Jobs

COME AND WORK AT NeuroPSI

Would you like to work in the field of neuroscience? Come and join one of the 22 NeuroPSI teams.

This page presents our offers for PhD, post-doc, fixed-term contracts for engineers and technicians, fixed-term administrative contracts, etc.

If you are looking for an internship, click here.

OUR JOB OFFERS

Research Engineer

Post-doctoral researcher (F/M)

12 months
The missions will be part of a collaborative research project on the physiological role of the Aη peptide in modulating the NMDA receptor, and its impact on brain function and cognition in mice.
Thanks to transgenic animals over-expressing or under-expressing the Aη peptide, the researcher will carry out a characterization of the role of this peptide in social behavior (test of social motivation, social interaction with measurement of ultrasonic vocalizations with two or four animals) and in anxious behaviors.

General information
• Reference : UMR9197-ODILEC2-109
• Workplace : SACLAY
• Date of publication : Tuesday, June 28, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 1 January 2023
• Proportion of work : Full time
• Remuneration : between €2743 and €3896 gross per month, depending on professional experience and CNRS salary scale
• Desired level of education : PhD
• Experience required : 1 to 4 years

Missions
The missions will be part of a collaborative research project on the physiological role of the Aη peptide in modulating the NMDA receptor, and its impact on brain function and cognition in mice.
Thanks to transgenic animals over-expressing or under-expressing the Aη peptide, the researcher will carry out a characterization of the role of this peptide in social behavior (test of social motivation, social interaction with measurement of ultrasonic vocalizations with two or four animals) and in anxious behaviors. Depending on the deficits observed in animals under expressing Aη, rescue strategies by adding Aη will make it possible to confirm the role of this peptide. The recruited person will be able to participate in the histological analyzes carried out on the brains.

Activities
• conduction of behavioral experiments on males and females
• video and audio data analysis of social behaviors
• support for the development and conduction of four-animal social interaction experiments in automated devices
• histological analyzes

Skills
• Knowledge of animal (rodent) behavior and data analysis in this area, including statistical analysis, required.
• Legal authorization for animal experimentation is required
• Fluency in English (oral and written) required
• Having the regulatory surgical training is a plus.
• Programming basics (python, matlab) are a plus.
General skills
• Teamwork, written communication, organization, independence

Work Context
The building of the Paris-Saclay Institute of Neurosciences -NeuroPSI- is located on the CEA site in Saclay, next to the NeuroSpin brain imaging institute. Behavioral experiments will take place at NeuroPSI.
NeuroPSI includes 21 research teams, platforms and technical services allowing the study of brain function in several animal models at all levels. The postdoctoral researcher will work in the team led by Sylvie Granon, Neurobiology of decision-making (en/departments/cnn/group-leader-sylvie-granon/). This team includes 2 teacher-researchers, 2 CNRS researchers, an emeritus CNRS researcher and 3 thesis students (3rd, 2nd and 1st year).
Access to the CEA site is served by a bus service from the RER the counter and Massy. Nevertheless, the transport time from Paris requires several changes and is around 1h20 minutes, around 40 minutes by car depending on traffic.

Contact
Alexis Faure

Post-Doc

Post-doc in bioacoustics

6 months
The post-doc reseracher will participate to developping, in the field, on-board sound recordings in birds. He will collect acoustic and behavioural data. He will futher process acoustic data using semi-automated analysis.

General information
• Reference : UMR9197-ODILEC2-110
• Workplace : SACLAY
• Date of publication : Tuesday, July 5, 2022
• Type of Contract : FTC Scientist
• Contract Period : 6 months
• Expected date of employment : 1 January 2023
• Proportion of work : Full time
• Remuneration : gross monthly salary between 2743,70 et 3896,74 € depending on experience (according to the CNRS salary scale)
• Desired level of education : PhD
• Experience required : Indifferent

Missions
The post-doc reseracher will participate to developping, in the field, on-board sound recordings in birds. He will collect acoustic and behavioural data. He will futher process acoustic data using semi-automated analysis.

Activities
Field work (birds handling, acoustic recordings, behavioural monitoring), and work on computer (acoustic analysis and data analysis).

Skills
To be an expert in bioacoustic. To be a researcher in animal behaviour. To have solid experience of working in the field.

Work Context
The scientific project of studying the behaviour of a colonial bird with a cooperative reproduction system, the sociable weaver (Philetairus socius) is led by the team Animal Sociality from the Institut CIBIO-InBIO (Portugal) and the team Ecologie spatiale des populations from the CEFE (UMR5175, Montpellier), in collaboration with Fanny Rybak from the team Communications Acoustiques from the NeuroPSI (UMR9197, Saclay). The project relies on the longest duration of monitoring of passerines in South Africa, gathering annually data on reproduction, behavior, and cooperation of a population of 600 birds. A part of the project is devoted to the study of acoustic communication in Ploceidae in general, and in the sociable weaver in particular, and especially the importance of vocalisations in sexual selection (Extended Phenotype project, funded by ANR).

