and Thierry Bal, Synaptic background activity controls spike transfer from thalamus to cortex, Nat Neurosci 8 : 1760-7, (2005)
  • JP Mothet, L Pollegioni, Gilles Ouanounou, M Martineau, Philippe Fossier and Gérard Baux, Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine, PNAS 102 : 5606-11, (2005)
  • Charlotte Deleuze, G Alonso, IA Lefevre, Anne Duvoid-Guillou and Nicolas Hussy, Extrasynaptic localization of glycine receptors in the rat supraoptic nucleus : further evidence for their involvement in glia-to-neuron communication, Neuroscience 133 : 175-83, (2005)

2004

  • Leonel Gomez, Morten Kanneworff and Ruben Budelli, Dendritic spike back propagation in the electrosensory lobe of Gnathonemus petersii, Journal of experimental biology 208 : 141-155, (2004)
  • Leonel Gomez, Ruben Budelli and Angel A. Caputi, Pre-receptor profile of sensory images and primary afferent neuronal representation in the mormyrid electrosensory system, The journal of experimental biology 207 : 2444-2453, (2004)
  • Zuzanna Piwkowska, Michelle Rudolph, Mathilde Badoual, Alain Destexhe and Thierry Bal, Re-creating active states in vitro with a dynamic-clamp protocol, Neurocomputing : 55-60, (2004)
  • Yves Frégnac and Thierry Bal, From neuronal assemblies to cyborgs, Journal of Physiology > Paris 98 : 293-295, (2004)
  • Damien Debay, Jakob Wolfart, Yann Le Franc, Gwendal Le Masson and Thierry Bal, Exploring spike transfer through the thalamus using hybrid artificial-biological neuronal networks, J Physiol Paris 98 : 540-58, (2004)
  • Michelle Rudolph, Zuzanna Piwkowska, Mathilde Badoual, Thierry Bal and Alain Destexhe, A method to estimate synaptic conductances from membrane potential fluctuations, J Neurophysiol 91 : 2884-96, (2004)
  • Alain Destexhe, Mathilde Badoual, Zuzanna Piwkowska, Thierry Bal and Michelle Rudolph, A novel method for characterizing synaptic noise in cortical neurons, Neurocomputing 58 : 191-196, (2004)
  • Ludovic Alvado, Jean Tomas, Sylvain Saïghi, Sylvie Renaud, Thierry Bal, Alain Destexhe and Gwendal Le Masson, Hardware computation of conductance-based neuron models, Neurocomputing 58 : 109-115, (2004)

2003

  • Yousheng Shu, Andrea Hasenstaub, Mathilde Badoual, Thierry Bal and David A. McCormick, Barrages of synaptic activity control the gain and sensitivity of cortical neurons, J Neurosci 23 : 10388-401, (2003)
  • David A. McCormick, Yousheng Shu, Andrea Hasenstaub, Maria V Sanchez-Vives, Mathilde Badoual and Thierry Bal, Persistent cortical activity : mechanisms of generation and effects on neuronal excitability, Cereb Cortex 13 : 1219-31, (2003)

2002

  • Gilles Ouanounou, M Malo, J Stinnakre, AS Kreger and J Molgo, Trachynilysin, a neurosecretory protein isolated from stonefish (Synanceia trachynis) venom, forms nonselective pores in the membrane of NG108-15 cells., J Biol Chem 277 : 39119-27, (2002)
  • Gwendal Le Masson, Sylvie Renaud-Le Masson, Damien Debay and Thierry Bal, Feedback inhibition controls spike transfer in hybrid thalamic circuits, Nature 417 : 854-8, (2002)
  • E Benoit, C Mattei, Gilles Ouanounou, FA Meunier, D Suput, F Le Gall, M Marquais, MY Dechraoui and J Molgo, Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins, Cell Mol Biol Lett. 7 : 317-21, (2002)

2001

  • Damien Debay, Alain Destexhe and Thierry Bal, Corticothalamic feedback can induce hypersynchronous low-frequency rhythms in the physiologically intact thalamus, Neurocomputing 38 : 529-538, (2001)

