![](https://neuropsi.cnrs.fr/wp-content/uploads/2021/06/jeanv-barnier-115x150.png)
Institut NeuroPSI - UMR9197
CNRS Université Paris-Saclay
Campus CEA Saclay
Saclay, FRANCE
Dr. Jean-Vianney Barnier
Directeur de Recherche
Cognition, Plasticité & Neuropathologies
jean-vianney.barnier universite-paris-saclay.fr
+33(0)1 69 82 60 47, bureau 3035
ORCID : 0000-0002-2182-0900
Article dans une revue
2024
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- Lucas Baudouin, Noémie Adès, Kadia Kanté, Corinne Bachelin, Hatem Hmidan, et al.. Antagonistic actions of PAK1 and NF2 /Merlin drive myelin membrane expansion in oligodendrocytes. Glia, 2024, 72 (8), pp.1518-1540. ⟨10.1002/glia.24570⟩. ⟨hal-04661896⟩
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- Mayram González-Reyes, Jorge Aragón, Alejandra Sánchez-Trujillo, Griselda Rodríguez-Martínez, Kevin Duarte, et al.. Expression of dystrophin Dp71 splice variants Is temporally regulated during rodent brain development. Molecular Neurobiology, 2024, Online ahead of print. ⟨10.1007/s12035-024-04232-2⟩. ⟨hal-04644501⟩
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- Emmylou C Nicolas-Martinez, Olivia Robinson, Christian Pflueger, Alison Gardner, Mark A Corbett, et al.. RNA variant assessment using transactivation and transdifferentiation. American Journal of Human Genetics, In press, ⟨10.1016/j.ajhg.2024.06.018⟩. ⟨hal-04668148⟩
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- Lucie Viou, Melody Atkins, Véronique Rousseau, Pierre Launay, Justine Masson, et al.. PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity. Molecular Psychiatry, In press, ⟨10.1038/s41380-024-02483-y⟩. ⟨hal-04496726⟩
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2023
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- Natalia Barraza-Núñez, Ramón Pérez-Núñez, Belén Gaete-Ramírez, Alejandra Barrios-Garrido, Christian Arriagada, et al.. Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome. Neurotoxicity Research, 2023, 41 (3), pp.256-269. ⟨10.1007/s12640-023-00638-3⟩. ⟨hal-04050209⟩
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- Andreas Bikfalvi, Cristine Alves da Costa, Tony Avril, Jean-Vianney Barnier, Luc Bauchet, et al.. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends in Cancer, 2023, 9 (1), pp.9-27. ⟨10.1016/j.trecan.2022.09.005⟩. ⟨hal-03860005⟩
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- Manon Dobrigna, Sandrine Poëa-Guyon, Véronique Rousseau, Aline Vincent, Annick Toutain, et al.. The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype. Frontiers in Neuroscience, 2023, 17, pp.1123784. ⟨10.3389/fnins.2023.1123784⟩. ⟨hal-04025933⟩
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2021
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- Lucas Baudouin, Noémie Adès, Kadia Kanté, Antonny Czarnecki, Corinne Bachelin, et al.. Co‐culture of exogenous oligodendrocytes with unmyelinated cerebella: Revisiting ex vivo models and new tools to study myelination. Glia, 2021, 69 (8), pp.1916-1931. ⟨10.1002/GLIA.24001⟩. ⟨hal-04043466⟩
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- Mehdi Belmaati Cherkaoui, Ophélie Vacca, Charlotte Izabelle, Anne‐cécile Boulay, Claire Boulogne, et al.. Dp71 contribution to the molecular scaffold anchoring aquaporine‐4 channels in brain macroglial cells. Glia, 2021, 69 (4), pp.954-970. ⟨10.1002/glia.23941⟩. ⟨hal-03035498⟩
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- Nathalie Magne, Véronique Rousseau, Kévin Duarte, Sandrine Poëa-Guyon, Vincent Gleize, et al.. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. Cellular Oncology, 2021, 44 (6), pp.1257-1271. ⟨10.1007/s13402-021-00635-8⟩. ⟨hal-03439238⟩
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2020
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- Charlotte Castillon, Laurine Gonzalez, Florence Domenichini, Sandrine Guyon, Kévin da Silva, et al.. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. Human Molecular Genetics, 2020, 29 (12), pp.1950-1968. ⟨10.1093/hmg/ddz296⟩. ⟨hal-02459269⟩
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- Kévin Duarte, Solveig Heide, Sandrine Poea-Guyon, Veronique Rousseau, Christel Depienne, et al.. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration. Neurobiology of Disease, 2020, 136, pp.104709. ⟨10.1016/j.nbd.2019.104709⟩. ⟨hal-02937576⟩
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2017
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- Majistor Raj Luxman Maglorius Renkilaraj, Lucas Baudouin, Claire M. Wells, Mohamed Doulazmi, Rosine Wehrlé, et al.. The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation. Neurobiology of Disease, 2017, 98, pp.137--148. ⟨10.1016/j.nbd.2016.12.004⟩. ⟨hal-01543617⟩