Contact
Fanny Rybak

Postdoctoral Neurobiology and therapy of visual disorders associated with neurodevelopmental pathologies

24 months
The candidate will take autonomous responsibility for a comparative study of several mouse models of a neurodevelopmental pathology, will develop tools for gene therapy and for the analysis of electrophysiological signals in interaction with foreign collaborators and clinicians, and will participate in the training of interns and technical staff.

General information
• Reference : UMR9197-ODILEC2-108
• Workplace : SACLAY
• Date of publication : Thursday, June 16, 2022
• Type of Contract : FTC Scientist
• Contract Period : 24 months
• Expected date of employment : 1 October 2022
• Proportion of work : Full time
• Remuneration : gross monthly salary between €2700 and €3800 depending on experience (according to the CNRS salary scale)
Desired level of education : 5-year university degree
• Experience required : Indifferent

Missions
The candidate will take autonomous responsibility for a comparative study of several mouse models of a neurodevelopmental pathology, will develop tools for gene therapy and for the analysis of electrophysiological signals in interaction with foreign collaborators and clinicians, and will participate in the training of interns and technical staff.

Activities
The study will be mainly based on in vivo electrophysiological approaches (ERG) complemented by intraocular injections of treatments, behavioural tests, cellular and molecular analyses by confocal microscopy, and statistics. New protocols and tools for ERG signal analysis and statistics will be developed in collaboration. The candidate will write regular reports in English on the progress of his/her work, as well as conference papers and publications.

Skills
The candidate must be proficient in in vivo electroretinographic recordings in anesthetized mice, ERG signal analysis and English (written and spoken). Certification in animal experimentation is desired. Experience or expertise in ERG and psychophysical measurements in animals and/or humans, intraocular injections in mice, and/or immunohistochemistry and confocal microscopy techniques will be appreciated, but is not mandatory as these techniques can be learned during the project.

Work Context
The postdoctoral fellowship will be carried out in the “Plasticity, Cognition and Neuropathologies” team led by Cyrille Vaillend in the “Cognitive and Network Neuroscience” department (CNN) of the Paris-Saclay Institute of Neuroscience. The project is part of a funded international and multidisciplinary research program; interactions and training periods will involve other teams of the Institute, and an international collaborative network including ophthalmologists, psychophysiologists, neurophysiologists and molecular biologists in France and abroad (Germany, Hungary, Brazil). The salary will depend on the candidate’s experience.

Contact
Cyrille Vaillend

Postdoctoral researcher (M/F)

12 months
The “Computational Neuroscience” group of Paris-Saclay Neuroscience Institute (NeuroPSI), and the European Institute for Theoretical Neuroscience (EITN), recruit a postdoctoral researcher for the computer modeling of neural networks implicated in cerebral responses and sensory perception. This work will contribute to the European-funded “Human Brain Project”.

General information
• Reference : UMR9197-ALIGIN-023
• Workplace : SACLAY
• Date of publication : Friday, June 3, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 1 September 2022
• Proportion of work : Full time
• Remuneration : between 2 743 and 4 339€ before tax, according to the CNRS regulation
• Desired level of education : 5-year university degree
• Experience required : Indifferent

Missions
The “Computational Neuroscience” group of Paris-Saclay Neuroscience Institute (NeuroPSI), and the European Institute for Theoretical Neuroscience (EITN), recruit a postdoctoral researcher for the computer modeling of neural networks implicated in cerebral responses and sensory perception. This work will contribute to the European-funded “Human Brain Project”.

Activities
• Computer based modeling and analysis
• Adaptation of existing neural models to include responses to stimuli and perception
• Participate to the scientific animation of the group and the EITN

Skills
• Excellent knowledge of neuroscience and computational neuroscience
• Knowledge of biophysics
• Pyhon programming
• Excellent knowledge of English language
• Being autonomous but also work in a team.

Work Context
The “Computational Neuroscience” group is composed of 7 researchers and 2 engineers, and is part of the “Integrative and Computational Neuroscience” (ICN) department of the Paris-Saclay Neuroscience Institute (NeuroPSI). These groups also run the European Institute of Theoretical Neuroscience (EITN). The research team is inter-disciplinary, at the interface between physics, computer science and neurosciences, with a strong implication in European projects.

