• Reference : UMR9197-ODILEC2-078
• Workplace : ORSAY
• Date of publication : Tuesday, November 17, 2020
• Type of Contract : FTC Scientist
• Contract Period : 6 months
• Expected date of employment : 1 January 2021
• Proportion of work : Full time
• Remuneration : gross monthly salary approximately € 2,729
• Desired level of education : 5-year university degree
• Experience required : 1 to 4 years
The Duchenne muscular dystrophy (DMD) syndrome is associated with variable degrees of cognitive impairments that may include intellectual disability and neuropsychiatric disorders. The main objective will be to better understand how distinct mutations within the same gene (DMD gene) responsible for this neuromuscular disease influence the severity and/or nature of the comorbid cognitive and behavioral disturbances. The study shall lead to the identification of phenotypes that can serve as a marker of the efficacy of treatments for preclinical studies.
The applicant will organize and undertake in-depth comparative studies of several mouse models holding distinct mutations in the DMD gene to address a range of cognitive and executive functions in a variety of behavioral paradigms. He/she will also perform statistical analyses, generate and archive results reports, and contribute to dissemination of the produced knowledge through scientific written and oral communications in French and/or English.
The applicants should have a recent PhD in neuroscience and experience in mouse behavior and biostatistics; hands-on experience in intra-cranial surgeries will be a plus. The applicant is expected to have good verbal/written communication skills in English and a critical approach to scientific literature.
The applicant will independently carry out his/her project under the direction of C Vaillend, in interaction with other researchers, students and technicians, in a collaborative environment including molecular and clinical studies, at the international level as part of a project funded by the European Union (European Union’s Horizon 2020 research and innovation program).
The contract may be extended.
Phone : +33(0) 1 69 15 49 85
Functional studies of candidate pediatric cancers driver’s genes in a rare pediatric cancer.
The student will develop behavioral paradigms and new analyses based on the existing set ups in the lab (automated video-tracking, automated behavioral detection, quantitative behavioral analysis), by using both his/her ideas and existing protocols in the literature. This internship is also an opportunity to discover the Drosophila model, learn its advantages and other techniques used in the lab from Drosophula genetics to connectomics and functional imaging. The candidate will work in the team Neural Circuits and Behavior headed by Tihana Jovanic in Saclay (20 km south of Paris). NeuroPSI has state-of the art core facilities and the Saclay campus provides a highly interdisciplinary and collaborative environment mixing university and engineering schools, with excellent laboratories in fundamental and applied science. There will also be opprotunities for collaboration with the Janelia Research Campus (USA) and Institut Pasteur (Paris, France).
M1 and M2 internships available. The team of Neurogenetics of Drosophila, headed by Daniel Vasiliauskas, has a number of Masters (M1 and M2) projects available, two of which are highlighted here.
The hired individual (postdoctoral researcher) will contribute to research projects supported by an Equipe FRM grant, on morphogenetic mechanisms underlying eye malformations in the blind Mexican cavefish.
The « Computational Neuroscience » group of NeuroPSI Institute, and the European Institute for Theoretical Neuroscience (EITN), recruit a postdoctoral researcher for the computer modeling of neural networks implicated in decision making, in collaboration with Ruben Moreno-Bote (Barcelona).