Équipe Catherine Del Negro, Jean-Marc Edeline
Code neuronal & perception auditive
En bref
Nos recherches visent à comprendre le code neural impliqué dans le traitement des signaux de communication. Chez l’oiseau, nos résultats montrent que les neurones d’une région auditive de haut niveau sont sensibles à l’ordre séquentiel des éléments du chant. Chez les mammifères, la robustesse aux dégradations acoustiques des réponses neuronales s’observe à chaque niveau du système auditif. Les stratégies de codage mises en jeu dans les implants cochléaires, et le rôle de l’ocytocine dans la modulation de la réponse corticale aux sons de la communication, sont également étudiés.

Deux modèles animaux sont utilisés dans notre équipe. D’une part, chez le cobaye nous étudions comment l’organisation temporelle des trains de potentiel d’action génère un code permettant la discrimination entre vocalisations au sein du système auditif thalamo-cortical. D’autre part, chez des oiseaux chanteurs (le canari et le diamant mandarin) dont les vocalisations présentent un certain nombre de points communs avec le langage humain, nous étudions les propriétés des neurones d’une structure sensori-motrice (le HVC) qui répondent préférentiellement à la présentation du propre chant de l’oiseau. Nous cherchons également à savoir si la mémorisation des vocalisations d’individus devenus familiers s’accompagne de changements dans le codage de ces vocalisations au niveau des aires auditives.
Nos axes de recherche les plus récents concernent l’impact d’une surdité partielle induite par traumas acoustiques sur le codage de stimuli naturels tels que des vocalisations conspécifiques. Notre hypothèse est que des pertes auditives mêmes minimes, ne provoquant pas de diminution des réponses neuronales en termes de taux de décharge, provoqueraient une désorganisation des patterns temporels de décharge.
Publications choisies
- Souffi S, Varnet L, Zaidi M, Bathellier B, Huetz C, Edeline JM (in press) Reduction in sound discrimination in noise is related to envelope similarity and not to a decrease in envelope tracking abilities. Journal of Physiology (London) DOI: 10.1113/JP283526
- Partouche E, Adenis V, Gnansia D, Stahl P, & Edeline J-M (2022) Increased threshold and reduced firing rate of auditory cortex neurons after cochlear implant insertion. Brain Sciences, 12(2) 205. DOI: 10.3390/brainsci12020205
- Rolland M, Del Negro C, Giret N. (2022) Multisensory processes in birds: From single neurons to the influence of social interactions and sensory loss. Neurosci Biobehav Rev. 143:104942. DOI: 10.1016/j.neubiorev.2022.104942
- Cazala A, Del Negro C, Giret N. (2021) Distinct timescales for the neuronal encoding of vocal signals in a high-order auditory area. Sci Rep. 11(1):19672. DOI: 10.1038/s41598-021-99135-w
- Royer J, Occelli F, Huetz C, Cancela JM & Edeline J-M (2021) Enhanced discriminative abilities of auditory cortex neurons for pup calls despite reduced evoked responses in C57BL/6 mother mice. Neuroscience. 453:1-16. DOI: 10.1016/j.neuroscience.2020.11.031
- Souffi S, Lorenzi C, Huetz C & Edeline JM (2021) Robustness to noise in the auditory system: A distributed and predictable property eNeuro. Mar 18; 8(2):ENEURO.0043-21.2021. DOI: 10.1523/ENEURO.0043-21.2021
- Souffi S, Nodal FR, Bajo VM & Edeline JM (2021) When and how does the auditory cortex influence subcortical auditory structures? New insights about the roles of descending cortical projections. Frontiers in Neuroscience 15:690223. DOI: 10.3389/fnins.2021.690223
- Gaucher Q, Yger P & Edeline J-M (2020) Increasing excitation vs. decreasing inhibition in auditory cortex: Consequences on the discrimination performance between communication sounds. Journal of Physiology (London) 598(17):3765-3785. DOI: 10.1113/JP279902
- Zai AT, Cavé-Lopez S, Rolland M, Giret N, Hahnloser RHR. (2020) Sensory substitution reveals a manipulation bias. Nat Commun. 11(1):5940. DOI: 10.1038/s41467-020-19686-w
- Yamahachi H, Zai AT, Tachibana RO, Stepien AE, Rodrigues DI, Cavé-Lopez S, Lorenz C, Arneodo EM, Giret N, Hahnloser RHR. (2020) Undirected singing rate as a non-invasive tool for welfare monitoring in isolated male zebra finches. PLoS One. 2020 Aug 10;15(8):e0236333. DOI: 10.1371/journal.pone.0236333