Contact
Alain Destexhe

Postdoctoral fellow in Neuroscience: neuronal control of movement

12 months
We are looking for a talented and motivated postdoctoral fellow to lead a project on the organization of motor descending pathways of the brainstem, in health and in mouse models of spinal cord injuries.

General information
• Reference : UMR9197-ODILEC2-107
• Workplace : SACLAY
• Date of publication : Thursday, June 2, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 1 September 2022
• Proportion of work : Full time
• Remuneration : between 2743 and 3161 before tax, according to the CNRS regulation
• Desired level of education : PhD
• Experience required : 1 to 4 years

Missions
We are looking for a talented and motivated postdoctoral fellow to lead a project on the organization of motor descending pathways of the brainstem, in health and in mouse models of spinal cord injuries.

Activities
The main missions include:
• Injections of retrograde/anterograde viral tracers in the nervous system of mice
• histology and microscopy
• analysis of behavior and motor skills
• presentation and dissemination of data in the form of seminars and articles

Secondary missions include:
• co-supervision of trainees (Master’s students, PhD students)

Skills
Conceptual:
• Doctoral degree in Neuroscience.
• Knowledge in the neural control of movements and the organization of the brainstem and the spinal cord.
• Interest in therapeutic approaches in spinal cord injury models
Experimental:
• work on genetically modified mice lines
• stereotactic surgery
• circuit neuroscience: conventional and viral tracing tools
• kinematic analysis
• histology, fluorescence microscopy
• IT tools (office, data processing, and ideally Matlab, R, or Python programming)
General:
• curiosity, critical thinking
• teamwork, mutual aid, and solidarity
• fluent French or English

Work Context
The research will take place at the Paris-Saclay Institute of Neuroscience. The host team, “neural circuits and motor control” (julien-bouvier-team), is made up of neurobiologists who share an interest in the neuronal circuits of movements. The candidate will have access to state-of-the-art equipment for the manipulation of neuronal types in mice, behavioral analysis, and microscopy.
The researcher will be placed under the responsibility of the team leader.

Constraints and risks
Risks related to animal experimentation, chemicals, and biological agents.

Contact
Julien Bouvier

Postdoctoral researcher (M/F)

14 months
The post-doctoral researcher will contribute to the NewBornNeurons project, in synergy with other projects from team NII. He/she will first focus oh phenotyping the new transgenic zebrafish lines required for the project, then will optimize tamoxifen treatments and develop new injury methods to study neuronal regeneration.

General information
• Reference : UMR9197-ODILEC2-105
• Workplace : SACLAY
• Date of publication : Tuesday, May 24, 2022
• Type of Contract : FTC Scientist
• Contract Period : 14 months
• Expected date of employment : 1 July 2022
• Proportion of work : Full time
• Remuneration : gross monthly salary between 3800 € and 4056 € depending on experience (according to the CNRS salary scale)
• Desired level of education : 5-year university degree
• Experience required : Indifferent

Missions
The post-doctoral researcher will contribute to the NewBornNeurons project, in synergy with other projects from team NII. He/she will first focus oh phenotyping the new transgenic zebrafish lines required for the project, then will optimize tamoxifen treatments and develop new injury methods to study neuronal regeneration.

Activities
• Management of a scientific project
• Master student supervision;
• Contribution to redaction of animal experiment projects and scientific articles;
• Zebrafish lines management, phenotyping using fluorescence microscopy of live animals or fixed samples after immune-histochemistry;
• Pharmacological treatments;
• Setting up controlled brain injuries;
• Analysis of cellular mechanisms of brain regeneration

Skills
• Autonomy and team work ;
• good communication in English;
• Writing scientific documents;
• Animal experimentation habilitation;
• Advanced knowledge in neurobiology and development biology, preferably in the zebrafish model ;
• Genetics ;
• Proficient in intravital microscopy, phenotyping methods and image analysis

Work Context
The Paris-Saclay Neuroscience Institute (Neuro-PSI) is a joint structure between CNRS and Paris-Saclay University, recently installed in a brand new building on the Saclay campus. Its 21 research teams tackle the nervous system under various angles and scales, thanks notably to various animal models.
Team-Infection and Immunity (NII), also affiliated to Institut Pasteur, is studying the impact of neuroinflammation on brain development and regeneration, notably but not only in the context of viral encephalitis.
It relies on the zebrafish as an animal model. Currently, the team gathers 3 researchers, 1 engineer and 2 students.
This project is funded by ANR (NewBornNeurons grant) in the frame of a collaboration with the team of German Sumbre at ENS, paris. The post-doctoral researcher will be co-supervised by Dr Jean-Stéphane Joly (DR INRAE) and by the team head Dr Jean-Pierre Levraud (DR Institut Pasteur). He/she will also interact with all other members of the NII team, with members of Dr Sumbre’s laboratory, and will tightly interact with the neighbor TEFOR Paris-Saclay platform for production and phenotyping of zebrafish lines, as well as other technical services of Neuro-PSI.

