Institut NeuroPSI - UMR9197
CNRS Université Paris-Saclay
Campus CEA Saclay
Saclay, FRANCE

Dr. Julien Bouvier

Directeur de Recherche
Circuits neuronaux & contrôle moteur

julien.bouvier cnrs.fr
+33(0)1 69 82 34 32, bureau 2021
ORCID : 0000-0002-1307-4426
Twitter : @julbouvier

Research positions

2018-2022: CNRS Research Director (Directeur de Recherche) & Group Leader
Paris-Saclay Institute for Neuroscience, CNRS & University Paris-Saclay,
Saclay, France.

2018-2022: CNRS Researcher (Chargé de Recherches) & Group Leader
Paris-Saclay Institute for Neuroscience, CNRS & University Paris-Saclay,
Gif-Sur-Yvette, France.

2015 – 2018: CNRS Researcher (Chargé de Recherches)
Gilles Fortin’s group. Paris-Saclay Institute for Neuroscience, CNRS & University Paris-Saclay,
Gif-Sur-Yvette, France.

2011 – 2015: EMBO Postdoctoral research fellow
Prof. Ole Kiehn »s group, Department of Neuroscience, Karolinska Institutet Stockholm, Sweden

2005 – 2011: PhD student, Neuroscience, University Paris-11
INAF, CNRS Gif-Sur-Yvette, France. Supervisor: Dr. Gilles Fortin.

Scientific profile

Themes and programs of research:

My research is centered on the neuronal basis of movement, with a particular focus on brainstem and spinal cord circuits that control breathing, locomotion, orientation and posture.

Key approaches and technical skills:

  • Cell-type specific manipulations using straight and conditional viral vectors injected by stereotaxy in the brain or in the spinal cord.
  • Investigation of motor functions in freely-behaving mice using circuit optogenetic and chemogenetic manipulations, calcium imaging, locomotor and respiratory physiology, electromyography and video-tracking.
  • Functional investigations of motor activities on reduced ex vivo preparations: ventral nerve electrophysiological recordings, single cell patch-clamp electrophysiology and calcium-imaging.
  • Neuroanatomy and circuit tracings: conventional and viral-based anterograde, retrograde and trans-synaptic tracing schemes.
  • Microscopy: epifluorescence, confocal and light-sheet microscopes, 3D reconstructions.

Selected communications

Publications

See my Pubmed Library or my ORCID account: ORCID iD iconorcid.org/0000-0002-1307-4426

Article dans une revue

2023

ref_biblio
Coralie Hérent, Séverine Diem, Giovanni Usseglio, Gilles Fortin, Julien Bouvier. Upregulation of breathing rate during running exercise by central locomotor circuits in mice. Nature Communications, 2023, 14 (1), pp.2939. ⟨10.1038/s41467-023-38583-6⟩. ⟨hal-04106925⟩
Accès au texte intégral et bibtex
https://hal.science/hal-04106925/file/Nat-Commuications-41467_2023_article_38583.pdf BibTex

2020

ref_biblio
Coralie Hérent, Séverine Diem, Gilles Fortin, Julien Bouvier. Absent phasing of respiratory and locomotor rhythms in running mice. eLife, 2020, 9, pp.e61919. ⟨10.7554/eLife.61919⟩. ⟨hal-03046134⟩
Accès au texte intégral et bibtex
https://hal.science/hal-03046134/file/absent-phasing-respiratory-locomotor-C-Herent-et-al-elife2020.pdf BibTex
ref_biblio
Joanna Schwenkgrub, Evan Harrell, Brice Bathellier, Julien Bouvier. Deep imaging in the brainstem reveals functional heterogeneity in V2a neurons controlling locomotion. Science Advances , 2020, 6 (49), pp.eabc6309. ⟨10.1126/sciadv.abc6309⟩. ⟨hal-03043145⟩
Accès au texte intégral et bibtex
https://hal.science/hal-03043145/file/eabc6309.full.pdf BibTex
ref_biblio
Sophie Skarlatou, Coralie Hérent, Elisa Toscano, César Mendes, Julien Bouvier, et al.. Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection. Cell Reports, 2020, 31 (10), pp.107741. ⟨10.1016/j.celrep.2020.107741⟩. ⟨hal-02913097⟩
Accès au texte intégral et bibtex
https://hal.science/hal-02913097/file/afadin-signaling-spinal-neuroepithelium-S-Skarlatou-et-al-CellRep2020.pdf BibTex
ref_biblio
Giovanni Usseglio, Edwin Gatier, Aurélie Heuzé, Coralie Hérent, Julien Bouvier. Control of Orienting Movements and Locomotion by Projection-Defined Subsets of Brainstem V2a Neurons. Current Biology - CB, 2020, 30 (23), pp.4665-4681. ⟨10.1016/j.cub.2020.09.014⟩. ⟨hal-02957714⟩
Accès au texte intégral et bibtex
https://hal.science/hal-02957714/file/PIIS0960982220313452%282%29.pdf BibTex