2000

  • Nicolas Hussy, Charlotte Deleuze, Michel G. Desarmenien and Françoise C. Moos, Osmotic regulation of neuronal activity : a new role for taurine and glial cells in a hypothalamic neuroendocrine structure, Prog Neurobiol 62 : 113-34, (2000)
  • Nicolas Hussy, Charlotte Deleuze, V Bres and Françoise C. Moos, New role of taurine as an osmomediator between glial cells and neurons in the rat supraoptic nucleus, Adv Exp Med Biol 483 : 227-37, (2000)
  • Charlotte Deleuze, Anne Duvoid, Françoise C. Moos and Nicolas Hussy, Tyrosine phosphorylation modulates the osmosensitivity of volume-dependent taurine efflux from glial cells in the rat supraoptic nucleus, J Physiol 523 Pt 2 : 291-9, (2000)
  • Thierry Bal, Damien Debay and Alain Destexhe, Cortical feedback controls the frequency and synchrony of oscillations in the visual thalamus, J Neurosci 20 : 7478-88, (2000)
  • FA Meunier, R Frangez, E Benoit, Gilles Ouanounou, B Rouzaire-Dubois, D Suput and J Molgo, Ca(2+) and Na(+) contribute to the swelling of differentiated neuroblastoma cells induced by equinatoxin-II., Toxicon 38 : 1547-60, (2000)

1999

  • Gwendal Le Masson, A Laflaquiere, Thierry Bal and Gwendal Le Masson, Analog circuits for modeling biological neural networks : design and applications, IEEE Trans Biomed Eng 46 : 638-45, (1999)

1998

  • Charlotte Deleuze, Anne Duvoid and Nicolas Hussy, Properties and glial origin of osmotic-dependent release of taurine from the rat supraoptic nucleus, J Physiol 507 ( Pt 2) : 463-71, (1998)
  • Anita Luthi, Thierry Bal and David A. McCormick, Periodicity of thalamic spindle waves is abolished by ZD7288,a blocker of Ih, J Neurophysiol 79 : 3284-9, (1998)

1997

  • Nicolas Hussy, Charlotte Deleuze, A Pantaloni, Michel G. Desarmenien and Françoise C. Moos, Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones : possible role in osmoregulation, J Physiol 502 ( Pt 3) : 609-21, (1997)
  • David A. McCormick and Thierry Bal, Sleep and arousal : thalamocortical mechanisms, Annu Rev Neurosci 20 : 185-215, (1997)
  • Maria V Sanchez-Vives, Thierry Bal and David A. McCormick, Inhibitory interactions between perigeniculate GABAergic neurons, J Neurosci 17 : 8894-908, (1997)
  • Thierry Bal and David A. McCormick, Synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current I(h), J Neurophysiol 77 : 3145-56, (1997)

1996

  • Maria V Sanchez-Vives, Thierry Bal, Uhnoh Kim, Marcus von Krosigk and David A. McCormick, Are the interlaminar zones of the ferret dorsal lateral geniculate nucleus actually part of the perigeniculate nucleus ?, J Neurosci 16 : 5923-41, (1996)
  • Alain Destexhe, Thierry Bal, David A. McCormick and Terrence J. Sejnowski, Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices, J Neurophysiol 76 : 2049-70, (1996)
  • Thierry Bal and David A. McCormick, What stops synchronized thalamocortical oscillations ?, Neuron 17 : 297-308, (1996)

1995

  • Thierry Bal, Marcus von Krosigk and David A. McCormick, Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro, J Physiol 483 ( Pt 3) : 641-63, (1995)
  • Uhnoh Kim, Thierry Bal and David A. McCormick, Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro, J Neurophysiol 74 : 1301-23, (1995)
  • Thierry Bal, Marcus von Krosigk and David A. McCormick, Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro, J Physiol 483 ( Pt 3) : 665-85, (1995)