Contact
Jean-Pierre Levraud

Postdoctoral researcher (M/F)

1 year
As part of a collaborative research project on the effects of environmental pollution on the mouse brain, we are particularly studying in our team the behavioral and imaging aspects. The researcher will participate in the analyzes of behavioral data already obtained and will conduct new experiments (social behavior, decision task, etc.) in mice previously exposed to polluted atmospheres.

General information
• Reference : UMR9197-ODILEC2-103
• Workplace : SACLAY
• Date of publication : Monday, May 9, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 1 September 2022
• Proportion of work : Full time
• Remuneration : Gross monthly salary between €2700 and €3800 depending on experience (according to the CNRS salary scale)
• Desired level of education : PhD
• Experience required : Indifferent

Missions
As part of a collaborative research project on the effects of environmental pollution on the mouse brain, we are particularly studying in our team the behavioral and imaging aspects.
The researcher will participate in the analyzes of behavioral data already obtained and will conduct new experiments (social behavior, decision task, etc.) in mice previously exposed to polluted atmospheres. The recruited candidate will participate in the molecular and histological analyzes carried out on the brains. He/she will participate in functional brain imaging experiments in mice and will take charge of the analyzes of these data in which he/she will be trained if necessary.

Activities
• video and audio data analysis of social behaviors
• support for the development and conduction of gambling experience in automated devices
• histological and molecular analyzes
• conduct of functional brain imaging experiments (fMRI) and data analysis

Skills
• Knowledge of animal (rodent) behavior and data analysis in this area, including statistical analysis, required.
• Prior expertise in molecular and histological analyzes is required.
• Knowledge of MRI data analysis is not necessary, but an interest in being trained in it is essential.
• Programming basics (python, matlab) are a plus.
• Fluency in French and English (oral and written) required

• Teamwork, written communication, organization, independence

Work Context
The building of the Paris-Saclay Institute of Neurosciences, NeuroPSI is located on the CEA site in Saclay, next to the NeuroSpin brain imaging institute. Behavioral experiments will take place at NeuroPSI and imaging experiments at NeuroSpin.
Neuro-PSI includes 21 research teams, platforms and technical services allowing the study of brain function in several animal models at all levels. The postdoctoral researcher will work in the team led by Sylvie Granon, Neurobiology of decision-making (group-leader-sylvie-granon). This team includes 2 university teacher-researchers, 2 CNRS researchers, an emeritus CNRS researcher and 3 PhD students (3rd, 2nd and 1st year).
Access to the CEA site is served by a bus service from the RER the counter and Massy. Nevertheless, the transport time from Paris requires several changes and is around 1h20 minutes, around 40 minutes by car depending on traffic.

Additional Information
Possible contract extension.

Contact
Sylvie Granon

Postdoctoral researcher (M/F)

1 year renewable
The candidate will contribute to a project on investigating neural circuit mechanisms underlying diverse computations like decision and learning and their modulation by the context using a multidisciplinary approach.

General information
• Reference : UMR9197-ODILEC2-104
• Workplace : SACLAY
• Date of publication : Thursday, May 19, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 10 July 2022
• Proportion of work : Full time
• Remuneration : gross monthly salary between €2728 and €4056 depending on experience (according to the CNRS salary scale)
• Desired level of education : PhD
• Experience required : Indifferent

Missions
The candidate will contribute to a project on investigating neural circuit mechanisms underlying diverse computations like decision and learning and their modulation by the context using a multidisciplinary approach that combines neural manipulation during behavior, electron microscopy (EM) reconstruction of neuronal connectivity at a synaptic level and recording of neuronal activity in the Drosophila larva with Calcium-imaging.

Activities
• Immunohistochemistry in Drosophila nervous system
• Drosophila genetics
• Behavioral experiments (automated tracking and analysis)
• confocal and 2-photon microscopy (Calcium-imaging)
• electron microscopy reconstruction of synaptic connections.
• connectivity analysis

Skills
Scientific skills
• General knowledge in Drosophila neurobiology
• Experience in Calcium-imaging using bi-photon microscopy
• Basics in programming (Matlab, Python)
• English

Other skills
• team work
• organization skills
• Independence

Work Context
We are seeking candidatures of highly motivated individuals, preferably with background in neuroscience. PhD in neuroscience, biology or related fields is required. Experience in Calcium- imaging and/or connectomics will be appreciated.
The candidate will work in the team Neural Circuits and Behavior headed by Tihana Jovanic in the Molecules & Circuits department at the newly founded Neuroscience Paris Saclay Institute (Neuro-PSI) in Saclay (20 km south of Paris) dedicated to fundamental research in Neuroscience. NeuroPSI has state-of the art core facilities and the Saclay campus provides a highly interdisciplinary and collaborative environment mixing university and engineering schools, with excellent laboratories in fundamental and applied science. The project will give opportunities for both national and international collaborations

Additional Information
Possible contract extension.

