Muriel Perron Team

Stem Cells and Neurogenesis in the Retina (SCaNR)
Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)

In brief

Our SCaNR research group is associated with the private laboratory of Retina France association, the CERTO (Centre d’Etudes et de Recherches Thérapeutiques en Ophtalmologie), with whom we are developing our research projects in collaboration. Our long-term goal is to provide foundations for the development of innovative therapeutic approaches in patients afflicted with degenerative retinal diseases, such as Retinitis Pigmentosa (RP) or Aged Macular Degeneration (AMD).

Our research

One therapeutic strategy for retinal degenerative diseases is to revitalize the naturally limited regenerative capacity of the mammalian retina. In fish and amphibians, different populations of stem cells contribute efficiently to the regeneration of the retina following injury.
These animals thus offer powerful model systems to dissect signaling pathways underlying regeneration and provide essential information to stimulate the proliferation and neurogenic potential of dormant retinal stem cells in mammals. In this context, we study and compare in both Xenopus and mouse, two models with very different regenerative capacities, the mechanisms underlying the maintenance, recruitment and activity of adult retinal stem cells in neural tissue homeostasis and regeneration.

We are also developing other axis of research dedicated to gene therapy and neuroprotection.

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Selected Publications

> Masson C., García-García D., Bitard J., Grellier É-K., Roger J.E., Perron M. (2020). Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy. bioRxiv.02.18.953943 - Cell Death Dis 11, 631.

> García-García D., Locker M., Perron M. (2020). Update on Müller glia regenerative potential for retinal repair. Curr Opin Genet Dev Jun 30;64:52-59.

> Hamon, A.*,García-García, D.*, Ail, D.*, Bitard, J., Chesneau A., Dalkara, D., Locker, M., Roger, J.§ and Perron, M.§ Linking YAP to Müller glia quiescence exit in the degenerative retina. Cell Reports, 2019, 7(6):1712-1725.e6., (doi: 10.1016/j.celrep.2019.04.045) (hal-02136721v1)

> Langhe R.*, Chesneau A.*, Colozza G., Hidalgo M., Locker M. and Perron M. Müller glial cell reactivation in Xenopus models of retinal degeneration. Glia, 2017, 65(8):1333-1349, (doi: 10.1002/glia.23165) (hal-01661186v1)

> Cabochette P*, Vega-Lopez G*, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O§, Perron M§. YAP controls retinal stem cell DNA replication timing and genomic stability. eLife, 2015, 4:e08488, (doi: 10.7554/eLife.08488) (hal-01240857v1)

* Co-first authors
§ Co-corresponding authors

• Variant
• Fondation Valentin Haüy
• Equipe FRM
• Université Paris-Saclay
Team members