Équipe François Rouyer

Génétique Moléculaire des Rythmes Circadiens
Les publications

Articles parus dans des revues avec comité de lecture


• Rouyer, F., and Chatterjee, A. (2020). Circadian Clocks: Structural Plasticity on the Input Side. Curr Biol 30, R890-R893. (Pubmed)


• Hubert A, Harms F, Juvénal R, Treimany P, Levecq X, Loriette V, Farkouh G, Rouyer F, Fragola A. (2019). Adaptive optics light-sheet microscopy based on direct wavefront sensing without any guide star. Opt Lett. 44(10): 2514-2517. (Pubmed)

• Grima, B., Papin, C., Martin, B., Chélot, E., Ponien, P., Jacquet, E., and Rouyer, F. (2019). PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock. Proc Natl Acad Sci U S A 116, 5721-5726. (Pubmed)

• Alejevski, F., Saint-Charles, A., Michard-Vanhée, C., Martin, B., Galant, S., Vasiliauskas, D., and Rouyer, F. (2019). The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles. Nat Commun 10, 252. (Pubmed)


• Sherrard, R. M., Morellini, N., Jourdan, N., El-Esawi, M., Arthaut, L. D., Niessner, C., Rouyer, F., Klarsfeld, A., Doulazmi, M., Witczak, J., d’Harlingue, A., Mariani, J., Mclure, I., Martino, C. F., and Ahmad, M. (2018). Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species. PLoS Biol 16, e2006229. (Pubmed)

• Chatterjee, A., Lamaze, A., De, J., Mena, W., Chélot, E., Martin, B., Hardin, P., Kadener, S., Emery, P., and Rouyer, F. (2018). Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock. Curr Biol 28, 2007-2017. (Pubmed)

• Szabó, Á., Papin, C., Cornu, D., Chélot, E., Lipinszki, Z., Udvardy, A., Redeker, V., Mayor, U., and Rouyer, F. (2018). Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS during a Circadian Cycle. Cell Rep 23, 2273-2282. (Pubmed)

• Arganda-Carreras, I., Manoliu, T., Mazuras, N., Schulze, F., Iglesias, J. E., Bühler, K., Jenett, A., Rouyer, F., and Andrey, P. (2018). A Statistically Representative Atlas for Mapping Neuronal Circuits in the Drosophila Adult Brain. Front Neuroinform 12, 13. (Pubmed)


• Klarsfeld, A., Birman, S., and Rouyer, F. (2018). Nobel time for the circadian clock Nobel Prize in Medicine 2017: Jeffrey C. Hall, Michael Rosbash and Michael W. Young. Med Sci (Paris) 34, 480-484. (Pubmed)


• Chatterjee, A., and Rouyer, F. (2016). Control of sleep-wake cycles in Drosophila. In A time for metabolism and hormones, Sassone-Corsi, P., and Y. Christen, Springer), pp. 71-78.(Pubmed)

• Saint-Charles, A., Michard-Vanhée, C., Alejevski, F., Chélot, E., Boivin, A., and Rouyer, F. (2016). Four of the six Drosophila Rhodopsin-expressing photoreceptors can mediate circadian entrainment in low light. J Comp Neurol 524, 2828-2844. (Pubmed)


• Rouyer, F., and Chatterjee, A. (2015). Circadian clocks: A receptor for subtle temperature changes. Nature 527, 449-451. (Pubmed)

• Rouyer, F. (2015). Gènes d’horloge: de la drosophile à l’homme. Bull Acad Natl Med 199, 1115-1131. (Pubmed)

• Andreazza, S., Bouleau, S., Martin, B., Lamouroux, A., Ponien, P., Papin, C., Chélot, E., Jacquet, E., and Rouyer, F. (2015). Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila. Cell Rep 11, 1266-1279. (Pubmed)


• Szabo, A., Papin, C., Zorn, D., Ponien, P., Weber, F., Raabe, T., and Rouyer, F. (2013). The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator. PLoS Biol 11, e1001645. (Pubmed)

• Rouyer, F. (2013). Circadian Timing. In Neurosciences. From Molecule to Behavior: a university textbook, Ed: Galizia, C. G. and P.-M. Lledo.(Springer Spektrum), pp. 609-628.


• Grima, B., Dognon, A., Lamouroux, A., Chelot, E., and Rouyer, F. (2012). CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock. PLoS Biol 10, e1001367. (Pubmed)

• Rouyer, F. (2012). Circadian rhythms: No lazing on sunny afternoons. Nature 484, 325-326. (Pubmed

• Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., Helfrich-Forster, C., Soubigou, G., Coppee, J. Y., Klarsfeld, A., Rouyer, F., Scrutton, N. S., and Ahmad, M. (2012). Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. PLoS One 7, e31867. (Pubmed)


• Klarsfeld, A., Picot, M., Vias, C., Chelot, E., and Rouyer, F. (2011). Identifying specific light inputs for each subgroup of brain clock neurons in Drosophila larvae. J Neurosci 31, 17406-17415. (Pubmed)

• Lamaze, A., Lamouroux, A., Vias, C., Hung, H. C., Weber, F., and Rouyer, F. (2011). The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. EMBO Rep 12, 549-557. (Pubmed)

• Rouyer, F. (2011). Les insectes, horloges modèles. Biofutur 30, 28-30.