Contact
Tihana Jovanic

Post-doc position in Neural Circuits and Behavior in Drosophila

1 year renewable up to 3 years
A postdoc position is available to join the Neural circuits and Behavior team headed by Tihana Jovanic in the Cognition and Neural Network Department at Paris Saclay Institute of Neuroscience (NeuroPSI). The team uses Drosophila larva as a model system to map neural circuits using a multidisciplinary approach that combines neural manipulation during behavior, electron microscopy (EM) reconstruction of neuronal connectivity at a synaptic level and recording of neuronal activity using Calcium imaging in the Drosophila larva with the goal of understanding computational principles underlying complex behaviours and their modulation by the context and internal state.
More details about the team can be found here: /en/departments/cnn/group-leader-tihana-jovanic

We are seeking applications of highly motivated individuals, preferably with background in neuroscience. PhD in neuroscience, biology or related fields is required. Experience in Calcium-imaging and/or programming will be appreciated. The work will include connectivity analyses based on EM reconstruction as well as optogenetics and Calcium-imaging and there will be opportunities for national and international collaborations, and specifically within consortium of teams in US, Germany and France funded by the Collaborative Research in Computational Neuroscience program.

Anticipated start date is spring 2022, Paris Saclay Institute of Neuroscience (NeuroPSI) is located in Saclay (20 km south of Paris) and is dedicated to fundamental research in Neuroscience. NeuroPSI has state-of the art core facilities and the Saclay campus provides a highly interdisciplinary and collaborative environment mixing university and engineering schools, with excellent laboratories in fundamental and applied science.

Anticipated start date is mid-2022
For more details about the project and position please contact Tihana Jovanic
tihana.jovanic@cnrs.fr

Candidates should send a CV, a motivation letter and contacts of two references.
tihana.jovanic@cnrs.fr

Review of applications will begin immediately and will continue until the position is filled.

Postdoctoral Researcher in the study of neuroglial interactions

2 years

We are searching for a talented postdoctoral fellow interested in the study of neuroglial interactions in Glenn Dallérac’s lab (departments/cnn/group-leader-glenn-dallerac) at the Paris-Saclay Institute of Neuroscience.
Brain information processing is classically perceived as a neuronal task. However, a major breakthrough in Neuroscience has been the realization that the dogmatic view of glial cells as being merely fostering and buffering elements of the nervous system is inaccurate. Astroglial cells are in fact dynamic signaling elements of the brain. They are able to sense neuronal inputs and modulate adjacent neuronal elements through various mechanisms including uptake and release of neuroactive factors, contact-mediated signaling or plastic physical coverage of synapses.

The selected candidate will explore the implication of neuroglial interactions in the monoaminergic modulations of neuronal activities, information processing and cognitive functions. The position implies in vivo electrophysiological recordings during behavior, as well as imaging using head-fixed 2-photon microscopy. Experience in in vivo electrophysiological or imaging data processing is required. Animal surgery, animal handling and programming skills are beneficial.

Application should include a cover letter exposing your motivations, CV, list of publications, and names of 2 references. Please send to: glenn.dallerac@universite-paris-saclay.fr

Contact: Glenn Dallérac

Post-doctoral position « Eye development in Astyanax mexicanus »

12 months

The hired individual (postdoctoral researcher) will contribute to research projects supported by an ANR grant entitled « Maternal Control of Phenotypic Evolution ».

General information
• Reference : UMR9197-ODILEC2-106
• Workplace : SACLAY
• Date of publication : Monday, May 30, 2022
• Type of Contract : FTC Scientist
• Contract Period : 12 months
• Expected date of employment : 1 October 2022
• Proportion of work : Full time
• Remuneration : gross monthly salary between €2700 and €3800 depending on experience (according to the CNRS salary scale)
• Desired level of education : 5-year university degree
• Experience required : Indifferent

Missions
The hired individual (postdoctoral researcher) will contribute to research projects supported by an ANR grant entitled « Maternal Control of Phenotypic Evolution ».

Activities
Research: molecular and morphogenetic mechanisms underlying eye malformations in the blind Mexican cavefish.
• Bioinformatics analyses
• Embryology and gain/loss of function experiments
• Reporting, writing, presenting results

Skills
Theoretical:
• development biology,
• neurobiology,
• evo-devo.

