Lundi 4 novembre 2019 - 11h00, Amphi NeuroSpin
Centre d'études de Saclay - Gif-Sur-Yvette
« Dopamine as a neuromodulator of exploration : consequence on individual traits and vulnerability to drug of abuse »
Philippe FAURE, Neuroscience Paris Seine, Sorbonne Université
The susceptibility to develop drug addiction differs substantially between individuals. Among the predictive factors that have been implicated are personality traits such as impulsivity, exploration or novelty seeking. Using an interdisciplinary approach that combines electrophysiology, genetic manipulation of circuits and behavioral analysis, we will analyze exploratory behaviors and reactions to uncertainty, two major components of mouse personality, and link modifications of midbrain dopamine cells to modulation of such behaviors. By analyzing mice behaviors in a semi-naturalistic environment, I will also explore the causal role of social relationships in the shaping of intra-individual behavioral variabilities and show that the composition of social groups affects non-social behavioral traits and the underlying decision-making system. By acting on the dopamine system, the social context may indeed affect the capacity of individuals to take decision and consequently their vulnerability to drugs of abuse.
« La rapidité de l’action : mécanismes multiples, déterminants cérébraux et relations avec les fonctions exécutives de contrôle cognitif. »
Invitation : Sylvie Granon (Neurobiologie de la prise de décision)
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