Muriel Perron Team

Stem Cells and Neurogenesis in the Retina (SCaNR)
Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)

In brief

Our SCaNR research group is associated with the private laboratory of Retina France association, the CERTO (Centre d’Etudes et de Recherches Thérapeutiques en Ophtalmologie), with whom we are developing our research projects in collaboration. Our long-term goal is to provide foundations for the development of innovative therapeutic approaches in patients afflicted with degenerative retinal diseases, such as Retinitis Pigmentosa (RP) or Aged Macular Degeneration (AMD).

Our research

One of the intended strategy is to revitalize the naturally limited regenerative capacity of the mammalian retina. In fish and amphibians , different populations of stem cells contribute efficiently to the regeneration of the retina following injury. These animals thus offers powerful model system to dissect the signaling pathways underlying regeneration and provide essential information to stimulate the proliferation and neurogenic potential of dormant retinal stem cells in mammals. In this context, we study and compare in both Xenopus and mouse, two models with very different regenerative capacities, the mechanisms underlying the maintenance, recruitment and activity of adult retinal stem cells in neural tissue homeostasis and regeneration.
Neuroprotection represents another promising avenue for potential therapeutic approaches to treat retinal degenerative diseases. We are thus developing another axis of research dedicated to the study of the molecular mechanisms and signalling pathways underlying photoreceptor survival.

Our team is affiliated to the GDR « Stem Cells in vivo ».

Selected Publications

> Hamon, A.*,García-García, D.*, Ail, D.*, Bitard, J., Chesneau A., Dalkara, D., Locker, M., Roger, J.§ and Perron, M.§ Linking YAP to Müller glia quiescence exit in the degenerative retina. Cell Reports, 2019, 7(6):1712-1725.e6., (doi: 10.1016/j.celrep.2019.04.045) (hal-02136721v1)

> Langhe R.*, Chesneau A.*, Colozza G., Hidalgo M., Locker M. and Perron M. Müller glial cell reactivation in Xenopus models of retinal degeneration. Glia, 2017, 65(8):1333-1349, (doi: 10.1002/glia.23165) (hal-01661186v1)

> Cabochette P*, Vega-Lopez G*, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O§, Perron M§. YAP controls retinal stem cell DNA replication timing and genomic stability. eLife, 2015, 4:e08488, (doi: 10.7554/eLife.08488) (hal-01240857v1)

* Co-first authors
§ Co-corresponding authors

Team members

Members

Collaborations :

 

Eric Bellefroid, Université de Bruxelles, Belgium
Kris Vleminckx, Ghent University, Belgium
Tomas Pieler, Kris Henningfeld, Gottingen University, Germany
Tomas Holleman, Martin-Luther-Universität Halle-Wittenberg, Germany
Nicolas Pollet, Université d’Evry, France
Christelle Monville, I-Stem, France
Florian Sennlaub, Olivier Goureau, Deniz Dalkara, Institut de la Vision, France
Kathrin Marheineke, I2BC Gif-sur-Yvette, France
Anand Swaroop, National Eye Institute (Bethesda,Etats-Unis)
Xian-Jie Yang, Jules Stein Eye Institute (UCLA, Los Angeles,Etats-Unis)
Northwestern University (Chicago, Etats-Unis)
Kellogg Eye Center (University of Michigan, USA)