Technical:
• Ggenome edition, transgenesis in fish models;
• Imaging; embryology, scRNA-Seq.

Motivation, rigor, inventiveness, precision.
Ability to work in a team and in autonomy.

Work Context
The hired individual will work at the Paris-Saclay Institute of Neuroscience (Neuro-PSI), which currently gathers about 25 research teams (~250 people). She/He will join the team “Development and evolution of the forebrain” (2 CNRS researchers, 1 associate professor, 1 engineer, 1 technician, 1 postdoc, 2 PhD students), and will work under the supervision of the team leader (S. Rétaux).

Contact
Sylvie Rétaux

Post-doctoral position « Behavioral evolution in Astyanax mexicanus » H/F

2 years

The hired individual (postdoctoral researcher) will contribute to research projects supported by an Equipe FRM grant entitled « Neurogenetics of the blind cavefish, Astyanax mexicanus ».

General information
• Reference : UMR9197-ODILEC2-100
• Workplace : SACLAY
• Date of publication : Thursday, April 7, 2022
• Type of Contract : FTC Scientist
• Contract Period : 24 months
• Expected date of employment : 1 October 2022
• Proportion of work : Full time
• Remuneration : -gross monthly salary between 2700 € and 3800 € depending on experience (according to the CNRS salary scale)
• Desired level of education : PhD
• Experience required : Indifferent

Missions
The hired individual (postdoctoral researcher) will contribute to research projects supported by an Equipe FRM grant entitled « Neurogenetics of the blind cavefish, Astyanax mexicanus ».

Activities
Research: genetic and neuronal mechanisms underlying the evolution of behaviors in the blind Mexican cavefish.

Skills
• Theoretical: neurobiology, ethology, evo-devo.
• Technical: behavioral analyses, neuro-anatomical analyses, genome edition, transgenesis in fish models; imaging; embryology.
• Motivation, rigor, inventiveness, precision.
• Ability to work in a team and in autonomy.

Work Context
The hired individual will work at the Paris-Saclay Institute of Neuroscience (Neuro-PSI), which currently gathers about 25 research teams (~300 people). She/He will join the team “Development and evolution of the forebrain” (2 CNRS researchers, 1 associate professor, 1 engineer, 1 technician, 1 postdoc, 2 PhD students), and will work under the supervision of the team leader (S. Rétaux).

Contact
Sylvie Rétaux

Postdoc in Neurosciences – in vivo electrophysiology and imaging

24 months

We are searching for a talented postdoctoral fellow interested in the study of neuroglial interactions in Glenn Dallérac’s lab at the Paris-Saclay Institute of Neuroscience.

General information
• Reference : UMR9197-GLEDAL-003
• Workplace : SACLAY
• Date of publication : Thursday, April 7, 2022
• Type of Contract : FTC Scientist
• Contract Period : 24 months
• Expected date of employment : 1 June 2022
• Proportion of work : Full time
• Remuneration : ~3000€ gross salary
• Desired level of education : PhD
• Experience required : Indifferent

Missions
We are searching for a talented postdoctoral fellow interested in the study of neuroglial interactions in Glenn Dallérac’s lab at the Paris-Saclay Institute of Neuroscience.

Activities
Brain information processing is classically perceived as a neuronal task. However, a major breakthrough in Neuroscience has been the realization that the dogmatic view of glial cells as being merely fostering and buffering elements of the nervous system is inaccurate. Astroglial cells are in fact dynamic signaling elements of the brain. They are able to sense neuronal inputs and modulate adjacent neuronal elements through various mechanisms including uptake and release of neuroactive factors, contact-mediated signaling or plastic physical coverage of synapses.

The selected candidate will explore the implication of neuroglial interactions in the monoaminergic modulations of neuronal activities, information processing and cognitive functions.

Skills
The position implies in vivo electrophysiological recordings during behavior, as well as imaging using head-fixed 2-photon microscopy. Experience in in vivo electrophysiological or imaging data processing is required. Animal surgery, animal handling and programming skills are beneficial.

Work Context
The work will be performed in the brand new building of the Paris-Saclay Institute of Neurosciences.

Additional Information
Application should include a cover letter exposing your motivations, CV, list of publications, and names of 2 references.

Contact
Glenn Dallerac

Post-doc position in birdsong neurophysiology

24 months

The goal of the position is to study the principles of vocal learning and communication in songbirds. We combine diverse experimental and theoretical approaches to gain new insights into higher cognitive functions associated with complex vocal behaviors such as song learning.

