Cognitive & Network Neuroscience (CNN)

Head Valérie Doyère, Vice-Head Glenn Dallérac

The department of Cognitive and Network Neuroscience (CNN) seeks to decipher neural bases of behavior and cognition, as well as their alterations in neuropathologies. CNN gathers research teams that use different animal models, in the field or in the lab, to study fundamental behaviors and cognitive functions, such as communication, decision-making, learning and memory, as well as their underlying mechanisms at the cellular and network levels.

Through the study of drosophila, mice, rats, birds and marine mammals over the entire lifespan, our research projects aim at understanding
● communications between animals in different social contexts
● executive functions and their relations to brain internal states
● temporal control of behavior from seconds to circadian scales
● neurodevelopmental, neuropsychiatric, and neurodegenerative disorders and their links with aging.

A selection of representative recent publications by our Department teams

> Alejevski, F., Saint-Charles, A., Michard-Vanhée, C., Martin, B., Galant, S., Vasiliauskas, D., and Rouyer, F. (2019). The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles. Nature Comm 10, 252.
> Babski, H., Jovanic, T., Surel, C., Yoshikawa, S., Zwart, M.F., Valmier, J., Thomas, J.B., Enriquez, J., Carroll, P., and Garcès, A. (2019). A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila. Nat Commun 10, 4796.
> Faure A., Nosjean A., Pittaras E., Duchêne A., Andrieux A., Charvériat M., Granon S. (2019) Dissociated features of social cognition altered in mouse schizophrenia models: focus on social dominance and acoustic communication. Neuropharmacology, 159, 107334.
> Jovanic T, Winding M, Truman J, Cardona A, Gershow M and Zlatic M (2019) Neural substrates of Drosophila larval anemotaxis. Current Biology, 29(4):554–4.
> Petrelli F*, Dallérac G*, Pucci L*, Calì C*, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P. (2020). Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Molecular Psychiatry. 25(4):732-749.
> Dallérac G*, Graupner M*, Knippenberg J, Ruiz Martinez RCR, Ferreira Tavares T, Tallot L, El Massioui N, Verschueren A, Höhn S, Boulanger-Bertolus J, Reyes A, LeDoux JE, Schafe GE, Diaz-Mataix L & Doyère V (2017) Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. Nature Comm, 8, 13920.
> Lark A, Kitamoto T, Martin JR. (2017). Modulation of neuronal activity in the Drosophila mushroom body by DopEcR, a unique dual receptor for ecdysone and dopamine. Biochim Biophys Acta, Mol. Cell Res., 1864, 1578-1588.
> Mathevon, N., Casey, C., Reichmuth, C., & Charrier, I. (2017). Northern Elephant Seals Memorize the Rhythm and Timbre of Their Rivals’ Voices. Current Biology, 27(15), 2352-2356.
> Goyenvalle A, Griffith G, Babbs A, El Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. (2015) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med, 21(3):270-5.

Teams of the Department