1994

  • Thierry Bal, Frédéric Nagy and Maurice Moulins, Muscarinic modulation of a pattern-generating network : control of neuronal properties, J Neurosci 14 : 3019-35, (1994)
  • David A. McCormick and Thierry Bal, Sensory gating mechanisms of the thalamus, Curr Opin Neurobiol 4 : 550-6, (1994)

1993

  • Thierry Bal and David A. McCormick, Mechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro : a mammalian pacemaker, J Physiol 468 : 669-91, (1993)
  • Marcus von Krosigk, Thierry Bal and David A. McCormick, Cellular mechanisms of a synchronized oscillation in the thalamus, Science 261 : 361-4, (1993)

1988

  • Thierry Bal, Frédéric Nagy and Maurice Moulins, The pyloric pattern generator in crustacea : a set of conditional neuronal oscillators,
    J. Comp. Physiol. A, : 715-727 : 163, (1988)

Livres et Thèses

2015

  • Jean-Marie Gomes, Etude expérimentale et théorique de la génèse des potentiels de champs locaux par les neurones corticaux, In : () Thèse , (2015)

2012

  • Sébastien Béhuret, Exploration par des interfaces hybrides du code neuronal et des mecanismes de régulation de l’information sensorielle dans le système visuel, In : () Thèse , (2012)

Chapitres de livre

2009

  • Zuzanna Piwkowska, Martin Pospischil, Michelle Rudolph, Thierry Bal and Alain Destexhe, Testing methods for synaptic conductance analysis using controlled conductance injection with dynamic clamp, In : Dynamic Clamp. From Principles to Applications (A. Destexhe and T. Bal) Springer 115-140, (2009)
  • Zuzanna Piwkowska, Alain Destexhe and Thierry Bal, Associating living cells and computational models : from basics to present applications of the dynamic-clamp, In : Dynamic Clamp. From Principles to Applications (A. Destexhe and T. Bal ) Springer 1-30, (2009)
  • Romain Brette, Zuzanna Piwkowska, Cyril Monier, Jose Gomez, Yves Frégnac, Thierry Bal and Alain Destexhe, Dynamic clamp with high resistance electrodes using active electrode compensation in vitro and in vivo. , In : Dynamic-clamp : From Principles to Applications (Destexhe Alain and Bal Thierry) Springer, new York 347-382, (2009)
  • Gérard Sadoc, Gwendal Le Masson, B Foutry, Alain Destexhe and Thierry Bal, Recreating in-vivo-like activity and investigating the signal transfer capabilities of neurons : dynamic clamp applications using real-time NeuronTM., In : Dynamic clamp : from principles to applications (T. Bal andA. Destexhe ) Springer-Verlag , (2009)

Présentations

2010

  • Charlotte Deleuze, François David, Régis C. Lambert, Nathalie Leresche , Sébastien Béhuret, Alain Destexhe, Hee-Sup Shin, Victor N. Uebele, John J. Renger and Thierry Bal, T-type calcium channels boost the thalamic relay of sensory inputs during cortical-like synaptic background, Poster At : Society for Neuroscience, (San Diego (USA)) (2010)
  • A Tscherter, T Ivanova, François David, Charlotte Deleuze, Thierry Bal, Nathalie Leresche and Régis C. Lambert, Minimal differences in biophysical properties of T-channels drastically affect thalamocortical burst firing pattern, Poster At : Forum of European Neuroscience, (Amsterdam (Holland)) (2010)
  • Gilles Ouanounou, Gérard Baux and Thierry Bal, What makes the homeostasis of signal transmission at the neuromuscular synapse ?, Poster At : 7th Forum of European Neuroscience, (Amsterdam (Holland)) (2010)
  • Sébastien Béhuret, Leonel Gomez, Yves Frégnac and Thierry Bal, Context-dependent information transfer in model thalamocortical circuits, Poster At : NEUROBIOLOGY CONFERENCES LADISLAV TAUC , (Gif sur Yvette (France)) (2010)
  • Sébastien Béhuret, Leonel Gomez, Yves Frégnac and Thierry Bal, Context-dependency in the transfer of sensoryt information transfer in thalamo-cortico-thalamical circuits, Poster At : 7th Forum of European Neuroscience, (Amsterdam (Holland)) (2010)
  • Thierry Bal, Charlotte Deleuze, Sébastien Béhuret, Jose Gomez, Nathalie Leresche and Régis C. Lambert, Replaying thalamocortical interactions via artificial conductance injections in biological neurons., Talk invité At : 7th Forum of European Neuroscience, (Amsterdam) (2010)
  • Charlotte Deleuze, François David, Régis C. Lambert, Nathalie Leresche , Sébastien Béhuret, Hee-Sup Shin and Thierry Bal, T-type calcium channels boost the thalamic relay of sensory inputs during cortical-like synaptic background., Poster At : 7th Forum of European Neuroscience, (Amsterdam (Holland)) (2010)
  • Sébastien Béhuret, Leonel Gomez, Yves Frégnac and Thierry Bal, Context-dependent information transfer in model thalamocortical circuits, Poster At : FACETS, (Paris (France)) (2010)