General information
• Reference : UMR9197-NICGIR-001
• Workplace : SACLAY
• Date of publication : Tuesday, October 5, 2021
• Type of Contract : FTC Scientist
• Contract Period : 24 months
• Expected date of employment : 1 November 2021
• Proportion of work : Full time
• Remuneration : Month salary (with charges) between 2743 € and 3896 € according to level of experience (salary based on CNRS policies)
• Desired level of education : PhD
• Experience required : 1 to 4 years

Missions
The goal of the position is to study the principles of vocal learning and communication in songbirds. We combine diverse experimental and theoretical approaches to gain new insights into higher cognitive functions associated with complex vocal behaviors such as song learning.

Activities
Data collection, data analysis, communication (publication, participation to workshop and international congress), development.

Skills
• PhD in neuroscience or engineering.
• Strong interest in neuroscience.
• Expertise in signal processing and machine learning.
• Able to collaborate with biologists and engineers in a nurturing environment.
• Independent and able to be part of a team

Work Context
We are interested in decoding neural activity associated with song production and song learning in songbirds. In collaboration with the Institute of Neuroinformatics of the ETH Zürich and the University of Zurich (Richard Hahnloser’s lab), we have recently developed a system for simultaneously recording from many neurons in freely behaving animals. Our lightweight 384-channels recording device incorporates the Neuropixel probes. The project is to put this technology to use to study the mysteries of neural population codes and to advance our understanding of how individual neurons contribute to forming a representation of motor plans and of sensory feedback.
The open position is funded by the “Agence Nationale de la Recherche” (ANR) for a Post-Doc at the interface of engineering and neuroscience and will take place at the Neuroscience Paris Saclay Institute.

Contact
Nicolas Giret

Thesis

Mouse models of behavioral disorders associated with Duchenne Muscular Dystrophy

3 years

To understand the neurogenetic and neurobiological bases of behavioral and cognitive deficits associated with Duchenne Muscular Dystrophy, using mouse models, and to test new therapeutic approaches to compensate these deficits.

General information
• Reference : UMR9197-ODILEC2-093
• Workplace : SACLAY
• Date of publication : Friday, October 8, 2021
• Scientific Responsible name : VAILLEND Cyrille
• Type of Contract : PhD Student contract / Thesis offer
• Contract Period : 36 months
• Start date of the thesis : 1 January 2022
• Proportion of work : Full time
• Remuneration : 2 135,00 € gross monthly

Description of the thesis topic
Mouse models of behavioral disorders associated with Duchenne Muscular Dystrophy. To understand the neurogenetic and neurobiological bases of behavioral and cognitive deficits associated with Duchenne Muscular Dystrophy, using mouse models, and to test new therapeutic approaches to compensate these deficits.

Work Context
The thesis work will be carried out in the new Paris-Saclay Neuroscience Institute to Saclay, in collaboration with clinicians and several foreign teams.

Contact
Cyrille VAILLEND

Role of neuroglial interactions in the cerebellar control of motor and cognitive functions

3 years

The cerebellum in a brain structure well-known for its role in the control of motor function. Yet, a growing body of clinical as well as experimental data point to its implication in cognitive functions. The cerbellem display a peculiar anatomical organisation, subdivided in distinct lobules that are connected, via the deep nuclei, to numerous motor and non-motor brain regions. Intriguingly, the cerebellum displays a unique form of highly specialized astroglia, the Bergmann glial cells (BGCs), closely interacting with Purkinje cells (PCs), the only neuronal output of the cerebellar cortex. The proposed thesis project aims at investigating the contribution of BGCs on the monoaminergic control of PC activities, and to which extent this participate in motor and cognitive processes.

General information
• Reference : UMR9197-GLEDAL-001
• Workplace : SACLAY
• Date of publication : Monday, October 4, 2021
• Scientific Responsible name : Glenn Dallérac
• Type of Contract : PhD Student contract / Thesis offer
• Contract Period : 36 months
• Start date of the thesis : 1 December 2021
• Proportion of work : Full time
• Remuneration : 2 135,00 € gross monthly

Description of the thesis topic
The cerebellum in a brain structure well-known for its role in the control of motor function. Yet, a growing body of clinical as well as experimental data point to its implication in cognitive functions. The cerbellem display a peculiar anatomical organisation, subdivided in distinct lobules that are connected, via the deep nuclei, to numerous motor and non-motor brain regions such as the prefrontal cortex, the ventral tegmental area and the hippocampus, thus providing anatomical basis for its influence on motor as well as cognitive aspects of behavior. Beyond the lobular organization, within each lobules clusters of cerebellar cortex neurons (Purkinje Cells, PC) are synchroneously activated such that functional microzones can be defined. Thus, the cerebellar contribution to motor and cognitive functions would occur through adaptation to multiple contingencies through selective activations of specific microzones.

