Équipe Muriel Perron

Cellules souches et neurogenèse dans la rétine (SCaNR)
Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)
Les publications


> Masson C., García-García D., Bitard J., Grellier É-K., Roger J.E., Perron M. (2020). Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy. bioRxiv.02.18.953943.

> García-García D., Locker M., Perron M. (2020). Update on Müller glia regenerative potential for retinal repair. Curr Opin Genet Dev Jun 30;64:52-59.


> Linking YAP to Müller glia quiescence exit in the degenerative retina (2019). Hamon A.*, García-García, D.*, Ail, D.*, Bitard, J., Chesneau, A., Dalkara, D., Locker, M., Roger, J.E. § and Perron, M. § (2019). Cell Reports 27(6):1712-1725.


> Conditional chemogenetic ablation of photoreceptor cells in Xenopus retina (2018). Chesneau A.*, Bronchain O.* and Perron M. Methods in Molecular Biology , Springer Nature, 1865:133-146.
> Cone-rod homeobox CRX controls presynaptic active zone formation in photoreceptors of mammalian retina. (2018). Assawachananont J., Kim S.Y., Kaya K.D., Fariss R., Roger J.E., Swaroop A. Hum Mol Genet. Jul 31.
> An atlas of Wnt activity during embryogenesis in Xenopus tropicalis (2018). Borday C. §, Parain K. §, Tran H.T., Vleminckx K., Perron M.§ and Anne-Hélène Monsoro-Burq A.H.§ Plos One 13(4):e0193606.
> Repopulating microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation (2018). Zhang Y., Zhao L., Wang X., Ma X., Lazere A., Qian H.H., Zhang J., Abu-Asab M., Fariss R.N., Roger J.E., Wong W.T. Sci Adv. 21 EAAP8492.


> Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation (2017). Campla, C.K., Breit, H., Dong, L., Gumerson, J.D., Roger, J.E., and Swaroop, A. Biol. Open 6, 881–890.
> Müller glial cell reactivation in Xenopus models of retinal degeneration (2017). Langhe R, Chesneau A, Colozza G, Hidalgo M, Locker M and Perron M. Glia 65(8):1333-1349.
> Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina (2017). Bessodes N, Parain K, Bronchain O, Bellefroid EJ, Perron M. Neural Development 2017 12(1):16.
> Shaping of the photoreceptor outer segment by the calyceal processes of the inner segment (2017). Schietroma C, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel J-A, Perron M, El-Amraoui and Petit C. Journal of Cell Biology 216(6):1849-1864.
> Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells (2017). Hamon A, Masson C, Bitard B, Gieser L, Roger JE, Perron M. IOVS 58 : 1941-1953.
> Retinal Degeneration and Regeneration-Lessons From Fishes and Amphibians (2017). Ail D & Perron M. Current Pathobiology Reports 5(1) : 67-78.


> Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development (2016). Pfirrmann T, Jandt E, Ranft S, Lokapally A, Neuhaus H, Perron M & Hollemann T. Proc Natl Acad Sci U S A. 113(36):10103-8.
> Müller glial cell-dependent regeneration of the neural retina : An overview across vertebrate model systems (2016). Hamon A, Roger JE, Yang XJ, Perron M. Dev Dyn. 245(7):727-38.


> YAP controls retinal stem cell DNA replication timing and genomic stability. (2015). Cabochette P*, Vega-Lopez G*, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O§ & Perron M§. eLife 4:e08488.
> Post in The Node on October 7th, 2015


> Ascl1 as a novel player in the Ptf1a transcriptional network for GABAergic cell specification in the retina. (2014). Mazurier N*, Parain K*, Parlier D, Pretto S, Vernier P, Locker M, Bellefroid E & Perron M. Plos One 9(3):e92113.
> The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbp-j downstream target that promotes GABAergic over glutamatergic neuronal fate in the dorsal neural tube. (2014). Hanotel J, Bessodes N, Thélie A, Hedderich M, Parain K, Van Driessche B, Oliveira Brandao K, Kricha S, Jorgensen M, Grapin-Botton A, Serup P, Van Lint C, Perron M, Pieler T, Henningfeld KA & Bellefroid EJ. Developmental Biology 386:340-57.
> Adult neurogenesis and regeneration in amphibian retina. (2014). Hidalgo M*, Locker M*, Chesneau A & Perron M. In Regenerative Biology of the Eye, Ed Springer. Chapter 4, 83-99.