2009

  • Thierry Bal, Sébastien Béhuret, Charlotte Deleuze, Leonel Gomez, Zuzanna Piwkowska, Jakob Wolfart, Damien Debay, Romain Brette, Sami El Boustani, Olivier Marre, Pierre Baudot, Pierre Yger, Michelle Rudolph, Gwendal Le Masson, Gérard Sadoc, Alain Destexhe and Yves Frégnac, Hybrid biological-artificial neuronal networks, Poster At : Colloque Interface physique, chimie, biologie, soutient à la prise de risque, (Fréjus (France)) (2009)
  • Thierry Bal, Hybrid biological/artificial neuronal circuits and an introduction to active electrode compensation, Talk invité At : Les Nouvelles Technologies Pour Les Neurosciences / New Technologies For Neurosciences., (Rhône-Alpes (France)) (2009)

2008

  • Romain Brette, Zuzanna Piwkowska, J.F Gomez-Gonzalez, Cyril Monier, Michelle Rudolph, Julien Fournier, Manuel Levy, Yves Frégnac, Thierry Bal and Alain Destexhe, Active Electrode Compensation for high-resolution intracellular recordings in vitro and in vivo, Poster At : Society for Neuroscience Abstracts 34, (Washington DC (USA)) (2008)
  • Thierry Bal, Zuzanna Piwkowska, Romain Brette, Jakob Wolfart, Damien Debay, Cyril Monier, Michelle Rudolph, Julien Fournier, Manuel Levy, Yves Frégnac, Alain Destexhe and Gwendal Le Masson, Thalamocortical hybrid networks and an introduction to Active Electrode Compensation., Talk invité At : Meeting of the Physiological Society, Techniques Workshop, (University of Cambridge) (2008)

2007

  • Thierry Bal, Synaptic “noise” in a model thalamocortical network increases information transfer from sensory input to cortex. , Talk invité At : Neural Coding 2007, 7th international neural coding workshop, (Montevideo (Uruguay)) (2007)
  • Thierry Bal, Modulation des messages sensoriels selon les états de vigilance. Modélisation par des circuits hybrides : neurone biologique + machine. , Talk invité At : Groupes de réflexion « Cerveaux et Machines », (Les Clayes-sous-Bois (France)) (2007)

2006

  • Thierry Bal, The influence of synaptic background activity on the spike transfer from thalamus to cortex, Talk invité At : 29th European Conference on Visual Perception, (St. Petersburg (Russia)) (2006)
  • Thierry Bal, Le neurone cortical dans un réseau actif : développements et applications de techniques d’enregistrements intracellulaires couplées à la modélisation en temps réel., Talk invité At : Journées de l’Ecole Doctorale “Cerveau Cognition Comportement, (Roscoff (France)) (2006)
  • Thierry Bal, Spike transfer properties of thalamic neurons in ‘hybrid neurons ‘ in vitro, Talk invité At : . Latsis symposium “Dynamical principles for neuroscience and intelligent biomimetic devices, (Lausanne (Switzerland)) (2006)