Interestingly, modeling studies suggesting a modular organization of the cerebellum through these microzones propose that the signal delineating these cerebellar microzones has been proposed to lie in the neuromodulatory aminergic inputs of the cerebellum. Yet, monoaminergic projections do not form synaptic specialization and operate through diffuse volume transmission, unlikely to suffice in defining specific microzones taking part in cognitive loops. Intriguingly, the cerebellum displays a unique form of highly specialized astroglia, the Bergmann glial cells (BGCs), closely interacting with Purkinje cells (PCs), the only neuronal output of the cerebellar cortex. They represent a major cell type of the cerebellar cortex, largely PCs and are well known for assisting neuronal activities by ensuring water, ions and glutamate homeostasis as well as metabolic support. Besides their role in these ‘housekeeping’ functions, BGCs have been found to control synaptic transmission, notably though modulation of synapse coverage. Our recent data show that the dense and finely meshed network provided by BGCs express the monoamine transporter VMAT2 and the monoamine (dopamine and noradrenaline) transporter DAT, an atypical feature in astroglial cells.

We therefore hypothesize that through this unique property, BGCs modulate monoaminergic homeostasis in the cerebellar cortex allowing accurate delineation of microzones and control of motor and cognitive functions. The proposed thesis project thus aims at investigating the contribution of BGCs on the monoaminergic control of PC activities, and to which extent this participate in motor and cognitive processes.

Work Context
This research will be perfomed in the team of Glenn Dallérac at the Paris-Saclay Institute for Neurosciences. The PhD student will be supervised by Micaela Galante and Glenn Dallérac.

Contact
Glenn DALLERAC

Embodiment of a prosthesis controlled through a brain-machine interface in a mouse model (H/F)

3 years

Invasive brain-machine interfaces (BMIs) offer patients with severe motor deficits hope of regaining a degree of autonomy by controlling a robotic arm via neuronal activity recorded in their motor cortex. in our lab, we have built on the features of the mouse model to establish a bidirectional (sensory-motor) interface and thus begin to address the challenge of including artificial tactile feedback in prostheses.

General information
• Reference : UMR9197-LUCEST-004
• Workplace : GIF SUR YVETTE
• Date of publication : Tuesday, August 3, 2021
• Scientific Responsible name : Luc Estebanez
• Type of Contract : PhD Student contract / Thesis offer
• Contract Period : 36 months
• Start date of the thesis : 1 October 2021
• Proportion of work : Full time
• Remuneration : 2 135,00 € gross monthly

Description of the thesis topic
Invasive brain-machine interfaces (BMIs) offer patients with severe motor deficits hope of regaining a degree of autonomy by controlling a robotic arm via neuronal activity recorded in their motor cortex. Still in a very experimental phase in humans, research on BMIs is conducted mainly in primates. The lack of preclinical research in rodents has greatly slowed the exploration of innovative interfacing strategies. For example, until now, invasive BMIs in monkeys and humans are actuated, but the lack of sensory feedback from the prosthesis to the user strongly limits their practical use.

Instead, in our lab, we have built on the features of the mouse model to establish a bidirectional (sensory-motor) interface and thus begin to address the challenge of including artificial tactile feedback in prostheses (Abbasi et al. 2018, Goueytes et al. 2019, Abbasi et al. 2019). Our goal during this project is to develop from our BMI a true brain-prosthesis interface in mice. To this end, we are currently developing a miniature biomimetic robotic arm at a scale commensurable with a mouse.

This development is unparalleled in the BMI community and is made possible by the use of 3D printing of numerous precision parts, in collaboration with Prof. Antoine Chaillet and Dr. Maria Makarov at CentraleSupélec. In will be actively disseminated to the research community, on the basis of the open hardware movement.

The current implementation of this robotic arm with several degrees of freedom will allow us to test our hypotheses concerning the control of a physical prosthesis. To do so, the arm will be attached to a support placed next to a mouse trained to remain motionless to perform a control task of the robotic arm. Thus, in parallel to the finalization of this prosthesis, the PhD student will be able to exploit it to explore two strong themes of the team:
• (1) the integration of visual and tactile information for the control of the artificial paw.
• (2) the impact of motor control of the physical prosthesis on its appropriation.

Work Context
The “Sensory-Motor Processing and Plasticity” team is located in the Paris-Saclay Neuroscience Institute (NeuroPSI), made of some 300 neuroscience researchers, in the heart of the Saclay campus. The team of 10 people (4 permanent researchers) explores the themes of sensory-motor integration through the development and study of brain-machine interfaces and in-vivo preparations.

Contact
Luc Estebanez

Mission

No current announcement.

Other fixed-term contracts