> New advances in morphogen gradient modelling. (2013). Locker M & Perron M. Physics of Life Reviews 10(4) : 478-9. Reply to Comments 10(4) : 495-497


> A bromodeoxyuridine (BrdU) based protocol for characterizing proliferating progenitors in Xenopus embryos. (2012). Auger H, Thuret R, El Yakoubi W, Papalopulu N. In Methods Mol. Biol., Xenopus Protocols 917:461-75.
> Shaping the eye from embryonic stem cells : Biological and medical implications. (2012). Colozza G, Locker M & Perron M World J Stem Cells 4(8):80-86.
> Live Imaging of Targeted Cell Ablation in Xenopus : A New Model to Study Demyelination and Repair. (2012). Kaya F, Mannioui A, Chesneau A, Sekizar S, Maillard E, Ballagny C, Houel-Renault L, Dupasquier D, Bronchain O, Holtzmann I, Desmazieres A, Thomas JL, Demeneix BA, Brophy PJ, Zalc B & Mazabraud A. J Neurosci. 32(37):12885-12895.
> Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis. (2012). El Yakoubi W, Borday C, Hamdache J, Parain K, Tran HT, Vleminckx K, Perron M§ & Locker M§ Stem Cells 30(12):2784-95
> Cover of the December 2012 journal issue
> Antagonistic cross-regulation between Wnt and Hedgehog signaling pathways controls post-embryonic retinal proliferation. (2012). Borday C*, Cabochette P*, Parain K, Mazurier N, Janssens S, Tran HT, Sekkali B, Bronchain O, Vleminckx K, Locker M & Perron M. Development 139(19):3499-509.
> A large scale screen for neural stem cell markers in Xenopus retina. (2010). Parain K*, Mazurier N*, Bronchain O, Borday C, Cabochette P, Chesneau A, Colozza G, el Yakoubi W, Hamdache J, Gilchrist M, Pollet N & Perron M. Developmental Neurobiology 72(4):491-506.


> 3D revolution of stem cells : building a retina in vitro. (2011). Perron M. Médecine/Sciences 2011 Aug-Sep ;27(8-9):709-12.
> Degeneration and Regeneration in the Vertebrate Retina (2011). Colozza G, Mazabraud A & Perron M. Advances in Regenerative Medicine, Dr Sabine Wislet-Gendebien (Ed.), ISBN : 978-953-307-732-1, InTech, DOI : 10.5772/25843.
> Stem cells to repair retina : from basic to applied biology. (2011). Perron M, Locker M & Bronchain O. In Stem Cells and Cancer Stem Cells, Ed Springer. Volume 2 Part 4, 299-306, DOI : 10.1007/978-94-007-2016-9_32.


> A decade of mammalian retinal stem cell research. (2010). Locker M, El Yakoubi W, Mazurier N, Dullin JP & Perron M. Arch Ital Biol. 148:59-72.


> A Database of Queryable Gene Expression Patterns for Xenopus. (2009). Gilchrist M J., M Christensen, O Bronchain, F Brunet, A Chesneau, U Fenger, T Geach, H Ironfield, F Kaya, S Kricha, R Lea, K Masse, I Néant, E Paillard, K Parain, M Perron, L Sinzelle, J Souopgui, R Thuret, Q Ymlahi-Ouazzani & N Pollet. Developmental Dynamics Special Issue : Special Focus on Xenopus. 238(6):1379-88.
> Highlights in DD, Developmental Dynamics October 2009
> The role of Xenopus Rx-L in photoreceptor cell determination. (2009). Wu H.Y., Perron M. & Hollemann T. Developmental Biology 327(2):352-65.
> Stemness or not stemness ? Current status and perspectives of adult retinal stem cells. (2009). Locker M, Borday C. & Perron M. (2009). Current stem cell research & Therapy 4(2):118-30
> Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy. (2009). Bronchain O, Ymlahi-Ouazzani Q, Paillard E, Ballagny C, Chesneau A, Jadaud A, Mazabraud A & Pollet N. Neurogenetics Jun 11.


> Sponge Genes Provide New Insight into the Evolutionary Origin of the Neurogenic Circuit. (2008). Richards G, Simionato E, Perrron M, Adamska M, Vervoort M & Degnan B M. Current Biology 18(15):1156-61.
> Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes.(2008). Denayer T*, Locker M*, Borday C, Deroo T, Janssens S, Hecht A, van Roy F, Perron M§ & Vleminckx K.§ Stem Cells 26(8):2063-74.
> Transgenesis procedures in Xenopus. (2008). Chesneau A, Sachs LM, Chai N, Chen Y, Du Pasquier L, Loeber J, Pollet N, Reilly M, Weeks DL & Bronchain OJ. Biol Cell. 100(9):503-21.


> Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis. (2007). Fierro AC, Thuret R, Coen L, Perron M, Demeneix BA, Wegnez M, Gyapay G, Weissenbach J, Wincker P, Mazabraud A & Pollet N. BMC Genomics 16(8):118
> Neuron and glial cell differentiation in Xenopus. (2007). Henningfeld, K., Locker M & Perron, M. Functional Development and Embryology 1, 26-36.
> Ptf1a triggers GABAergic neuronal cell fates in the retina.(2007). Dullin JP*, Locker M*, Robach M*, Henningfeld KA, Parain K, Afelik S, Pieler T & Perron M. BMC Dev Biol. 2(7):110.
> A general role of hedgehog in the regulation of proliferation.(2007). Agathocleous M, Locker M, Harris WA & Perron M. Cell Cycle 6(2):156-9.
> The olig family : phylogenetic analysis and early gene expression in Xenopus tropicalis. (2007). Bronchain OJ, Pollet N, Ymlahi-Ouazzani Q, Dhorne-Pollet S, Helbling JC, Lecarpentier JE, Percheron K & Wegnez M. Dev Genes Evol. 217(7):485-97.
> Regulation of XSnail2 expression by RhoGTPases. (2007). Florence Broders-Bondon, Albert Chesneau, Francisco Romero-Oliva, André Mazabraud, Roberto Mayor & Jean Paul Thiery. Dev.Dyn. 236(9):2555-66.