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2016
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- Sira A Franchi, Veronica Astro, Romina Macco, Diletta Tonoli, Jean-Vianney Barnier, et al.. Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.. Frontiers in Cellular Neuroscience, 2016, 10, pp.289. ⟨10.3389/fncel.2016.00289⟩. ⟨hal-01572236⟩
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- Ramón Pérez-Núñez, Natalia Barraza, Arlek Gonzalez-Jamett, Ana Maria Cárdenas, Jean-Vianney Barnier, et al.. Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension. Neurotoxicity Research, 2016, 30 (1), pp.76-87. ⟨10.1007/s12640-016-9613-9⟩. ⟨hal-01346998⟩
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2014
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- Julie Piccand, Aline Meunier, Carole Merle, Zhengping Jia, Jean-Vianney Barnier, et al.. Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.. Diabetes, 2014, 63 (1), pp.203-15. ⟨10.2337/db13-0384⟩. ⟨hal-01181234⟩
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2012
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- Gaëlle Combeau, Patricia Kreis, Florence Domenichini, Muriel Amar, Philippe Fossier, et al.. The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.. Journal of Biological Chemistry, 2012, 287 (36), pp.30084-96. ⟨10.1074/jbc.M112.355073⟩. ⟨hal-01182942⟩
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- Aline Dubois, Gaëlle Combeau, Yann Bernardinelli, Jean-Vianney Barnier, Olivier Hartley, et al.. Alteration of Synaptic Network Dynamics by the Intellectual Disability Protein PAK3. Journal of Neuroscience, 2012, 32 (2), pp.519 - 527. ⟨10.1523/JNEUROSCI.3252-11⟩. ⟨hal-01409736⟩
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2011
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- Emmanuelle Thévenot, Alexandre William Moreau, Véronique Rousseau, Gaëlle Combeau, Florence Domenichini, et al.. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.. Journal of Biological Chemistry, 2011, 286 (46), pp.40044-59. ⟨10.1074/jbc.M111.262246⟩. ⟨hal-01182950⟩
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2009
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- Patricia Kreis, Jean-Vianney Barnier. PAK signalling in neuronal physiology.. Cellular Signalling, 2009, 21 (3), pp.384-93. ⟨10.1016/j.cellsig.2008.11.001⟩. ⟨hal-00339765⟩
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2008
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- Patricia Kreis, Véronique Rousseau, Emmanuel Thévenot, Gaëlle Combeau, Jean-Vianney Barnier, et al.. The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.. Journal of Neurochemistry, 2008, 106 (3), pp.1184-97. ⟨10.1111/j.1471-4159.2008.05474.x⟩. ⟨hal-00281504⟩
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2007
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- Patricia Kreis, Emmanuel Thévenot, Véronique Rousseau, Bernadette Boda, Dominique Muller, et al.. The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.. Journal of Biological Chemistry, 2007, 282 (29), pp.21497-506. ⟨10.1074/jbc.M703298200⟩. ⟨hal-00164286⟩
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2006
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- David Romano, Morgane Pertuit, Ramahefarizo Rasolonjanahary, Jean-Vianney Barnier, Karine Magalon, et al.. Regulation of the RAP1/RAF-1/extracellularly regulated kinase-1/2 cascade and prolactin release by the phosphoinositide 3-kinase/Akt pathway in pituitary cells. Endocrinology, 2006, 147 (12), pp.6036-6045. ⟨10.1210/en.2006-0325⟩. ⟨hal-00124784⟩
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2003
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- Xavier Castell, Nathalie Cheviron, Jean-Vianney Barnier, Marie-Françoise Diebler. Exploring the regulation of the expression of ChAT and VAChT genes in NG108-15 cells: implication of PKA and PI3K signaling pathways.. Neurochem Res, 2003, 28 (3-4), pp.557-64. ⟨10.1023/A:1022829608540⟩. ⟨hal-00122267⟩
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- Véronique Rousseau, Olivier Goupille, Nathalie Morin, Jean-Vianney Barnier. A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases.. Journal of Biological Chemistry, 2003, 278 (6), pp.3912-20. ⟨10.1074/jbc.M207251200⟩. ⟨hal-00122266⟩
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2001
