The research conducted in Alain Destexhe’s laboratory stands at the interface between several disciplines, such as biophysics, physics, computer science and neuroscience. The themes investigated range from the microscopic (single neurons) to the macroscopic (networks or populations of neurons) aspects of the central nervous system function. At the single cell level, we use theoretical methods and computer-based simulation techniques to explore the complex behavior of cortical and thalamic neurons and understand their integrative properties. At the network level, we try to understand the collective behavior of neuronal populations, and how information is processed and represented. We also study the genesis of sleep rhythms, their physiological role and their perversion into pathological rhythms such as epileptic seizures.