Patricia Kreis

Patricia Kreis

Institute of Molecular Biology and Biochemistry, Charité – Universitätsmedizin Berlin, Germany

Oxidative stress dependent regulation of Ataxia Telengiectasia Mutated (ATM) kinase at the central nervous system synapse.

To ensure survival in an ever-changing, complex world, animal behavior needs to be flexible and adaptive. Nervous systems have evolved to enable behavioral responses to a wide variety of sensory stimuli, but the adequate response to a given stimulus is highly context-dependent, and behavioral or internal states accordingly affect sensorimotor processing. For example, locomotion modulates responses of visual neurons, and hunger increases food-searching behavior and shifts taste preferences. Despite their ubiquitous importance, the neural mechanisms enabling context-dependent sensorimotor flexibility are not well understood. My lab aims to shed light on these mechanisms by leveraging the power of neurogenetics, electron microscopy-based circuit reconstruction, and in-vivo patch-clamp recordings in behaving Drosophila. In this talk, I will first focus on the key role descending neurons play in selecting contextually appropriate behaviors. Second, I will discuss our efforts to develop a better understanding of the complex arsenal of modulatory neurons in the brain, and their role in conferring flexibility to sensorimotor circuits.

Invited by Jean-Vianney Barnier

The event is finished.

Date

Oct 28 2022
Expired!

Time

11h00
Category

Organizer

BARNIER Jean-Vianney

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