2018

ref_biblio
Vittorio Caggiano, Roberto Leiras, Haizea Goñi-Erro, Debora Masini, Carmelo Bellardita, et al.. Midbrain circuits that set locomotor speed and gait selection. Nature, 2018, 553 (7689), pp.455 - 460. ⟨10.1038/nature25448⟩. ⟨hal-01701722⟩
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2017

ref_biblio
Carmelo Bellardita, Vittorio Caggiano, Roberto Leiras, Vanessa Caldeira, Andrea Fuchs, et al.. Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice. eLife, 2017, 6, ⟨10.7554/eLife.23011⟩. ⟨hal-01699515⟩
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ref_biblio
Luis Rodrigo Hernandez-Miranda, Pierre-Louis Ruffault, Julien Bouvier, Andrew J Murray, Marie-Pierre Morin-Surun, et al.. Genetic identification of a hindbrain nucleus essential for innate vocalization.. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (30), pp.8095-8100. ⟨10.1073/pnas.1702893114⟩. ⟨hal-01571791⟩
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ref_biblio
Jinjin Wu, Paolo Capelli, Julien Bouvier, Martyn Goulding, Silvia Arber, et al.. A V0 core neuronal circuit for inspiration. Nature Communications, 2017, 8 (1), pp.544. ⟨10.1038/s41467-017-00589-2⟩. ⟨hal-02394521⟩
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2015

ref_biblio
Julien Bouvier, Vittorio Caggiano, Roberto Leiras, Vanessa Caldeira, Carmelo Bellardita, et al.. Descending Command Neurons in the Brainstem that Halt Locomotion.. Cell, 2015, 163 (5), pp.1191-203. ⟨10.1016/j.cell.2015.10.074⟩. ⟨hal-01345732⟩
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2014

ref_biblio
Julien Bouvier. Neurons in motion : spinal networks controlling left-right alternation of walking movements deciphered by genetics/. Médecine/Sciences, 2014, 30 (2), pp.121-4. ⟨10.1051/medsci/20143002002⟩. ⟨hal-01345971⟩
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2013

ref_biblio
Adolfo E Talpalar, Julien Bouvier, Lotta Borgius, Gilles Fortin, Alessandra Pierani, et al.. Dual-mode operation of neuronal networks involved in left-right alternation.. Nature, 2013, 500 (7460), pp.85-8. ⟨10.1038/nature12286⟩. ⟨hal-02394523⟩
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2012

ref_biblio
Muriel Thoby-Brisson, Julien Bouvier, Derrick M Glasco, Michelle E Stewart, Charlotte Dean, et al.. Brainstem Respiratory Oscillators Develop Independently of Neuronal Migration Defects in the Wnt/PCP Mouse Mutant looptail.. PLoS ONE, 2012, 7 (2), pp.e31140. ⟨10.1371/journal.pone.0031140⟩. ⟨hal-00683669⟩
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2011

ref_biblio
Jean Champagnat, Marie-Pierre Morin-Surun, Julien Bouvier, Muriel Thoby-Brisson, Gilles Fortin. Prenatal development of central rhythm generation.. Respiratory Physiology & Neurobiology, 2011, 178 (1), pp.146-55. ⟨10.1016/j.resp.2011.04.013⟩. ⟨hal-00636935⟩
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ref_biblio
Nelina Ramanantsoa, Marie-Rose Hirsch, Muriel Thoby-Brisson, Véronique Dubreuil, Julien Bouvier, et al.. Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.. Journal of Neuroscience, 2011, 31 (36), pp.12880-8. ⟨10.1523/JNEUROSCI.1721-11.2011⟩. ⟨hal-02394503⟩
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2010

ref_biblio
Julien Bouvier, Muriel Thoby-Brisson, Nicolas Renier, Véronique Dubreuil, John Ericson, et al.. Hindbrain Interneurons and Axon Guidance Signalling Critical for Breathing. Nature Neuroscience, 2010, 13 (9), pp.1066-74. ⟨10.1038/nn.2622⟩. ⟨hal-00561814⟩
Accès au texte intégral et bibtex
https://hal.science/hal-00561814/file/PEER_stage2_10.1038%252Fnn.2622.pdf BibTex
ref_biblio
Julien Bouvier, Muriel Thoby-Brisson, Nicolas Renier, Véronique Dubreuil, Johan Ericson, et al.. Hindbrain interneurons and axon guidance signaling critical for breathing.. Nature Neuroscience, 2010, 13 (9), pp.1066-74. ⟨10.1038/nn.2622⟩. ⟨hal-02394517⟩
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2008

ref_biblio
Julien Bouvier, Sandra Autran, Nathalie Dehorter, David M Katz, Jean Champagnat, et al.. Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preBötzinger complex in vitro.. European Journal of Neuroscience, 2008, 28 (3), pp.510-20. ⟨10.1111/j.1460-9568.2008.06345.x⟩. ⟨hal-02394544⟩
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2007

ref_biblio
Julien Bouvier, Sandra Autran, Gilles Fortin, Jean Champagnat, Muriel Thoby-Brisson. Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro.. Journal of Physiology - Paris, 2007, 100 (5-6), pp.290-6. ⟨10.1016/j.jphysparis.2007.05.008⟩. ⟨hal-02394562⟩
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Pré-publication, Document de travail

2024

ref_biblio
Yaroslav I Molkov, Guoning Yu, Jessica Ausborn, Julien Bouvier, Simon M Danner, et al.. Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion. 2024. ⟨hal-04519675⟩
Accès au texte intégral et bibtex
https://hal.science/hal-04519675/file/2023.10.31.564886.full.pdf BibTex

2022

ref_biblio
Coralie Hérent, Séverine Diem, Gilles Fortin, Julien Bouvier. Upregulation of breathing rate during running exercise by central locomotor circuits. 2022. ⟨hal-03851403⟩
Accès au texte intégral et bibtex
https://hal.science/hal-03851403/file/Biorxiv-v1.full.pdf BibTex

2021

ref_biblio
Coralie Hérent, Séverine Diem, Gilles Fortin, Julien Bouvier. Upregulation of breathing rate during running exercise by central locomotor circuits. 2021. ⟨hal-03453523⟩
Accès au texte intégral et bibtex
https://hal.science/hal-03453523/file/2021.07.28.453983v1.full%282%29.pdf BibTex