> Hedgehog signaling and the retina : insights into the mechanisms controlling the proliferative properties of neural precursors. (2006). Locker, M.*, Agathocleous, M.*, Amato, M.A., Parain, K., Harris, W.A. & Perron, M. Genes and Development 20 : 303—6-048.
> This article was recommended in F1000Prime, 10 Oct 2015 ; F1000Prime.com/1061749
> Characterization and function of the bHLH-O protein XHes2 : insight into the mechanisms controlling retinal cell fate decision. (2006). Sölter, M. *, Locker, M. *, Boy, S., Taelman, V., Bellefroid, E.J. & Perron, M.§, and Pieler, T.§ Development 133, 4097-4108.
> Transcription enhancer factor-1-dependent expression of the alpha-tropomyosin gene in the three muscle cell types. (2006). Pasquet S, Naye F, Faucheux C, Bronchain O, Chesneau A, Thiébaud P & Thézé N. J. Biol. Chem. 10 ;281(45):34406-20.
> Survivin increased vascular development during Xenopus ontogenesis.(2006). Du Pasquier D, Phung AC, Ymlahi-Ouazzani Q, Sinzelle L, Ballagny C, Bronchain O, Du Pasquier L & Mazabraud A. Differentiation 74(5):244-53.
> Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation. (2006). Van Campenhout C, Nichane M, Antoniou A, Pendeville H, Bronchain OJ, Marine JC, Mazabraud A, Voz ML & Bellefroid EJ. Dev. Biol. 1 ;294(1):203-19.
> Generation of trangenic Xenopus laevis using the Sleeping Beauty transposon system. (2006). Sinzelle L, Vallin J, Coen L, Chesneau A, Du Pasquier D, Pollet N, Demeneix B & Mazabraud A. Transgenic Research 15, 751-760.
> TBid mediated Activation of the Mitochondrial Death Pathway leads to Genetic Ablation of the lens in Xenopus laevis. (2006). D. Du Pasquier, A. Chesneau, N. Pollet, C. Ballagny, L.M. Sachs, B. Demeneix & A. Mazabraud. Genesis 45, 1-10.
> The mariner transposons belonging to the irritans subfamily were maintained in chordate genomes by vertical transmission. (2006). Ludivine Sinzelle, Albert Chesneau, Yves Bigot, André Mazabraud & Nicolas Pollet. Journal of Molecular Evolution 62, 53-65.
> Developmental cell death during Xenopus metamorphosis involves Bid cleavage and caspase 2 and 8 activation. (2006). D. Du Pasquier, V. Rincheval, L. Sinzelle, A. Chesneau, C. Ballagny, LM. Sachs, B. Demeneix & A. Mazabraud. Dev Dyn. 235:2083-2094.


> Comparison of the expression of five neural-specific RNA binding proteins in the Xenopus retina. (2005). Amato M.A., Boy S., Arnault E., Della Puppa A., Girard M., Sharif A. & Perron M. Journal of Comparative Neurology 481 : 331-339.
> Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. (2005). Coolen M, Sii-Felice K, Bronchain O, Mazabraud A, Bourrat F, Rétaux S, Felder-Schmittbuhl MP, Mazan S, Plouhinec JL. Dev. Genes Evol. 215(7):327-39.


> Retinal stem cells in vertebrates : parallels and divergences.(2004). Amato M.A., Arnault E. and Perron M. Int. J Dev Biol. "Eye development" special issue 48 : 993-100.
> RNA binding proteins and neural development : a matter of targets and complexes. (2004). Agnès F. and Perron M. NeuroReport 15(17):2567-70.
> XSEB4R, a novel RNA-binding protein involved in retinal cell differentiation downstream of bHLH proneural genes. (2004). Boy S., Souopgui J., Amato M.A., Wegnez M., Pieler T. and Perron M. Development 131 : 851-62.
> Hedgehog signalling in vertebrate retinal development : a growing puzzle. (2004). Amato M.A., Boy S. and Perron M. Cellular and Molecular Life Sciences 61(7-8):899-910.


> A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. (2003). Perron M, Boy S, Amato MA, Viczian A, Koebernick K, Pieler T, Harris WA. Development 130:1565-77.


> Lipofection strategy for the study of Xenopus retinal development. (2002). Ohnuma S, Mann F, Boy S, Perron M, Harris WA. Methods 28:411-9.


> Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis. (2001). Nutt SL, Bronchain OJ, Hartley KO, Amaya E. Genesis 30(3):110-3.


> Retinal stem cells in vertebrates. (2000). Perron, M. and Harris, W.A. Bioessays 22, 685-688.
> Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors. (2000). Perron, M. and Harris, W.A. Cellular and Molecular Life Sciences 57 : 215-223.

* Co-first authors
§ Co-corresponding authors