- Souffi S, Varnet, L, Lorenzi C, Huetz C Edeline JM (2020) Noise-sensitive but more precise subcortical representations co-exist with robust cortical encoding of natural vocalizations. J. Neuroscience. 40(27):5228-5246. DOI: 10.1523/JNEUROSCI.2731-19.2020
- Cazala A. Giret N, Edeline J-M & Del Negro C. (2019) Neuronal encoding in a high level auditory area: from sequential order of elements to grammatical structure, J. Neuroscience. 39(31) 6150-6161. DOI: 10.1523/JNEUROSCI.2767-18.2019
- Adenis V, Gourévitch B, Mamelle E, Recugnat M, Stahl P, Gnansia D, Nguyen Y, Edeline JM. (2018) ECAP growth function to increasing pulse amplitude or pulse duration demonstrates large inter-animal variability that is reflected in auditory cortex of the guinea pig. PLoS One.13(8) e0201771 DOI: 10.1371/journal.pone.0201771
Chefs d’équipe
- Catherine Del Negro, Maitre de Conferences Université Paris Nanterre
Code neuronal & perception auditivebureau 3027
- Souffi S, Varnet L, Zaidi M, Bathellier B, Huetz C, Edeline JM (in press) Reduction in sound discrimination in noise is related to envelope similarity and not to a decrease in envelope tracking abilities. Journal of Physiology (London) DOI: 10.1113/JP283526
- Partouche E, Adenis V, Gnansia D, Stahl P, & Edeline J-M (2022) Increased threshold and reduced firing rate of auditory cortex neurons after cochlear implant insertion. Brain Sciences, 12(2) 205. DOI: 10.3390/brainsci12020205
- Rolland M, Del Negro C, Giret N. (2022) Multisensory processes in birds: From single neurons to the influence of social interactions and sensory loss. Neurosci Biobehav Rev. 143:104942. DOI: 10.1016/j.neubiorev.2022.104942
- Cazala A, Del Negro C, Giret N. (2021) Distinct timescales for the neuronal encoding of vocal signals in a high-order auditory area. Sci Rep. 11(1):19672. DOI: 10.1038/s41598-021-99135-w
- Royer J, Occelli F, Huetz C, Cancela JM & Edeline J-M (2021) Enhanced discriminative abilities of auditory cortex neurons for pup calls despite reduced evoked responses in C57BL/6 mother mice. Neuroscience. 453:1-16. DOI: 10.1016/j.neuroscience.2020.11.031
- Souffi S, Lorenzi C, Huetz C & Edeline JM (2021) Robustness to noise in the auditory system: A distributed and predictable property eNeuro. Mar 18; 8(2):ENEURO.0043-21.2021. DOI: 10.1523/ENEURO.0043-21.2021
- Souffi S, Nodal FR, Bajo VM & Edeline JM (2021) When and how does the auditory cortex influence subcortical auditory structures? New insights about the roles of descending cortical projections. Frontiers in Neuroscience 15:690223. DOI: 10.3389/fnins.2021.690223
- Gaucher Q, Yger P & Edeline J-M (2020) Increasing excitation vs. decreasing inhibition in auditory cortex: Consequences on the discrimination performance between communication sounds. Journal of Physiology (London) 598(17):3765-3785. DOI: 10.1113/JP279902
- Zai AT, Cavé-Lopez S, Rolland M, Giret N, Hahnloser RHR. (2020) Sensory substitution reveals a manipulation bias. Nat Commun. 11(1):5940. DOI: 10.1038/s41467-020-19686-w
- Yamahachi H, Zai AT, Tachibana RO, Stepien AE, Rodrigues DI, Cavé-Lopez S, Lorenz C, Arneodo EM, Giret N, Hahnloser RHR. (2020) Undirected singing rate as a non-invasive tool for welfare monitoring in isolated male zebra finches. PLoS One. 2020 Aug 10;15(8):e0236333. DOI: 10.1371/journal.pone.0236333
- Souffi S, Varnet, L, Lorenzi C, Huetz C Edeline JM (2020) Noise-sensitive but more precise subcortical representations co-exist with robust cortical encoding of natural vocalizations. J. Neuroscience. 40(27):5228-5246. DOI: 10.1523/JNEUROSCI.2731-19.2020
- Cazala A. Giret N, Edeline J-M & Del Negro C. (2019) Neuronal encoding in a high level auditory area: from sequential order of elements to grammatical structure, J. Neuroscience. 39(31) 6150-6161. DOI: 10.1523/JNEUROSCI.2767-18.2019
- Adenis V, Gourévitch B, Mamelle E, Recugnat M, Stahl P, Gnansia D, Nguyen Y, Edeline JM. (2018) ECAP growth function to increasing pulse amplitude or pulse duration demonstrates large inter-animal variability that is reflected in auditory cortex of the guinea pig. PLoS One.13(8) e0201771 DOI: 10.1371/journal.pone.0201771