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- Etienne Formstecher, Joe W. Ramos, Mireille Fauquet, David A. Calderwood, Jyh-Cheng Hsieh, et al.. PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.. Developmental Cell, 2001, 1 (2), pp.239-50. ⟨10.1016/S1534-5807(01)00035-1⟩. ⟨hal-00122265⟩
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- Catherine Pasqualini, Dominique Guivarc'H, Jean-Vianney Barnier, Jean-Didier Vincent, Bernard Guibert, et al.. Differential subcellular distribution and transcriptional activity of sigmaE3, sigmaE4, and sigmaE3-4 isoforms of the rat estrogen receptor-alpha.. Mol Endocrinol, 2001, 15 (6), pp.894-908. ⟨10.1210/mend.15.6.0642⟩. ⟨hal-00122169⟩
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2000
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- Olivier Goupille, Jean-Vianney Barnier, Bernard Guibert, Jacqueline Paly, Jean Djiane. Effect of PRL on MAPK activation: negative regulatory role of the C-terminal part of the PRL receptor.. Molecular and Cellular Endocrinology, 2000, 159 (1-2), pp.133-46. ⟨10.1016/S0303-7207(99)00197-5⟩. ⟨hal-00122262⟩
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1999
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- Cécile Morice, Fatiha Nothias, Sandra König, Philippe Vernier, Manuela Baccarini, et al.. Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain.. European Journal of Neuroscience, 1999, 11 (6), pp.1995-2006. ⟨10.1046/j.1460-9568.1999.00609.x⟩. ⟨hal-00123365⟩
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- Peter Vanhoutte, Jean-Vianney Barnier, Bernard Guibert, Christiane Pagès, Marie-Jo Besson, et al.. Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c -fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices. Molecular and Cellular Biology, 1999, 19 (1), pp.136-146. ⟨10.1128/mcb.19.1.136⟩. ⟨hal-02372736⟩
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1997
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- Annie Lannuzel, Jean-Vianney Barnier, Christiane Hery, V. Huynh, Bernard Guibert, et al.. Human immunodeficiency virus type 1 and its coat protein gp 120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. Annals of Neurology, 1997, 42 (6), pp.847-856. ⟨10.1002/ana.410420605⟩. ⟨hal-02525249⟩
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- Jean-Didier Vincent, Annie Lannuzel, Jean-Vianney Barnier, Pierre-Marie Lledo, Marc Tardieu. [Experimental study of mechanisms of neuronal death in the course oh HIV infection].. Bulletin de l'Académie Nationale de Médecine, 1997, 181 (4), pp.713-24. ⟨hal-02525260⟩
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1996
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- F. Castets, M. Bartoli, Jean-Vianney Barnier, G Baillat, P. Salin, et al.. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons.. Journal of Cell Biology, 1996, 134 (4), pp.1051-1062. ⟨10.1083/jcb.134.4.1051⟩. ⟨hal-02525281⟩
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- Huynh van Tan, Guillaume Allée, Cyril Benes, Jean-Vianney Barnier, Remi Fagard, et al.. Expression of a Novel Form of the p56lck Protooncogene in Rat Cerebellar Granular Neurons. Journal of Neurochemistry, 1996, 67 (6), pp.2306-2315. ⟨10.1046/j.1471-4159.1996.67062306.x⟩. ⟨hal-02525269⟩
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1995
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- Jean-Vianney Barnier, Catherine Papin, Georges Calothy, Alain Eychène, Odile Lecoq. The Mouse B- raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression. Journal of Biological Chemistry, 1995, 270 (40), pp.23381-23389. ⟨10.1074/jbc.270.40.23381⟩. ⟨hal-02525365⟩
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- Alain Eychène, I Dusanter-Fourt, Jean-Vianney Barnier, Catherine Papin, M Charon, et al.. Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines.. Oncogene, 1995, 10 (6), pp.1159-65. ⟨hal-02525374⟩
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- Catherine Papin, Alain Eychène, A Brunet, G. Pagès, J. Pouyssegur, et al.. B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.. Oncogene, 1995, 10 (8), pp.1647-51. ⟨hal-02525367⟩
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- Catherine Papin, Jean-Vianney Barnier, Alain Eychène, Georges Calothy. [B-raf gene encodes for multiple isoforms with Mek-1 kinase activity].. Comptes rendus des séances de la Société de biologie et de ses filiales, 1995, 189 (1), pp.71-85. ⟨hal-02525378⟩
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- P Peraldi, M Frödin, Jean-Vianney Barnier, V Calleja, Jean-Claude Scimeca, et al.. Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.. FEBS Letters, 1995, 357 (3), pp.290-6. ⟨10.1016/0014-5793(94)01376-C⟩. ⟨hal-02109563⟩