• Cusumano, P., Klarsfeld, A., Chélot, E., Picot, M., Richier, B., and Rouyer, F. (2009). PDF-modulated visual inputs and Cryptochrome define diurnal behavior in Drosophila. Nat Neurosci 12, 1427-1433. (Pubmed)

• Johard, H. A., Yoishii, T., Dircksen, H., Cusumano, P., Rouyer, F., Helfrich-Forster, C., and Nassel, D. R.(2009). Peptidergic clock neurons in Drosophila: Ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons. J Comp Neurol 516, 59-73. (Pubmed)

• Rieger, D., Wulbeck, C., Rouyer, F., and Helfrich-Forster, C. (2009). Period gene expression in four PDF-negative Lateral Neurons is sufficient for rhythmic activity of Drosophila melanogaster under dim light conditions. J Biol Rhythms 24, 271-282. (Pubmed)

• Picot, M., Klarsfeld, A., Chélot, E., Malpel, S., and Rouyer, F. (2009). A role for blind DN2 clock neurons in temperature entrainment of the Drosophila larval brain. J Neurosci 29, 8312-8320. (Pubmed)


• Rouyer, F. (2008). Physiology: Mutant flies lack magnetic sense. Nature 454, 949-951. (Pubmed)

• Richier, B., Michard-Vanhée, C., Lamouroux, A., Papin, C., and Rouyer, F. (2008). The Clockwork Orange Drosophila Protein Functions as Both an Activator and a Repressor of Clock Gene Expression. J Biol Rhythms 23, 103-116. (Pubmed)


• Picot, M., Cusumano, P., Klarsfeld, A., Ueda, R., and Rouyer, F. (2007). Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock. PLoS Biol 5, e315. (Pubmed)

• Helfrich-Forster, C., Yoshii, T., Wülbeck, C., Grieshaber, E., Rieger, D., Bachleitner, W., Cusumano, P., and Rouyer, F. (2007). The Lateral and Dorsal Neurons of Drosophila melanogaster: New insights about their morphology and function. Cold Spring Harb Symp Quant Biol 72, 517-525. (Pubmed)


• Rouyer, F. (2005). Des horloges du matin et du soir dans le cerveau de la drosophile. Med Sci (Paris) 21, 808-810. (Pubmed)


• Grima, B., Chélot, E., Xia, R., and Rouyer, F. (2004). Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature 431, 869-873. (Pubmed)

• Klarsfeld, A., Malpel, S., Michard-Vanhée, C., Picot, M., Chélot, E., and Rouyer, F. (2004). Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci 24, 1468-1477. (Pubmed)

• Malpel, S., Klarsfeld, A., and Rouyer, F. (2004). Circadian synchronization and rhythmicity in larval photoperception-defective mutants of Drosophila. J Biol Rhythms 19, 10)-21. (Pubmed)


• Klarsfeld, A., Leloup, J. C., and Rouyer, F. (2003). Circadian rhythms of locomotor activity in Drosophila. Behav Processes 64, 161-175. (Pubmed)


• Grima, B., Lamouroux, A., Chélot, E., Papin, C., Limbourg-Bouchon, B., and Rouyer, F. (2002). The F-box protein SLIMB controls the levels of clock proteins PERIOD and TIMELESS. Nature 429, 178-182. (Pubmed)

• Malpel, S., Klarsfeld, A., and Rouyer, F. (2002). Larval optic nerve and adult extra-retinal photoreceptors sequentially associate with the clock neurons during Drosophila brain development. Development 129, 1443-1453. (Pubmed)


• Blanchardon, E., Grima, B., Klarsfeld, A., Chélot, E., Hardin, P. E., Préat, T., and Rouyer, F. (2001). Defining the role of Drosophila lateral neurons in the control of circadian activity and eclosion rhythms by targeted genetic ablation and PERIOD protein overexpression. Eur J Neurosci 13, 871-888. (Pubmed)


• Rouyer, F. (1998). Chez la drosophile, les horloges circadiennes ont leur propres yeux. Med Sci (Paris) 14, 448-450.

• Klarsfeld, A., and Rouyer, F. (1998). Effects of circadian mutations and LD periodicity on the life span of Drosophila melanogaster. J Biol Rhythms 13, 471-478. (Pubmed)


• Rachidi, M., Lopes, C., Benichou, J.-C., and Rouyer, F. (1997). Analysis of period circadian expression in the Drosophila head by in situ hybridization. J Neurogenet 11, 255-263. (Pubmed)