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1994
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- Philippe Dezélée, Jean-Vianney Barnier, J Briest'Anská, Josef Geryk, Ivan Karakoz, et al.. New case of c-src gene transduction: the generation of virus PR2257.. Folia Biologica -Krakow-, 1994, 40 (5), pp.211-23. ⟨hal-02525381⟩
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1993
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- I. Calogeraki, Jean-Vianney Barnier, Alain Eychène, Marie-Paule Felder, Georges Calothy, et al.. Genomic Organization and Nucleotide Sequence of the Coding Region of the Chicken c-Rmil(B-raf-1) Proto-oncogene. Biochemical and Biophysical Research Communications, 1993, 193 (3), pp.1324-1331. ⟨10.1006/bbrc.1993.1770⟩. ⟨hal-02525383⟩
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1992
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- Philippe Dezélée, Jean-Vianney Barnier, Annie Hampe, Danielle Laugier, Maria Marx, et al.. Small deletion in v-src SH3 domain of a transformation defective mutant of rous sarcoma virus restores wild type transforming properties. Virology, 1992, 189 (2), pp.556-567. ⟨10.1016/0042-6822(92)90579-e⟩. ⟨hal-02525721⟩
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- Alain Eychène, Jean-Vianney Barnier, Philippe Dezélée, Maria Marx, Danielle Laugier, et al.. Quail neuroretina c-Rmil(B-raf) proto-oncogene cDNAs encode two proteins of 93.5 and 95 kDa resulting from alternative splicing.. Oncogene, 1992, 7 (7), pp.1315-23. ⟨hal-02525730⟩
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- Alain Eychène, Jean-Vianney Barnier, F Apiou, B. Dutrillaux, Georges Calothy. Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.. Oncogene, 1992, 7 (8), pp.1657-60. ⟨hal-02525714⟩
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1991
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- Marie-Paule Felder, Alain Eychène, Jean-Vianney Barnier, Maria Marx, I. Calogeraki, et al.. Common mechanism of retrovirus activation and transduction of c-mil and c-Rmil in chicken neuroretina cells infected with Rous-associated virus type 1.. Journal of Virology, 1991, 65 (7), pp.3633-40. ⟨hal-02525739⟩
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1990
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- Jean-Vianney Barnier, Maria Marx, Philippe Dezélée, Danielle Laugier, Miroslav Hill, et al.. Transformation-defective mutants with 5′ deletions of the src gene are frequently generated during replication of rous sarcoma virus in established quail fibroblasts. Virology, 1990, 177 (2), pp.505-514. ⟨10.1016/0042-6822(90)90515-s⟩. ⟨hal-02525749⟩
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1989
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- Jean-Vianney Barnier, Philippe Dezélée, Maria Marx, Georges Calothy. Nucleotide sequence of the src gene of the Schmidt - Ruppin strain of Rous Sarcoma virus type E. Nucleic Acids Research, 1989, 17 (3), pp.1252-1252. ⟨10.1093/nar/17.3.1252⟩. ⟨hal-02525770⟩
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- Josef Geryk, Philippe Dezélée, Jean-Vianney Barnier, J. Svoboda, Jiří Nehyba, et al.. Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.. Journal of Virology, 1989, 63 (2), pp.481-92. ⟨hal-02525776⟩
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- Vincent Legagneux, Valérie Mezger, Carole Quélard, Jean-Vianney Barnier, Oliver Bensaude, et al.. High constitutive transcription of HSP86 gene in murine embryonal carcinoma cells. Differentiation, 1989, 41 (1), pp.42-48. ⟨10.1111/j.1432-0436.1989.tb00730.x⟩. ⟨hal-02525758⟩
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1987
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- Jean-Vianney Barnier, Oliver Bensaude, Michel Morange, Charles Babinet. Mouse 89 kD heat shock protein. Experimental Cell Research, 1987, 170 (1), pp.186-194. ⟨10.1016/0014-4827(87)90128-5⟩. ⟨hal-02525792⟩
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- Danielle Laugier, Maria Marx, Jean-Vianney Barnier, Françoise Poirier, P Genvrin, et al.. N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.. Journal of Virology, 1987, 61 (8), pp.2523-9. ⟨hal-02525787⟩
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1984
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- M. Lievremont, Jean-Vianney Barnier, J. Potus. γ-Hexachlorocyclohexane inhibition of the calcium fluxes at the desensitized mouse neuromuscular junction. Toxicology and Applied Pharmacology, 1984, 76 (2), pp.280-287. ⟨10.1016/0041-008x(84)90009-7⟩. ⟨hal-02525805⟩
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